Jesse B. Mez, MD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jesse Mez, MD, MS, is an Associate Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine. A neurologist with clinical training in aging and dementia and research training in biostatistics/statistical genetics and epidemiology, he is the Associate Director of the BU Alzheimer’s Disease Research Center (ADRC), Co-Director of Clinical Research of the BU Chronic Traumatic Encephalopathy (CTE) Center and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium and AD Sequencing Project Investigator. His research seeks to understand the genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. He is an internationally recognized expert on CTE, having been a lead or co-author on several of the most highly cited manuscripts and an invited lecturer in national and international venues on the topic. Ongoing research themes include 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service, and dementia-related outcomes and their interaction with genetic factors, 2) clinicopathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 150 research articles, reviews, editorials, and book chapters. He also cares for patients with AD and related dementias, including those at risk for CTE in the BU/Boston Medical Center Memory and Aging Clinic.

He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Mass General Brigham Program in Boston. This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.

Publications

  • Published 5/7/2026

    Sherva R, Bayly H, Zhang R, Harrington K, Mez J, Miller MW, Tsuang D, Wolf E, Zeng Q, Le Guen Y, Tejeda M, Gaziano JM, Panizzon MS, Hauger RL, Merritt VC, Farrer LA, Logue MW. A Genome-wide Association Study of Alzheimer's Disease and Dementia in a Large Multi-ancestry Military Cohort Identifies Many New Dementia-Associated Loci. medRxiv. 2026 May 07. PMID: 42145619.

    Read at: PubMed

  • Published 5/1/2026

    Tao Q, Han J, Ang TFA, Hou L, Liu C, Murabito JM, Lunetta KL, Mez J, Alosco ML, Stein TD, Zhang X, Au R, Farrer L, Palmisano JN, Hamburg NM, Qiu WQ. Peripheral vascular function, including endothelium-dependent measures, and dementia risk: The Framingham Heart Study. Alzheimers Dement. 2026 May; 22(5):e71396. PMID: 42050369.

    Read at: PubMed

  • Published 4/28/2026

    Kleven BC, Chien LC, Surwill D, Alosco ML, Wethe JV, Tripodis Y, Adler CH, Shenton ME, Pasternak O, Katz DI, Peskind E, Balcer LJ, Koerte IK, Mez J, Reiman EM, Cantu RC, Stern RA, Zetterberg H, Bernick C, Cummings JL. Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts. Res Sq. 2026 Apr 28. PMID: 42094043.

    Read at: PubMed

  • Published 4/16/2026

    Eissman JM, Regelson AN, Walters S, Archer DB, Durant A, Mukherjee S, Lee ML, Choi SE, Scollard P, Trittschuh EH, Mez J, Kang M, Bush WS, Kunkle BW, Naj AC, Gifford KA, Bilgel M, Kuzma AB, Cuccaro ML, Cruchaga C, Pericak-Vance MA, Farrer LA, Wang LS, Schellenberg GD, Vardarajan BN, Mayeux R, Haines JL, Jefferson AL, Kukull WA, Keene CD, Saykin AJ, Thompson PM, Martin ER, Albert MS, Johnson SC, Engelman CD, Ferrucci L, Bennett DA, Barnes LL, Schneider JA, Resnick SM, Sperling RA, Crane PK, Hohman TJ, Dumitrescu L. Sex-specific genetic drivers of memory, executive functioning and language in older adults. Brain. 2026 Apr 16. PMID: 41989867.

    Read at: PubMed

  • Published 4/14/2026

    Frank B, Gurnani A, Hurley L, Guan C, Andersen SL, Devine SA, O'Connor MK, Budson A, Liu C, Lin H, Auerbach S, Liu Y, Libon DJ, Price CC, Farrer L, Mez J, Ang A, Au R. Psychometric modeling of Boston process approach data for dementia prediction in the Framingham Heart Study. J Int Neuropsychol Soc. 2026 Apr 14; 1-12. PMID: 41975557.

    Read at: PubMed

View All 231 Publications:   View Full Profile in BUMC

Other Positions

  • Investigator
    Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Maryland School of Medicine, MD
  • Columbia University School of Public Health, MS
  • Cornell University, BS

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