Jesse B. Mez, MD
Associate Professor, Neurology
Biography
Jesse Mez, MD, MS, is an Associate Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine. A neurologist with clinical training in aging and dementia and research training in biostatistics/statistical genetics and epidemiology, he is the Associate Director of the BU Alzheimer’s Disease Research Center (ADRC), Co-Director of Clinical Research of the BU Chronic Traumatic Encephalopathy (CTE) Center and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium and AD Sequencing Project Investigator. His research seeks to understand the genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. He is an internationally recognized expert on CTE, having been a lead or co-author on several of the most highly cited manuscripts and an invited lecturer in national and international venues on the topic. Ongoing research themes include 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service, and dementia-related outcomes and their interaction with genetic factors, 2) clinicopathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 150 research articles, reviews, editorials, and book chapters. He also cares for patients with AD and related dementias, including those at risk for CTE in the BU/Boston Medical Center Memory and Aging Clinic.
He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Mass General Brigham Program in Boston. This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.
Other Positions
- Investigator, Framingham Heart Study
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
Education
- University of Maryland School of Medicine, MD
- Columbia University School of Public Health, MS
- Cornell University, BS
Publications
- Published on 12/6/2024
Nicks R, Shah A, Stathas SA, Kirsch D, Horowitz SM, Saltiel N, Calderazzo SM, Butler MLMD, Cormier KA, Aytan N, Tu-Zahra F, Mathias R, Faheem F, Marcus S, Spurlock E, Fishbein L, Esnault CD, Boden A, Rosen G, Xia W, Daley S, Meng G, Martin BR, Daneshvar DH, Nowinski CJ, Alosco ML, Mez J, Tripodis Y, Huber BR, Alvarez VE, Cherry JD, McKee AC, Stein TD. Neurodegeneration in the cortical sulcus is a feature of chronic traumatic encephalopathy and associated with repetitive head impacts. Acta Neuropathol. 2024 Dec 06; 148(1):79. PMID: 39643767.
Read at: PubMed - Published on 12/2/2024
Abdolmohammadi B, Tuz-Zahra F, Uretsky M, Nicks R, Mosaheb S, Labonte J, Yhang E, Durape S, Martin B, Palmisano J, Nowinski C, Cherry JD, Alvarez VE, Huber BR, Dams-O'Connor K, Crary J, Dwyer B, Daneshvar DH, Goldstein LE, Au R, Katz DI, Kowall NW, Cantu RC, Stern RA, Alosco ML, Stein TD, Tripodis Y, McKee AC, Mez J. Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy. JAMA Netw Open. 2024 Dec 02; 7(12):e2449106. PMID: 39630446.
Read at: PubMed - Published on 11/27/2024
Uretsky M, Nair E, Burton R, Cronin SW, Rousseau D, Tuz-Zahra F, Durape S, Abdolmohammadi B, Baucom Z, Saltiel N, Shah A, Martin B, Palmisano J, Cherry JD, Daneshvar D, Dwyer B, Dams-O'Connor K, Crary J, Goldstein L, Huber B, Katz D, Kowall N, Cantu RC, Alvarez VE, Stern RA, Stein TD, Tripodis Y, McKee AC, Alosco ML, Mez J. Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure. Neurology. 2024 Dec 24; 103(12):e210056. PMID: 39602665.
Read at: PubMed - Published on 11/7/2024
Chaudhuri S, Dempsey DA, Huang YN, Park T, Cao S, Chumin EJ, Craft H, Crane PK, Mukherjee S, Choi SE, Scollard P, Lee M, Nakano C, Mez J, Trittschuh EH, Klinedinst BS, Hohman TJ, Lee JY, Kang KM, Sohn CH, Kim YK, Yi D, Byun MS, Risacher SL, Nho K, Saykin AJ, Lee DY. Association of amyloid and cardiovascular risk with cognition: Findings from KBASE. Alzheimers Dement. 2024 Dec; 20(12):8527-8540. PMID: 39511852.
Read at: PubMed - Published on 11/4/2024
Safransky M, Groh JR, Blennow K, Zetterberg H, Tripodis Y, Martin B, Weller J, Asken BM, Rabinovici GD, Qiu WWQ, McKee AC, Stein TD, Mez J, Henson RL, Long J, Morris JC, Perrin RJ, Schindler SE, Alosco ML. Lumipulse-Measured Cerebrospinal Fluid Biomarkers for the Early Detection of Alzheimer Disease. Neurology. 2024 Dec 10; 103(11):e209866. PMID: 39496102.
Read at: PubMed - Published on 10/15/2024
Yuan J, Tao Q, Ang TFA, Liu C, Devine S, Auerbach SH, Mez J, Farrer LA, Qiu WQ, Au R. The Relationship between Framingham Stroke Risk Profile on Incident Dementia and Alzheimer's Disease: A 40-Year Follow-Up Study Highlighting Female Vulnerability. Ann Neurol. 2024 Dec; 96(6):1124-1134. PMID: 39404028.
Read at: PubMed - Published on 10/1/2024
Kang M, Li C, Mahajan A, Spat-Lemus J, Durape S, Chen J, Gurnani AS, Devine S, Auerbach SH, Ang TFA, Sherva R, Qiu WQ, Lunetta KL, Au R, Farrer LA, Mez J. Subjective Cognitive Decline Plus and Longitudinal Assessment and Risk for Cognitive Impairment. JAMA Psychiatry. 2024 Oct 01; 81(10):993-1002. PMID: 38959008.
Read at: PubMed - Published on 10/1/2024
Miner AE, Groh JR, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Peskind E, Ashton NJ, Gaudet CE, Martin B, Palmisano JN, Banks SJ, Barr WB, Wethe JV, Cantu RC, Dodick DW, Katz DI, Mez J, van Amerongen S, Cummings JL, Shenton ME, Reiman EM, Stern RA, Alosco ML. Examination of plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in former elite American football players. Alzheimers Dement. 2024 Nov; 20(11):7529-7546. PMID: 39351900.
Read at: PubMed - Published on 9/22/2024
Groh JR, Yhang E, Tripodis Y, Palminsano J, Martin B, Burke E, Bhatia U, Mez J, Stern RA, Gunstad J, Alosco ML. Health outcomes of former division I college athletes. Brain Inj. 2025 Jan 28; 39(2):88-98. PMID: 39306858.
Read at: PubMed - Published on 9/16/2024
Chen J, Ragab AAY, Doyle MF, Alosco ML, Fang Y, Mez J, Satizabal CL, Qiu WQ, Murabito JM, Lunetta KL. Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort. Alzheimers Dement. 2024 Nov; 20(11):7465-7478. PMID: 39282876.
Read at: PubMed
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