Jesse B. Mez, MD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jesse Mez, MD, MS, is an Associate Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine. A neurologist with clinical training in aging and dementia and research training in biostatistics/statistical genetics and epidemiology, he is the Associate Director of the BU Alzheimer’s Disease Research Center (ADRC), Co-Director of Clinical Research of the BU Chronic Traumatic Encephalopathy (CTE) Center and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium and AD Sequencing Project Investigator. His research seeks to understand the genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. He is an internationally recognized expert on CTE, having been a lead or co-author on several of the most highly cited manuscripts and an invited lecturer in national and international venues on the topic. Ongoing research themes include 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service, and dementia-related outcomes and their interaction with genetic factors, 2) clinicopathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 150 research articles, reviews, editorials, and book chapters. He also cares for patients with AD and related dementias, including those at risk for CTE in the BU/Boston Medical Center Memory and Aging Clinic.

He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Mass General Brigham Program in Boston. This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.

Publications

  • Published 4/22/2025

    Ding H, Madan S, Searls E, McNulty M, Low S, Li Z, Ho K, Rahman S, Igwe A, Popp Z, Hwang PH, De Anda-Duran I, Kolachalama VB, Mez J, Alosco ML, Thomas RJ, Au R, Lin H. Exploring nightly variability and clinical influences on sleep measures: insights from a digital brain health platform. Sleep Med. 2025 Jul; 131:106532. PMID: 40306226.

    Read at: PubMed

  • Published 4/21/2025

    van Amerongen S, Peskind ER, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Alosco ML, Katz D, Banks SJ, Barr WB, Cantu RC, Dodick DW, Geda YE, Mez J, Wethe JV, Weller JL, Daneshvar DH, Palmisano J, Fagle T, Holleck M, Kossow B, Pulukuri S, Tuz-Zahra F, Colasurdo E, Sikkema C, Iliff J, Li G, Shenton ME, Reiman EM, Cummings JL, Stern RA. Catecholamine Dysregulation in Former American Football Players: Findings From the DIAGNOSE CTE Research Project. Neurology. 2025 May 27; 104(10):e213584. PMID: 40258206.

    Read at: PubMed

  • Published 4/9/2025

    Han X, Zhang Y, Petrosky JN, Bald S, Sherva RM, Labadorf A, Cherry JD, Chung J, Farrell K, Abdolmohammadi B, Durape S, Martin BM, Palmisano JN, Farrell JJ, Alvarez VE, Huber BR, Dwyer B, Daneshvar DH, Dams-O'Connor K, Jun GR, Lunetta KL, Goldstein LE, Katz DI, Cantu RC, Shenton ME, Cummings JL, Reiman EM, Stern RA, Alosco ML, Tripodis Y, Farrer LA, Stein TD, Crary JF, McKee AC, Mez J. A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. Cell Rep Med. 2025 Apr 09; 102084. PMID: 40239644.

    Read at: PubMed

  • Published 4/1/2025

    Cao Y, Salvati LR, Chen J, Ragab A, Mez J, Satizabal CL, Alosco ML, Fang Y, Qiu WQ, Lunetta KL, Murabito JM, Doyle MF. The Association of Circulating Immune Cells with Cognitive Function, Brain Imaging, and Incident all-cause and Alzheimer's Dementia: The Framingham Offspring Study. J Gerontol A Biol Sci Med Sci. 2025 Apr 01. PMID: 40168089.

    Read at: PubMed

  • Published 3/31/2025

    Hayes-Larson E, Andrews RM, Kezios KL, Bercu A, Rouanet A, Helmer C, Crane PK, Gibbons L, Klinedinst BS, McEvoy LK, Nichols E, Weuve J, Rajan KB, Hwang PH, Mez J, Farina M, Shaw C, Sims KD, Therneau T, Petersen RC, Bouteloup V, Gross A, Albert M, Morris JC, Masters CL, Resnick SM, Maruff P, Manly JJ, Turney I, Vonk JMJ, Avila-Rieger J, Weigand A, Chen R, Wang J, Proust-Lima C, Mayeda ER. Approaches to timescale choice in cognitive aging research and potential implications for estimated exposure effects: coordinated analyses in ten cohorts of older adults. Epidemiology. 2025 Mar 31. PMID: 40164562.

    Read at: PubMed

View All 191 Publications:   View Full Profile in BUMC

Other Positions

  • Investigator
    Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Maryland School of Medicine, MD
  • Columbia University School of Public Health, MS
  • Cornell University, BS

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