Jesse B. Mez, MD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jesse Mez, MD, MS, is an Associate Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine. A neurologist with clinical training in aging and dementia and research training in biostatistics/statistical genetics and epidemiology, he is the Associate Director of the BU Alzheimer’s Disease Research Center (ADRC), Co-Director of Clinical Research of the BU Chronic Traumatic Encephalopathy (CTE) Center and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium and AD Sequencing Project Investigator. His research seeks to understand the genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. He is an internationally recognized expert on CTE, having been a lead or co-author on several of the most highly cited manuscripts and an invited lecturer in national and international venues on the topic. Ongoing research themes include 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service, and dementia-related outcomes and their interaction with genetic factors, 2) clinicopathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 150 research articles, reviews, editorials, and book chapters. He also cares for patients with AD and related dementias, including those at risk for CTE in the BU/Boston Medical Center Memory and Aging Clinic.

He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Mass General Brigham Program in Boston. This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.

Publications

Published 10/1/2025

Logue MW, Labadorf A, O'Neill NK, Dickson DW, Dugger BN, Flanagan ME, Frosch MP, Gearing M, Jin LW, Kofler J, Mayeux R, McKee A, Miller CA, Murray ME, Nelson PT, Perrin RJ, Schneider JA, Stein TD, Teich AF, Tobunluepop K, Troncoso JC, Wang SH, Wang Z, Wolozin B, Mez J, Farrer LA. Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors. Alzheimers Dement. 2025 Oct; 21(10):e70629. PMID: 41059714.

Read at: PubMed
Published 10/1/2025

Marino FR, Rogers G, Miller JW, Selhub J, Mez J, Crane PK, Mukherjee S, Saykin AJ, Hohman TJ, Trittschuh EH, Au R, Jacques PF, Hwang PH. Higher vitamin B12 from mid- to late life is related to slower rates of cognitive decline. Alzheimers Dement. 2025 Oct; 21(10):e70864. PMID: 41152187.

Read at: PubMed
Published 9/27/2025

Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush W, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GC, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations. medRxiv. 2025 Sep 27. PMID: 41040715.

Read at: PubMed
Published 9/1/2025

Gallée J, Gibbons LE, Choi SE, Lee M, Scollard P, Trittschuh EH, Mez J, Saykin AJ, Foldi NS, Mukherjee S, Crane PK. Facets of language performance in early-onset and late-onset Alzheimer's disease dementia. Alzheimers Dement. 2025 Sep; 21(9):e70705. PMID: 40990522.

Read at: PubMed
Published 9/1/2025

Choi SE, Mukherjee S, Gibbons LE, Trittschuh EH, Lee M, Scollard P, Sanders RE, Snitz BE, Shaaban CE, Lopez OL, Mez J, Saykin AJ, Hohman TJ, Crane PK. Beyond NACC's Uniform Data Set for cognition: the impact of additional items on measurement precision. Alzheimers Dement. 2025 Sep; 21(9):e70694. PMID: 40960068.

Read at: PubMed

Other Positions

Investigator
Framingham Heart Study
Member, Evans Center for Interdisciplinary Biomedical Research
Boston University

Websites

Education

University of Maryland School of Medicine, MD
Columbia University School of Public Health, MS
Cornell University, BS

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