Jeffrey R. Moore, PhD

Adjunct Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.

Publications

  • Published 2/2/2026

    Cuoco L, Gill SE, Francois L, Souders S, DeMasi C, Moore JR, Chain FJJ. Genetic suppressor of autophagy defects in huntingtin null cells identified using a mutagenesis screen in Dictyostelium discoideum. BMC Mol Cell Biol. 2026 Feb 02; 27(1). PMID: 41629784.

    Read at: PubMed

  • Published 10/30/2025

    Konow N, Reder B, Bartlett D, Jenness D, Patel T, Moore JR, Brocklehurst RJ. Rat superficial masseter operates at long lengths during biting. Sci Rep. 2025 Oct 30; 15(1):37978. PMID: 41168355.

    Read at: PubMed

  • Published 3/6/2025

    Barry ME, Rynkiewicz MJ, Wen J, Tu AY, Regnier M, Lehman W, Moore JR. Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms. Arch Biochem Biophys. 2025 Jun; 768:110380. PMID: 40057222.

    Read at: PubMed

  • Published 12/16/2024

    Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants. J Clin Invest. 2024 Dec 16; 134(24). PMID: 39436707.

    Read at: PubMed

  • Published 8/30/2024

    Creso JG, Gokhan I, Rynkiewicz MJ, Lehman W, Moore JR, Campbell SG. In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R. Front Physiol. 2024; 15:1452509. PMID: 39282088.

    Read at: PubMed

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Websites

Education

  • University of Vermont, PhD
  • University of Massachusetts Lowell, MS
  • University of Massachusetts Lowell, BS

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