Jeffrey R. Moore, PhD

Adjunct Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.

Publications

  • Published 3/6/2025

    Barry ME, Rynkiewicz MJ, Wen J, Tu AY, Regnier M, Lehman W, Moore JR. Dual role of Tropomyosin-R160 in thin filament regulation: Insights into phosphorylation-dependent cardiac relaxation and cardiomyopathy mechanisms. Arch Biochem Biophys. 2025 Jun; 768:110380. PMID: 40057222.

    Read at: PubMed

  • Published 12/16/2024

    Halder SS, Rynkiewicz MJ, Kim L, Barry ME, Zied AG, Sewanan LR, Kirk JA, Moore JR, Lehman WJ, Campbell SG. Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy-associated TPM1 variants. J Clin Invest. 2024 Dec 16; 134(24). PMID: 39436707.

    Read at: PubMed

  • Published 8/30/2024

    Creso JG, Gokhan I, Rynkiewicz MJ, Lehman W, Moore JR, Campbell SG. In silico and in vitro models reveal the molecular mechanisms of hypocontractility caused by TPM1 M8R. Front Physiol. 2024; 15:1452509. PMID: 39282088.

    Read at: PubMed

  • Published 1/22/2024

    Barry ME, Rynkiewicz MJ, Pavadai E, Viana A, Lehman W, Moore JR. Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. J Mol Cell Cardiol. 2024 Mar; 188:30-37. PMID: 38266978.

    Read at: PubMed

  • Published 1/21/2023

    Halder SS, Rynkiewicz MJ, Creso JG, Sewanan LR, Howland L, Moore JR, Lehman W, Campbell SG. Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. PNAS Nexus. 2023 Mar; 2(3):pgad011. PMID: 36896133.

    Read at: PubMed

View All 64 Publications:   View Full Profile in BUMC

Websites

Education

  • University of Vermont, PhD
  • University of Massachusetts Lowell, MS
  • University of Massachusetts Lowell, BS

View all profiles