James W. Holsapple, MD

Chair , Neurosurgery

James Holsapple
88 E. Newton St Newton Pavilion


James Holsapple, MD, has been an associate professor of neurosurgery and pediatrics at BMC/BUSM since 2009. Holsapple received his undergraduate degree from Drake University, Magna Cum Laude, and his MD from University of Kansas School of Medicine. He completed an internal medicine internship at St. Luke’s Hospital, Kansas City, Missouri and a general surgery internship and neurological surgery residency at Upstate Medical University (SUNY), where he was also a NRSA Research Fellow in the Departments of Neurological Surgery and Physiology. He then joined the faculty and was promoted to Associate Professor of Neurological Surgery and Pediatrics.

A resident of South Boston, Holsapple is a member of the New England Neurological Society, the Congress of Neurological Surgeons and the American Association of Neurological Surgeons. The author of numerous papers, peer-reviewed articles, chapters and case reports, his research interests include primate visual and motor processing, human brain tumor management and biology. Holsapple’s clinical interests include adult intracranial tumors, vascular surgery and pediatric neurosurgery.

Other Positions

  • Associate Professor, Neurosurgery, Boston University Chobanian & Avedisian School of Medicine


  • University of Kansas, MD
  • Drake University, BA

Classes Taught

  • GMSMS571
  • GMSMS572


  • Published on 9/5/2023

    Rizzo R, Wang JWJL, DePold Hohler A, Holsapple JW, Vaou OE, Ivanov PC. Dynamic networks of cortico-muscular interactions in sleep and neurodegenerative disorders. Front Netw Physiol. 2023; 3:1168677. PMID: 37744179.

    Read at: PubMed
  • Published on 2/10/2023

    Ravina K, Yang N, Brocoum S, Pasco-Anderson J, Walker RL, Khan M, Cabodi M, Holsapple J. Conical drill bit for optimized external ventricular drain placement: a proof-of-concept study. J Neurosurg. 2023 Sep 01; 139(3):881-891. PMID: 36790016.

    Read at: PubMed
  • Published on 7/1/2020

    Lee S, Kwok N, Holsapple J, Heldt T, Bourouiba L. Enhanced wall shear stress prevents obstruction by astrocytes in ventricular catheters. J R Soc Interface. 2020 07; 17(168):20190884. PMID: 32603649.

    Read at: PubMed
  • Published on 1/29/2020

    Haider G, Omofoye OA, Holsapple JW. Intracranial Hypertension Following Gunshot Wound to the Torcula: Case Report and Literature Review. World Neurosurg. 2020 05; 137:94-97. PMID: 32006734.

    Read at: PubMed
  • Published on 12/25/2019

    Jaishankar R, Fanelli A, Filippidis A, Vu T, Holsapple J, Heldt T. A Spectral Approach to Model-Based Noninvasive Intracranial Pressure Estimation. IEEE J Biomed Health Inform. 2020 08; 24(8):2398-2406. PMID: 31880569.

    Read at: PubMed
  • Published on 7/1/2019

    Jaishankar R, Fanelli A, Filippidis A, Vu T, Holsapple J, Heldt T. A Frequency-domain Approach to Noninvasive Intracranial Pressure Estimation. Conf Proc IEEE Eng Med Biol Soc. 2019 07; 2019:5055-5058. PMID: 31946995.

    Read at: PubMed
  • Published on 6/13/2019

    Mackel CE, Devaiah A, Holsapple J, Moore JM. Neural Crest Cell Failure as Embryogenesis for Fusiform Aneurysm of the Anterior Communicating Artery: Case Report and Review of the Literature. World Neurosurg. 2019 Sep; 129:232-236. PMID: 31203061.

    Read at: PubMed
  • Published on 1/1/2018

    Fanelli A, Jaishankar R, Filippidis A, Holsapple J, Heldt T. A Waveform Archiving System for the GE Solar 8000i Bedside Monitor. Acta Neurochir Suppl. 2018; 126:173-177. PMID: 29492556.

    Read at: PubMed
  • Published on 4/4/2017

    Filippidis AS, Conroy TJ, Maragkos GA, Holsapple JW, Davies KG. Intraocular Silicone Oil Migration into the Ventricles Resembling Intraventricular Hemorrhage: Case Report and Review of the Literature. World Neurosurg. 2017 Jun; 102:695.e7-695.e10. PMID: 28385656.

    Read at: PubMed
  • Published on 3/28/2017

    Mian AZ, Edasery D, Sakai O, Mustafa Qureshi M, Holsapple J, Nguyen T. Radiological imaging features of the basal ganglia that may predict progression to hemicraniectomy in large territory middle cerebral artery infarct. Neuroradiology. 2017 May; 59(5):477-484. PMID: 28353064.

    Read at: PubMed

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