Jacqueline Sharon, PhD

Emeritus Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jacqueline Sharon, PhD is a current Professor of Pathology and Laboratory Medicine at the Chobanian and Avedisian School of Medicine. After earning her PhD at Columbia University, she completed a Postdoc at Harvard University. She currently receives funding from the National Institutes of Health for her research on B Cell Epitope Discovery and Mechanisms of Antibody Protection. Dr. Sharon's laboratory is interested in the development of vaccines and immunotherapeutics against bacterial pathogens. Current research focuses on the discovery and validation of antigens and epitopes that induce protective antibodies to Francisella tularensis, a Gram negative facultative intracellular bacterium that causes tularemia.

Publications

  • Published 8/1/2014

    Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Roche MI, Seaton BA, Sharon J. Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity. Monoclon Antib Immunodiagn Immunother. 2014 Aug; 33(4):235-45. PMID: 25171003.

    Read at: PubMed

  • Published 6/26/2014

    Lu Z, Rynkiewicz MJ, Madico G, Li S, Yang CY, Perkins HM, Sompuram SR, Kodela V, Liu T, Morris T, Wang D, Roche MI, Seaton BA, Sharon J. B-cell epitopes in GroEL of Francisella tularensis. PLoS One. 2014; 9(6):e99847. PMID: 24968190.

    Read at: PubMed

  • Published 5/1/2014

    Sharon J, Rynkiewicz MJ, Lu Z, Yang CY. Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics. Immunology. 2014 May; 142(1):1-23. PMID: 24219801.

    Read at: PubMed

  • Published 12/18/2013

    Lu Z, Perkins HM, Sharon J. Antibodies to both terminal and internal B-cell epitopes of Francisella tularensis O-polysaccharide produced by patients with tularemia. Clin Vaccine Immunol. 2014 Feb; 21(2):227-33. PMID: 24351753.

    Read at: PubMed

  • Published 11/1/2013

    Lu Z, Rynkiewicz MJ, Yang CY, Madico G, Perkins HM, Wang Q, Costello CE, Zaia J, Seaton BA, Sharon J. The binding sites of monoclonal antibodies to the non-reducing end of Francisella tularensis O-antigen accommodate mainly the terminal saccharide. Immunology. 2013 Nov; 140(3):374-89. PMID: 23844703.

    Read at: PubMed

View All 55 Publications:   View Full Profile in BUMC

Other Positions

  • Research Associate Professor, Biochemistry & Cell Biology
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Columbia University, PhD
  • Columbia University, MPhil
  • Queens College, City University of New York, MA
  • Queens College, City University of New York, BA

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