Irving J. Bigio, PhD

Professor, Biomedical Engineering

Irving Bigio
44 Cummington St


Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Other Positions

  • Professor, Gastroenterology, Medicine, Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University


  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, MS
  • University of Michigan at Ann Arbor, BS


  • Published on 3/21/2024

    Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Res Sq. 2024 Mar 21. PMID: 38562721.

    Read at: PubMed
  • Published on 10/27/2023

    Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer's disease. Alzheimers Res Ther. 2023 Oct 27; 15(1):185. PMID: 37891618.

    Read at: PubMed
  • Published on 10/24/2023

    Blanke N, Chang S, Novoseltseva A, Wang H, Boas DA, Bigio IJ. Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy. Biomed Opt Express. 2023 Nov 01; 14(11):5946-5964. PMID: 38021128.

    Read at: PubMed
  • Published on 10/11/2023

    Manolakos D, Patrick G, Geisse JK, Rabinovitz H, Buchanan K, Hoang P, Rodriguez-Diaz E, Bigio IJ, Cognetta AB. Use of an elastic-scattering spectroscopy and artificial intelligence device in the assessment of lesions suggestive of skin cancer: A comparative effectiveness study. JAAD Int. 2024 Mar; 14:52-58. PMID: 38143790.

    Read at: PubMed
  • Published on 8/29/2023

    Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive Mechanical and Structural Changes in Anterior Cerebral Arteries with Alzheimer's Disease. Res Sq. 2023 Aug 29. PMID: 37693508.

    Read at: PubMed
  • Published on 7/18/2021

    Rodriguez-Diaz E, Kaanan S, Vanley C, Qureshi T, Bigio IJ. Toward optical spectroscopy-guided lung biopsy: Demonstration of tissue-type classification. J Biophotonics. 2021 10; 14(10):e202100132. PMID: 34245106.

    Read at: PubMed
  • Published on 3/24/2021

    Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK. Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy. Dig Dis Sci. 2022 02; 67(2):613-621. PMID: 33761089.

    Read at: PubMed
  • Published on 3/22/2021

    Blanke N, Go V, Rosene DL, Bigio IJ. Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey. Neurophotonics. 2021 Jan; 8(1):015010. PMID: 33763502.

    Read at: PubMed
  • Published on 2/9/2021

    Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303. PMID: 33578267.

    Read at: PubMed
  • Published on 3/12/2020

    Raufer S, Idoff C, Zosuls A, Marino G, Blanke N, Bigio IJ, O'Malley JT, Burgess BJ, Nadol JB, Guinan JJ, Nakajima HH. Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion. J Assoc Res Otolaryngol. 2020 04; 21(2):171-182. PMID: 32166603.

    Read at: PubMed

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