Irving J. Bigio, PhD

Professor, Biomedical Engineering

Irving Bigio
44 Cummington St


Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Other Positions

  • Professor, Gastroenterology, Medicine, Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University


  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, MS
  • University of Michigan at Ann Arbor, BS


  • Published on 8/29/2023

    Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive Mechanical and Structural Changes in Anterior Cerebral Arteries with Alzheimer's Disease. Res Sq. 2023 Aug 29. PMID: 37693508.

    Read at: PubMed
  • Published on 7/18/2021

    Rodriguez-Diaz E, Kaanan S, Vanley C, Qureshi T, Bigio IJ. Toward optical spectroscopy-guided lung biopsy: Demonstration of tissue-type classification. J Biophotonics. 2021 10; 14(10):e202100132. PMID: 34245106.

    Read at: PubMed
  • Published on 3/24/2021

    Rodriguez-Diaz E, Jepeal LI, Baffy G, Lo WK, MashimoMD H, A'amar O, Bigio IJ, Singh SK. Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy. Dig Dis Sci. 2022 02; 67(2):613-621. PMID: 33761089.

    Read at: PubMed
  • Published on 3/22/2021

    Blanke N, Go V, Rosene DL, Bigio IJ. Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey. Neurophotonics. 2021 Jan; 8(1):015010. PMID: 33763502.

    Read at: PubMed
  • Published on 2/9/2021

    Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303. PMID: 33578267.

    Read at: PubMed
  • Published on 3/12/2020

    Raufer S, Idoff C, Zosuls A, Marino G, Blanke N, Bigio IJ, O'Malley JT, Burgess BJ, Nadol JB, Guinan JJ, Nakajima HH. Anatomy of the Human Osseous Spiral Lamina and Cochlear Partition Bridge: Relevance for Cochlear Partition Motion. J Assoc Res Otolaryngol. 2020 04; 21(2):171-182. PMID: 32166603.

    Read at: PubMed
  • Published on 8/24/2019

    Rodriguez-Diaz E, Manolakos D, Christman H, Bonning MA, Geisse JK, A'Amar OM, Leffell DJ, Bigio IJ. Optical Spectroscopy as a Method for Skin Cancer Risk Assessment. Photochem Photobiol. 2019 11; 95(6):1441-1445. PMID: 31287160.

    Read at: PubMed
  • Published on 5/9/2019

    Belghasem ME, A'amar O, Roth D, Walker J, Arinze N, Richards SM, Francis JM, Salant DJ, Chitalia VC, Bigio IJ. Towards minimally-invasive, quantitative assessment of chronic kidney disease using optical spectroscopy. Sci Rep. 2019 05 09; 9(1):7168. PMID: 31073168.

    Read at: PubMed
  • Published on 4/10/2019

    Sharaha U, Rodriguez-Diaz E, Sagi O, Riesenberg K, Salman A, Bigio IJ, Huleihel M. Fast and reliable determination of Escherichia coli susceptibility to antibiotics: Infrared microscopy in tandem with machine learning algorithms. J Biophotonics. 2019 07; 12(7):e201800478. PMID: 30916881.

    Read at: PubMed
  • Published on 1/25/2019

    Sharaha U, Rodriguez-Diaz E, Sagi O, Riesenberg K, Lapidot I, Segal Y, Bigio IJ, Huleihel M, Salman A. Detection of Extended-Spectrum ß-Lactamase-Producing Escherichia coli Using Infrared Microscopy and Machine-Learning Algorithms. Anal Chem. 2019 02 05; 91(3):2525-2530. PMID: 30681832.

    Read at: PubMed

View 79 more publications: View full profile at BUMC

View all profiles