Irving J. Bigio, PhD Professor, Boston University College of Engineering Biography Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering. Publications Published 9/3/2025 Halvorsen SC, Gkousioudi A, Nicks R, Alvarez VE, Bigio IJ, Zaia J, Stein TD, Zhang Y. Cerebrovascular remodeling in aging and neurodegenerative disease progression. Front Bioeng Biotechnol. 2025; 13:1597917. PMID: 40969224. Read at: PubMed Published 8/13/2025 Abdelhakeem AA, Chang S, Novoseltseva A, Hyman M, Mckee AC, Bigio IJ, Boas DA, Huber BR, Wang H. Quantitative analysis of lipofuscin in neurodegenerative diseases using serial sectioning two-photon microscopy and fluorescence lifetime imaging microscopy. Neurophotonics. 2025 Jul; 12(3):035007. PMID: 40809089. Read at: PubMed Published 8/1/2025 Novoseltseva A, Kureli G, Chang S, Yang J, Antinew PD, Chandra A, Berghol S, Spurlock E, McKee AC, Huber B, Wang H, Boas DA, Bigio IJ. Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy. Alzheimers Dement. 2025 Aug; 21(8):e70582. PMID: 40843933. Read at: PubMed Published 7/14/2025 Aslan M, Gray AJ, Packard L, Giorgetta C, Bigio IJ, Ünlü MS. Impact of uniform illumination in widefield microscopy and mesoscopy. Sci Rep. 2025 Jul 14; 15(1):25400. PMID: 40659689. Read at: PubMed Published 3/5/2025 Krisciunas GP, Rodriguez-Diaz E, Berry L, Spokas G, A'Amar OM, Couey M, Edwards H, Gooey J, Hanks J, Lu Z, Lucas D, O'Leary M, Pistey R, Sakharkar M, Sayre K, Tracy J, Zhao G, Bigio IJ, Grillone GA. Elastic scattering spectroscopy for intraoperative oral cancer mucosal margin guidance: Initial results from a 104 patient cohort. Am J Otolaryngol. 2025; 46(3):104605. PMID: 40058291. Read at: PubMed View All 101 Publications: View Full Profile in BUMC Other Positions Professor, MedicineBoston University Chobanian & Avedisian School of Medicine Member, BU-BMC Cancer CenterBoston University Member, Evans Center for Interdisciplinary Biomedical ResearchBoston University Websites BU Profile Biomedical Engineering Faculty College of Engineering Faculty Biomedical Optics Lab The International Society for Optics and Photonics LinkedIn Google Scholar Education University of Michigan at Ann Arbor, PhD University of Michigan at Ann Arbor, PhD University of Michigan at Ann Arbor, MS University of Michigan at Ann Arbor, BS View all profiles