Irving J. Bigio, PhD

Professor, Boston University College of Engineering

Biography

Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Publications

  • Published 3/5/2025

    Krisciunas GP, Rodriguez-Diaz E, Berry L, Spokas G, A'Amar OM, Couey M, Edwards H, Gooey J, Hanks J, Lu Z, Lucas D, O'Leary M, Pistey R, Sakharkar M, Sayre K, Tracy J, Zhao G, Bigio IJ, Grillone GA. Elastic scattering spectroscopy for intraoperative oral cancer mucosal margin guidance: Initial results from a 104 patient cohort. Am J Otolaryngol. 2025; 46(3):104605. PMID: 40058291.

    Read at: PubMed

  • Published 1/20/2025

    Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography. Light Sci Appl. 2025 Jan 20; 14(1):57. PMID: 39833166.

    Read at: PubMed

  • Published 12/24/2024

    Sakharkar M, Spokas G, Berry L, Daniels K, Nithagon P, Rodriguez-Diaz E, Tracy L, Noordzij JP, Bigio I, Grillone G, Krisciunas GP. Non-invasive screening for laryngeal cancer using the oral cavity as a proxy for differentiation of laryngeal cancer versus leukoplakia: A novel application of ESS technology and artificial intelligence supported statistical modeling. Am J Otolaryngol. 2025; 46(1):104581. PMID: 39742670.

    Read at: PubMed

  • Published 3/21/2024

    Cheng S, Chang S, Li Y, Novoseltseva A, Lin S, Wu Y, Zhu J, McKee AC, Rosene DL, Wang H, Bigio IJ, Boas DA, Tian L. Enhanced Multiscale Human Brain Imaging by Semi-supervised Digital Staining and Serial Sectioning Optical Coherence Tomography. Res Sq. 2024 Mar 21. PMID: 38562721.

    Read at: PubMed

  • Published 10/27/2023

    Liu X, Halvorsen S, Blanke N, Downs M, Stein TD, Bigio IJ, Zaia J, Zhang Y. Progressive mechanical and structural changes in anterior cerebral arteries with Alzheimer's disease. Alzheimers Res Ther. 2023 Oct 27; 15(1):185. PMID: 37891618.

    Read at: PubMed

Other Positions

  • Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Education

  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, MS
  • University of Michigan at Ann Arbor, BS