Irving J. Bigio, PhD

Professor, Boston University College of Engineering

Biography

Dr. Irving Bigio has been a professor of Biomedical Engineering, and Electrical & Computer Engineering, at Boston University for the past 22 years. His is primarily interested in using biomedical optics to develop clinical and research applications of optical technologies. His lab was founded in 2001 and focuses on clinical diagnostics based on elastic scattering spectroscopy, on laboratory applications to monitor sub-cellular dynamics in vitro, and novel methods to image neuronal activation patterns in label-free neural tissues. He has mentored numerous graduate and undergraduate students and in 2010 he received a Distinguished Lecturer Award from the Boston University College of Engineering.

Publications

  • Published 6/16/2026

    Xie T, Novoseltseva A, Gray AJ, Bradsby M, Bigio IJ. Measurement of the absolute value of the optical birefringence of myelin in primate brain tissue. Neurophotonics. 2026 Apr; 13(2):025011. PMID: 42326435.

    Read at: PubMed

  • Published 5/23/2026

    Aggouras AN, Lim MT, Bradsby M, Bigio IJ, Eyckmans J, Connizzo BK. An Ex Vivo Model of Laser-Induced Microdamage to Study Tendon Repair. Tissue Eng Part A. 2026 May 23; 19373341261449863. PMID: 42175761.

    Read at: PubMed

  • Published 4/14/2026

    Sakharkar M, Spokas G, Jalihal P, Berry L, Rodriguez-Diaz E, Bigio IJ, Grillone GA, Krisciunas GP. A prospective cohort study testing whether oral cavity mucosal tissue variability influences elastic scattering spectroscopy (ESS) measures. Am J Otolaryngol. 2026; 47(3):104836. PMID: 42001561.

    Read at: PubMed

  • Published 3/24/2026

    Lotfollahzadeh S, Jalihal P, A'amar O, Chung JY, Howard M, Oros E, Rodriguez-Diaz E, Belghasem M, Kumar A, Malik S, Francis J, Chitalia VC, Bigio IJ. Quantitative Assessment of Kidney Interstitial Fibrosis Using Optical Spectroscopy Mediated through a Fine Needle Probe. Kidney360. 2026 Jul 01; 7(7):1463-1474. PMID: 41874566.

    Read at: PubMed

  • Published 11/4/2025

    Novoseltseva A, Chandra A, Gray AJ, Li S, Bradsby M, Bigio IJ. Accelerating myelin defect detection in neurodegenerative disorders: a human-in-the-loop deep learning approach with birefringence microscopy. Neurophotonics. 2025 Oct; 12(4):045007. PMID: 41195092.

    Read at: PubMed

View All 108 Publications:   View Full Profile in BUMC

Other Positions

  • Professor, Medicine
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, PhD
  • University of Michigan at Ann Arbor, MS
  • University of Michigan at Ann Arbor, BS

View all profiles