Hoon Ryu, PhD
Adjunct Associate Professor, Neurology
Biography
Dr. Hoon Ryu earned his doctoral degree from Chonbuk National University, South Korea. He completed a postdoctoral research fellowship and was appointed Instructor of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 1999. He joined the Chobanian and Avedisian School of Medicine’s Department of Neurology in 2004 as an Assistant Professor. Now he is an Associate Professor and an investigator with the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. He is a director of the laboratory for Neuronal Gene Regulation and Epigenetics. He works on the identification of biomarkers, the determination of molecular genetic, epigenetic mechanisms, and the development of therapeutics using cell culture systems and animal models of neurodegeneration. He has published over 70 original reports.
Research Interests:
Epigenetic changes encompass an array of molecular modifications including DNA methylation and changes to the chromatin packaging of DNA by post-translational histone modifications. The structure, dynamics, and chemical properties of chromatin almost completely determines how, when, and which genes are turned on and off. Chromatin remodeling and transcription regulation are tightly controlled under physiological conditions. Deregulation of chromatin remodeling is linked to the pathogenesis of neurodegenerative disorders but the mechanism is elusive. In order to identify how genomes are deregulated by heterochromatin, Dr. Ryu is performing ChIP genome-wide sequencing combined with RNA-sequencing followed by platform integration analysis. He has found that altered chromatin plasticity is closely linked to the pathogenesis of Huntington’s disease via an expression of ESET (ERG-associated protein with a SET domain), a histone H3K9-specific methyltransferase. Currently, he is conducting research about mechanisms of ESET gene induction and neuronal heterochromatin condensation in Alzheimer’s disease.
Other Positions
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- VA Boston Healthcare System
Websites
Education
- Chonbuk National University, PhD
- Chonbuk National University, MS
- Chonbuk National University, BS
Publications
- Published on 2/7/2025
Yousefian-Jazi A, Kim S, Chu J, Choi SH, Nguyen PTT, Park U, Kim MG, Hwang H, Lee K, Kim Y, Hyeon SJ, Rhim H, Ryu HL, Lim G, Stein TD, Lim K, Ryu H, Lee J. Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice. Mol Neurodegener. 2025 Feb 07; 20(1):16. PMID: 39920775.
Read at: PubMed - Published on 1/15/2025
Bhalla M, Joo J, Kim D, Shin JI, Park YM, Ju YH, Park U, Yoo S, Hyeon SJ, Lee H, Lee J, Ryu H, Lee CJ. SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer's disease. Mol Neurodegener. 2025 Jan 15; 20(1):6. PMID: 39815261.
Read at: PubMed - Published on 12/8/2024
Kim JH, Jeong HG, Hyeon SJ, Park U, Oh WJ, Hwang J, Lim HH, Ko PW, Lee HW, Lee WH, Ryu H, Suk K. Crosstalk between lipocalin-2 and IL-6 in traumatic brain injury: Closely related biomarkers. Exp Neurol. 2025 Mar; 385:115092. PMID: 39637963.
Read at: PubMed - Published on 9/24/2024
Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24; 148(1):46. PMID: 39316141.
Read at: PubMed - Published on 7/23/2024
Kim S, Chun H, Kim Y, Kim Y, Park U, Chu J, Bhalla M, Choi SH, Yousefian-Jazi A, Kim S, Hyeon SJ, Kim S, Kim Y, Ju YH, Lee SE, Lee H, Lee K, Oh SJ, Hwang EM, Lee J, Lee CJ, Ryu H. Astrocytic autophagy plasticity modulates Aß clearance and cognitive function in Alzheimer's disease. Mol Neurodegener. 2024 Jul 23; 19(1):55. PMID: 39044253.
Read at: PubMed - Published on 7/17/2024
Yousefian-Jazi A, Kim S, Choi SH, Chu J, Nguyen PT, Park U, Lim K, Hwang H, Lee K, Kim Y, Hyeon SJ, Rhim H, Ryu HL, Lim G, Stein TD, Ryu H, Lee J. Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice. bioRxiv. 2024 Jul 17. PMID: 39071309.
Read at: PubMed - Published on 5/3/2024
Kim D, Ko HY, Chung JI, Park YM, Lee S, Kim SY, Kim J, Chun JH, Han KS, Lee M, Ju YH, Park SJ, Park KD, Nam MH, Kim SH, Shim JK, Park Y, Lim H, Park J, Lee GH, Kim H, Kim S, Park U, Ryu H, Lee SY, Park S, Kang SG, Chang JH, Lee CJ, Yun M. Visualizing cancer-originating acetate uptake through monocarboxylate transporter 1 in reactive astrocytes in the glioblastoma tumor microenvironment. Neuro Oncol. 2024 May 03; 26(5):843-857. PMID: 38085571.
Read at: PubMed - Published on 5/2/2024
Kang JH, Yoon T, Lee C, Lim S, Ryu H. Design of high-performance entangling logic in silicon quantum dot systems with Bayesian optimization. Sci Rep. 2024 May 02; 14(1):10080. PMID: 38698015.
Read at: PubMed - Published on 4/15/2024
Cho A, Oh SY, Lee H, Ryu HG. VASOPRESSOR REDUCTION EFFECT OF POLYMYXIN B HEMOPERFUSION IN PATIENTS WITH PERITONITIS-INDUCED SEPTIC SHOCK: A PROPENSITY SCORE-MATCHED ANALYSIS. Shock. 2024 Jul 01; 62(1):69-73. PMID: 38661146.
Read at: PubMed - Published on 4/6/2024
Lim L, Park SJ, Kang C, Oh SY, Ryu HG, Lee H. Perioperative urinary ketosis and metabolic acidosis in patients fasted for undergoing gynecologic surgery. Acta Anaesthesiol Scand. 2024 Aug; 68(7):913-922. PMID: 38581223.
Read at: PubMed
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