Honghuang Lin, PhD

Adjunct Associate Professor, Medicine

Honghuang Lin
617.358.0091
72 East Concord St

Biography

I am a bioinformatician/biostatistician with training in mathematics, machine learning, genetics, and digital medicine. Our lab is mainly focused on the development and application of computational tools to study complex diseases.

1. Identification of genetic causes of complex diseases. We have been involved in multiple large-scale genetic consortiums, such as the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Trans-Omics for Precision Medicine (TOPMed) program, and Alzheimer’s Disease Sequencing Project (ADSP). These studies have identified hundreds of genetic loci associated with atrial fibrillation, heart failure, hypertension, and Alzheimer’s disease.

2. Integration of multi-omics data to understand disease molecular mechanisms. Complex diseases are usually caused by the interplay of genetic and environmental factors. We have identified numerous molecular signatures from gene expression, protein expression, and DNA methylation that are related to aging and cardiovascular disease. We are also developing computational methods to integrate different molecular signatures and build gene interaction networks to study potential disease regulation networks.

3. Development of machine learning models for early disease diagnosis. We have built multiple machine learning models to predict dementia risk from midlife risk factors and neuropsychological tests. In combination with neuroimaging and blood-based measures, we are also developing multimodal machine learning methods to identify new biomarkers that are predictive of future cognitive impairment.

4. Exploration of digital and wearable devices for health monitoring. We have deployed thousands of wearable devices and mobile apps to monitor cardiovascular health and cognitive health. We are integrating active engagement with passive engagement technologies from the habitual environment to make sustained monitoring feasible. Novel analytic strategies are also being developed to analyze big unstructured data to identify potential digital biomarkers that are predictive of future health outcomes.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Investigator, Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University

Education

  • National University of Singapore (NUS), PhD
  • Peking University, BA
  • Peking University, BS

Publications

  • Published on 5/23/2024

    Frederiksen TC, Benjamin EJ, Trinquart L, Lin H, Dahm CC, Christiansen MK, Jensen HK, Preis SR, Kornej J. Bidirectional Association Between Atrial Fibrillation and Myocardial Infarction, and Relation to Mortality in the Framingham Heart Study. J Am Heart Assoc. 2024 Jun 04; 13(11):e032226. PMID: 38780172.

    Read at: PubMed
  • Published on 5/15/2024

    Herbert C, Manabe YC, Filippaios A, Lin H, Wang B, Achenbach C, Kheterpal V, Hartin P, Suvarna T, Harman E, Stamegna P, Rao LV, Hafer N, Broach J, Luzuriaga K, Fitzgerald KA, McManus DD, Soni A. Differential Viral Dynamics by Sex and Body Mass Index During Acute SARS-CoV-2 Infection: Results From a Longitudinal Cohort Study. Clin Infect Dis. 2024 May 15; 78(5):1185-1193. PMID: 37972270.

    Read at: PubMed
  • Published on 5/15/2024

    Jiang MZ, Gaynor SM, Li X, Van Buren E, Stilp A, Buth E, Wang FF, Manansala R, Gogarten SM, Li Z, Polfus LM, Salimi S, Bis JC, Pankratz N, Yanek LR, Durda P, Tracy RP, Rich SS, Rotter JI, Mitchell BD, Lewis JP, Psaty BM, Pratte KA, Silverman EK, Kaplan RC, Avery C, North KE, Mathias RA, Faraday N, Lin H, Wang B, Carson AP, Norwood AF, Gibbs RA, Kooperberg C, Lundin J, Peters U, Dupuis J, Hou L, Fornage M, Benjamin EJ, Reiner AP, Bowler RP, Lin X, Auer PL, Raffield LM. Whole genome sequencing based analysis of inflammation biomarkers in the Trans-Omics for Precision Medicine (TOPMed) consortium. Hum Mol Genet. 2024 May 15. PMID: 38747556.

    Read at: PubMed
  • Published on 3/21/2024

    Ding H, Wang B, Hamel AP, Karjadi C, Ang TFA, Au R, Lin H. Exploring cognitive progression subtypes in the Framingham Heart Study. Alzheimers Dement (Amst). 2024; 16(1):e12574. PMID: 38515438.

    Read at: PubMed
  • Published on 3/21/2024

    Wang Y, Sarnowski C, Lin H, Pitsillides AN, Heard-Costa NL, Choi SH, Wang D, Bis JC, Blue EE, Boerwinkle E, De Jager PL, Fornage M, Wijsman EM, Seshadri S, Dupuis J, Peloso GM, DeStefano AL. Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data. Alzheimers Dement. 2024 May; 20(5):3290-3304. PMID: 38511601.

    Read at: PubMed
  • Published on 2/15/2024

    Ding H, Kim M, Searls E, Sunderaraman P, De Anda-Duran I, Low S, Popp Z, Hwang PH, Li Z, Goyal K, Hathaway L, Monteverde J, Rahman S, Igwe A, Kolachalama VB, Au R, Lin H. Digital neuropsychological measures by defense automated neurocognitive assessment: reference values and clinical correlates. Front Neurol. 2024; 15:1340710. PMID: 38426173.

    Read at: PubMed
  • Published on 1/23/2024

    Leung YY, Naj AC, Chou YF, Valladares O, Schmidt M, Hamilton-Nelson K, Wheeler N, Lin H, Gangadharan P, Qu L, Clark K, Kuzma AB, Lee WP, Cantwell L, Nicaretta H, Haines J, Farrer L, Seshadri S, Brkanac Z, Cruchaga C, Pericak-Vance M, Mayeux RP, Bush WS, Destefano A, Martin E, Schellenberg GD, Wang LS. Human whole-exome genotype data for Alzheimer's disease. Nat Commun. 2024 Jan 23; 15(1):684. PMID: 38263370.

    Read at: PubMed
  • Published on 1/16/2024

    Sunderaraman P, De Anda-Duran I, Karjadi C, Peterson J, Ding H, Devine SA, Shih LC, Popp Z, Low S, Hwang PH, Goyal K, Hathaway L, Monteverde J, Lin H, Kolachalama VB, Au R. Design and Feasibility Analysis of a Smartphone-Based Digital Cognitive Assessment Study in the Framingham Heart Study. J Am Heart Assoc. 2024 Jan 16; 13(2):e031348. PMID: 38226510.

    Read at: PubMed
  • Published on 1/16/2024

    Popp Z, Low S, Igwe A, Rahman MS, Kim M, Khan R, Oh E, Kumar A, De Anda-Duran I, Ding H, Hwang PH, Sunderaraman P, Shih LC, Lin H, Kolachalama VB, Au R. Shifting From Active to Passive Monitoring of Alzheimer Disease: The State of the Research. J Am Heart Assoc. 2024 Jan 16; 13(2):e031247. PMID: 38226518.

    Read at: PubMed
  • Published on 1/16/2024

    De Anda-Duran I, Sunderaraman P, Searls E, Moukaled S, Jin X, Popp Z, Karjadi C, Hwang PH, Ding H, Devine S, Shih LC, Low S, Lin H, Kolachalama VB, Bazzano L, Libon DJ, Au R. Comparing Cognitive Tests and Smartphone-Based Assessment in 2 US Community-Based Cohorts. J Am Heart Assoc. 2024 Jan 16; 13(2):e032733. PMID: 38226519.

    Read at: PubMed

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