Hiroshi Mashimo, MD, PhD

Adjunct Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Hiroshi Mashimo is currently Chief of Gastroenterology at the VA Boston Healthcare System, Assistant Professor of Medicine at Harvard Medical School and Adjunct Assistant Professor Of Medicine at Chobanian and Avedisian School of Medicine. He obtained his A.B. at Harvard College and his M.S., M.D. and Ph.D. degrees at Albert Einstein College of Medicine. He completed his medical internship, residency, and gastroenterology fellowship at Massachusetts General Hospital. His interest in molecular physiology led to advanced research and clinical training at Harvard Medical School, with Dr Daniel K. Podolsky and Dr Mark C. Fishman at Massachusetts General Hospital, and with Dr Raj K. Goyal at Beth Israel Hospital. His pioneering work using genetically altered mice models to understand basic gastrointestinal physiology has led to important understandings of the distinct roles of various mediators such as nitric oxide synthases and vasoactive intestinal peptides in the field of gastrointestinal motility. He has continued his interest in clinical gastrointestinal motility as Director of the Swallowing and Motility Disorders services at the VA Boston Healthcare, and is involved with training and teaching of students, residents and fellows at Brigham and Women's Hospital, the VA Boston Healthcare, and Harvard Medical School. He has published numerous original and review articles in various medical and scientific journals.

Publications

  • Published 10/31/2025

    Huang K, Mashimo H. Retroflexion in the Stomach During Endoscopy: Importance of the Examination and Its Utility. Ann N Y Acad Sci. 2025 Dec; 1554(1):343-352. PMID: 41170845.

    Read at: PubMed

  • Published 9/25/2025

    Goldman A, Gonzalez G, Karpova SA, Buon L, Shammas MA, Mashimo H, Frank MH, Frank NY. Optimal Cannabinoid-Terpene Combination Ratios Suppress Mutagenicity of Gastric Reflux in Normal and Metaplastic Esophageal Cells. bioRxiv. 2025 Sep 25. PMID: 41040236.

    Read at: PubMed

  • Published 7/7/2025

    Bellavance D, Chua S, Mashimo H. Gastrointestinal Motility Effects of GLP-1 Receptor Agonists. Curr Gastroenterol Rep. 2025 Jul 07; 27(1):49. PMID: 40622491.

    Read at: PubMed

  • Published 7/20/2023

    Triadafilopoulos G, Mashimo H, Tatum R, O'Clarke J, Hawn M. Mixed Esophageal Disease (MED): A New Concept. Dig Dis Sci. 2023 Sep; 68(9):3542-3554. PMID: 37470896.

    Read at: PubMed

  • Published 5/12/2023

    Kumar S, Zhao J, Talluri S, Buon L, Mu S, Potluri LB, Liao C, Shi J, Chakraborty C, Gonzalez GB, Tai YT, Patel J, Pal J, Mashimo H, Samur MK, Munshi NC, Shammas MA. Elevated APE1 Dysregulates Homologous Recombination and Cell Cycle Driving Genomic Evolution, Tumorigenesis, and Chemoresistance in Esophageal Adenocarcinoma. Gastroenterology. 2023 Aug; 165(2):357-373. PMID: 37178737.

    Read at: PubMed

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Websites

Education

  • Albert Einstein College of Medicine, MD
  • Albert Einstein College of Medicine, PhD
  • Yeshiva University, MS
  • Harvard College, AB

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