George J. Murphy, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:

1.) Science at the intersection of regenerative medicine and aging
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Understanding the molecular and functional basis of exceptional longevity: Dissecting resistance to aging-related disease
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’
5.) Developmental hematopoiesis

Publications

  • Published 10/4/2026

    Skvir NJ, Dowrey TW, Cranston SF, MacDonald E, Giadone R, Jones D, Golden CS, Pate B, Labott M, Serrano MA, Alysandratos KD, Vanuytsel K, Murphy GJ. Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues. bioRxiv. 2026 Oct 04. PMID: 42856619.

    Read at: PubMed

  • Published 10/1/2026

    Alsolami S, Wang M, Sabedot TS, Singh U, Kirk B, Mitchell L, Hernandez M, Skvir N, Bowman C, Oiwa K, Agarwal R, Mahmoudi M, Cuoco MS, MacDonald E, Cranston S, Lucciola R, Boassa D, Herdy JR, Jones JR, Yoshikiyo K, Mertens J, Martinez-Trujillo J, Jaremko L, Murphy GJ, Gage FH. An age-preserving neuronal iSpheroid platform for modeling human aging and Alzheimer's disease. bioRxiv. 2026 Oct 01. PMID: 42856336.

    Read at: PubMed

  • Published 7/1/2026

    Skvir NJ, Ysasi AB, Jarzabek V, Yeung AK, Chen JG, Dries R, Murphy GJ. High resolution spatial profiling of the hematopoietic landscape of the murine lung. iScience. 2026 Jul 17; 29(7):116595. PMID: 42491594.

    Read at: PubMed

  • Published 5/26/2026

    Lu S, Karkempetzaki AI, Huang N, Zhang C, Murphy GJ, Ravid K. Hematopoietic JAK2V617F mutation-induced reprogramming of blood and bone marrow megakaryocytes. Blood Adv. 2026 May 26; 10(10):3437-3441. PMID: 41707101.

    Read at: PubMed

  • Published 5/21/2026

    Pate B, Goldstein A, Labott M, Lizarralde-Iragorri M, Chankhunthod A, Tyson T, Sloan M, Wijeyesekera C, Wilks A, Steinberg MH, Murphy GJ, Vanuytsel K. Modeling Genetic Diversity in Sickle Cell Disease Reveals Heterogeneous Responses to HbF-Inducing Therapies. bioRxiv. 2026 May 21. PMID: 42239194.

    Read at: PubMed

View All 76 Publications:   View Full Profile in BUMC

Other Positions

  • Member, Pulmonary Center
    Boston University
  • Co-Director, Center for Regenerative Medicine
    Boston University
  • Member, Center for Excellence in Sickle Cell Disease
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
  • Member, Genome Science Institute
    Boston University

Websites

Education

  • University of Oxford, PhD
  • Trinity College, BS

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