George J. Murphy, PhD
Associate Professor, Medicine
Biography
I have developed an approach to science that utilizes multiple stem cell-based platforms to answer basic biological questions and combat human disease. My current research portfolio is a direct reflection of my evolution as a scientist in which my early studies of hematopoietic development led to the generation of useful tools and reagents as well as methodologies and insights that synergized into a potent platform in the emerging and rapidly expanding field of pluripotent stem cell biology. My group is composed of dynamic and passionate young researchers and together we have impacted the following areas of investigation:
1.) Science at the intersection of regenerative medicine and aging
2.) The generation, culture, and directed differentiation of pluripotent stem cells
3.) Understanding the molecular and functional basis of exceptional longevity: Dissecting resistance to aging-related disease
4.) Pluripotent Stem Cell Modeling of Human Disease: The ‘Clinical Trial in a Test Tube’
5.) Developmental hematopoiesis
Other Positions
- Member, Pulmonary Center, Boston University
- Co-Director, Center for Regenerative Medicine, Boston University
- Member, Center for Excellence in Sickle Cell Disease, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Boston Medical Center
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Member, Genome Science Institute, Boston University
Education
- University of Oxford, PhD
- Trinity College, BS
Publications
- Published on 11/15/2024
Yeung AK, Murphy GJ. The lung is a megakaryocyte outpost that can defend against thrombocytopenic attack. J Clin Invest. 2024 Nov 15; 134(22). PMID: 39545421.
Read at: PubMed - Published on 9/25/2024
Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Milman S, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. Aging Cell. 2024 Sep 25; e14351. PMID: 39319670.
Read at: PubMed - Published on 6/4/2024
Ysasi AB, Engler AE, Bawa PS, Wang F, Conrad RD, Yeung AK, Rock JR, Beane-Ebel J, Mazzilli SA, Franklin RA, Mizgerd JP, Murphy GJ. A specialized population of monocyte-derived tracheal macrophages promote airway epithelial regeneration through a CCR2-dependent mechanism. iScience. 2024 Jul 19; 27(7):110169. PMID: 38993668.
Read at: PubMed - Published on 5/7/2024
Kretov DA, Folkes L, Mora-Martin A, Walawalkar IA, Imrat, Syedah N, Vanuytsel K, Moxon S, Murphy GJ, Cifuentes D. The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. Nat Commun. 2024 May 07; 15(1):3821. PMID: 38714702.
Read at: PubMed - Published on 3/16/2024
Edwards CV, Ferri GM, Villegas-Galaviz J, Ghosh S, Bawa PS, Wang F, Klimtchuk E, Ajayi TB, Morgan GJ, Prokaeva T, Staron A, Ruberg FL, Sanchorawala V, Giadone RM, Murphy GJ. Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition. bioRxiv. 2024 Mar 16. PMID: 38558967.
Read at: PubMed - Published on 3/14/2024
Dowrey TW, Cranston SF, Skvir N, Lok Y, Gould B, Petrowitz B, Villar D, Shan J, James M, Dodge M, Belkina AC, Giadone RM, Sebastiani P, Perls TT, Andersen SL, Murphy GJ. A longevity-specific bank of induced pluripotent stem cells from centenarians and their offspring. bioRxiv. 2024 Mar 14. PMID: 38559230.
Read at: PubMed - Published on 11/28/2023
Yeung AK, Villacorta-Martin C, Lindstrom-Vautrin J, Belkina AC, Vanuytsel K, Dowrey TW, Ysasi AB, Bawa P, Wang F, Vrbanac V, Mostoslavsky G, Balazs AB, Murphy GJ. De novo hematopoiesis from the fetal lung. Blood Adv. 2023 Nov 28; 7(22):6898-6912. PMID: 37729429.
Read at: PubMed - Published on 9/27/2023
Hoffman SE, Dowrey TW, Villacorta Martin C, Bi K, Titchen B, Johri S, DelloStritto L, Patel M, Mackichan C, Inga S, Chen J, Grimaldi G, Napolitano S, Wakiro I, Wu J, Yeung J, Rotem A, Sicinska E, Shannon E, Clancy T, Wang J, Denning S, Brais L, Besson NR, Pfaff KL, Huang Y, Kao KZ, Rodig S, Hornick JL, Vigneau S, Park J, Kulke MH, Chan J, Van Allen EM, Murphy GJ. Intertumoral lineage diversity and immunosuppressive transcriptional programs in well-differentiated gastroenteropancreatic neuroendocrine tumors. Sci Adv. 2023 Sep 29; 9(39):eadd9668. PMID: 37756410.
Read at: PubMed - Published on 7/19/2023
Kretov DA, Folkes L, Mora-Martin A, Syedah N, Walawalkar IA, Vanyustel K, Moxon S, Murphy GJ, Cifuentes D. The miR-144/Hmgn2 regulatory axis orchestrates chromatin organization during erythropoiesis. bioRxiv. 2023 Jul 19. PMID: 37503141.
Read at: PubMed - Published on 7/13/2023
Ghosh S, Villacorta-Martin C, Lindstrom-Vautrin J, Kenney D, Golden CS, Edwards CV, Sanchorawala V, Connors LH, Giadone RM, Murphy GJ. Mapping cellular response to destabilized transthyretin reveals cell- and amyloidogenic protein-specific signatures. Amyloid. 2023 Dec; 30(4):379-393. PMID: 37439769.
Read at: PubMed
View 51 more publications: View full profile at BUMC