Florian Douam, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Florian Douam, Ph.D. is an Assistant Professor of Microbiology at Boston University Chobanian and Avedisian School of Medicine and a core investigator at the National Emerging Infectious Diseases Laboratories (NEIDL). Dr. Douam has a PhD in molecular virology and more than a decade of experience investigating virus biology in cell culture and animal models. Specifically, Dr. Douam is a viral immunologist with deep expertise in generating and using innovative mouse models to investigate viral pathogenesis and immune responses to viruses in BSL-2 and BSL-3 laboratories. At the NEIDL, he leads a research team focused on identifying the molecular and cellular mechanisms shaping immune outcomes in human RNA virus infections, employing a variety of viral pathogens from mosquito-borne viruses to coronaviruses.

Publications

  • Published 1/5/2026

    Subramaniam S, Napoleon MA, Lotfollahzadeh S, Kamal MH, Kurniawan H, Francis C, Elsadawi M, Wu Wong DJ, Kenney D, Douam F, Bosmann M, Whelan SA, Cabral H, Burks EJ, Zhao G, Kolachalama VB, Ravid K, Chitalia VC. Tryptophan metabolism reprogramming potentially contributes to the prothrombotic milieu in mice and humans with SARS-CoV-2. Blood Vessel Thromb Hemost. 2026 Feb; 3(1):100128. PMID: 41743170.

    Read at: PubMed

  • Published 9/29/2025

    Unali G, Douam F. Orthoflavivirus Vaccine Platforms: Current Strategies and Challenges. Vaccines (Basel). 2025 Sep 29; 13(10). PMID: 41150403.

    Read at: PubMed

  • Published 9/8/2025

    Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Immune signatures of SARS-CoV-2 infection resolution in human lung tissues. PLoS Pathog. 2025 Sep; 21(9):e1013469. PMID: 40920821.

    Read at: PubMed

  • Published 9/7/2025

    Kenney D, Matsuo M, Unali G, Wacquiez A, Saeed M, Douam F. Comprehensive Analysis of the Impact of Weight Loss Thresholds on Mouse Models of Fatal Viral Infection. Viruses. 2025 Sep 07; 17(9). PMID: 41012653.

    Read at: PubMed

  • Published 7/8/2025

    Zhang J, Chavez EC, Winkler M, Liu J, Carver S, Lin AE, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O' Connell AK, Matsuo M, Norton JE, Kenney D, Adamson B, Kleiner RE, Burwitz B, Crossland NA, Douam F, Ploss A. Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine. Nat Microbiol. 2025 Aug; 10(8):1902-1917. PMID: 40629111.

    Read at: PubMed

View All 55 Publications:   View Full Profile in BUMC

Other Positions

  • Faculty, National Emerging Infectious Disease Lab
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • L'École Normale Supérieure de Lyon, PhD
  • Universite De Tours, BS

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