Florian Douam, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Florian Douam, Ph.D. is an Assistant Professor of Microbiology at Boston University Chobanian and Avedisian School of Medicine and a core investigator at the National Emerging Infectious Diseases Laboratories (NEIDL). Dr. Douam has a PhD in molecular virology and more than a decade of experience investigating virus biology in cell culture and animal models. Specifically, Dr. Douam is a viral immunologist with deep expertise in generating and using innovative mouse models to investigate viral pathogenesis and immune responses to viruses in BSL-2 and BSL-3 laboratories. At the NEIDL, he leads a research team focused on identifying the molecular and cellular mechanisms shaping immune outcomes in human RNA virus infections, employing a variety of viral pathogens from mosquito-borne viruses to coronaviruses.

Publications

  • Published 10/8/2026

    Kenney D, Matsuo M, Pantelias A, Leger J, Kaplan A, Cerbo F, Chen DY, Adams S, Unali G, Wallace D, Saeed M, Belkina A, Harly C, Douam F. Male and female mice achieve equivalent protection against heterologous SARS-CoV-2 infection through divergent immune mechanisms. bioRxiv. 2026 Oct 08. PMID: 42856521.

    Read at: PubMed

  • Published 8/1/2026

    Shastry A, Hiller BE, Sanders NL, Tseng AE, Kothari J, O'Connell AK, Gertje HP, Ha CT, Murzin E, Traber KE, Lederer JA, Jones MR, Douam F, Beach TG, Remick DG, Crossland NA, Monti S, Campbell JD, Mizgerd JP. Subphenotypes of pneumonia defined by pulmonary histopathological features. Am J Respir Crit Care Med. 2026 Aug 01; 212(8):1778-1792. PMID: 42089675.

    Read at: PubMed

  • Published 7/10/2026

    Sanders NL, Kenney D, Etesami NS, Shenoy AT, Kontodimas K, Amirault J, Okolo C, Dominguez VA, Semaan M, Murzin E, Lederer JA, Douam F, Saeed M, Mizgerd JP. Systemic and lung-resident memory elicited by OC43 coronavirus infection in mice. J Immunol. 2026 Jul 10; 215(7). PMID: 42455848.

    Read at: PubMed

  • Published 6/3/2026

    Soto Albrecht YE, Morrow RM, Kenney D, Olali AZ, Wacquiez A, Chehadeh N, Cen Z, Haltom JA, Chen I, Ranshing SS, Widjaja GA, Angelin A, Tintos-Hernandez JA, Xie W, Potluri P, Lott MT, Zhang S, Saeed M, Murdock DG, Weiss SR, Douam F, Wallace DC. Mitochondrial OXPHOS restricts SARS-CoV-2 replication. Sci Adv. 2026 Jun 05; 12(23):eadz3081. PMID: 42234733.

    Read at: PubMed

  • Published 4/14/2026

    Streicher F, Kenney D, Caval V, Chazal M, Aicher S-M, Gracias S, Adams S, Matsuo M, Roesch F, Douam F, Jouvenet N. Type I and III interferon responses restrict infection by tick-borne orthoflaviviruses through IFI6. J Virol. 2026 May 19; 100(5):e0076025. PMID: 41979927.

    Read at: PubMed

View All 60 Publications:   View Full Profile in BUMC

Other Positions

  • Faculty, National Emerging Infectious Disease Lab
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • L'École Normale Supérieure de Lyon, PhD
  • Universite De Tours, BS

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