Florian Douam, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Florian Douam, Ph.D. is an Assistant Professor of Microbiology at Boston University Chobanian and Avedisian School of Medicine and a core investigator at the National Emerging Infectious Diseases Laboratories (NEIDL). Dr. Douam has a PhD in molecular virology and more than a decade of experience investigating virus biology in cell culture and animal models. Specifically, Dr. Douam is a viral immunologist with deep expertise in generating and using innovative mouse models to investigate viral pathogenesis and immune responses to viruses in BSL-2 and BSL-3 laboratories. At the NEIDL, he leads a research team focused on identifying the molecular and cellular mechanisms shaping immune outcomes in human RNA virus infections, employing a variety of viral pathogens from mosquito-borne viruses to coronaviruses.

Publications

  • Published 9/8/2025

    Kenney D, O'Connell AK, Tseng AE, Turcinovic J, Sheehan ML, Nitido AD, Montanaro P, Gertje HP, Ericsson M, Connor JH, Vrbanac V, Crossland NA, Harly C, Balazs AB, Douam F. Immune signatures of SARS-CoV-2 infection resolution in human lung tissues. PLoS Pathog. 2025 Sep; 21(9):e1013469. PMID: 40920821.

    Read at: PubMed

  • Published 7/8/2025

    Zhang J, Chavez EC, Winkler M, Liu J, Carver S, Lin AE, Biswas A, Tamura T, Tseng A, Wang D, Benhamou A, O' Connell AK, Matsuo M, Norton JE, Kenney D, Adamson B, Kleiner RE, Burwitz B, Crossland NA, Douam F, Ploss A. Amino acid changes in two viral proteins drive attenuation of the yellow fever 17D vaccine. Nat Microbiol. 2025 Aug; 10(8):1902-1917. PMID: 40629111.

    Read at: PubMed

  • Published 6/12/2025

    Caobi A, Su CM, Beusch CM, Kenney D, Darling TL, Feng S, Semaan M, Wacquiez A, Sanders NL, Tully ES, Chen DY, Evdokimova M, Ding Z, Jones D, Alysandratos KD, Mizgerd JP, Kirchdoerfer RN, Kotton DN, Douam F, Crossland NA, Boon ACM, Gordon DE, Baker SC, Saeed M. SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses. Proc Natl Acad Sci U S A. 2025 Jun 17; 122(24):e2426528122. PMID: 40504150.

    Read at: PubMed

  • Published 4/29/2025

    Mcconney CS, Kenney D, Ennis CS, Smith-Mahoney EL, Ayuso MJ, Zhong J, Douam F, Sagar M, Snyder-Cappione JE. Individuals Infected with SARS-CoV-2 Prior to COVID-19 Vaccination Maintain Vaccine-Induced RBD-Specific Antibody Levels and Viral Neutralization Activity for One Year. Viruses. 2025 Apr 29; 17(5). PMID: 40431652.

    Read at: PubMed

  • Published 2/4/2025

    Subramaniam S, Jose A, Kenney D, O'Connell AK, Bosmann M, Douam F, Crossland N. Challenging the notion of endothelial infection by SARS-CoV-2: insights from the current scientific evidence. Front Immunol. 2025; 16:1443932. PMID: 39967675.

    Read at: PubMed

View All 51 Publications:   View Full Profile in BUMC

Other Positions

  • Faculty, National Emerging Infectious Disease Lab
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • L'École Normale Supérieure de Lyon, PhD
  • Universite De Tours, BS

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