Erica D. Pratt is an assistant professor of Biomedical Engineering at Boston University. Dr. Pratt earned her B.S. in Mechanical Engineering and Biomedical Engineering from Carnegie Mellon University. She went on to earn her Ph.D. in Biomedical Engineering at Cornell University working with Brian J. Kirby. There she co-designed the Geometrically Enhanced Differential Immunocapture (GEDI) platform for high-efficiency and high-purity microfluidic isolation of circulating tumor cells from whole blood samples. She then completed multi-disciplinary postdocs with Andrew D. Rhim and Laurie L. Parker developing assays for non-invasive omic characterization of solid cancers. Her lab works at the interface of engineering, chemical biology and oncology to develop assays for cancer diagnosis and monitoring.
Dr. Pratt has been recognized with several awards including a post-doctoral NIH Ruth L. Krischstein National Research Service Award and Momental Foundation Unfettered Research Grant.
- Assistant Professor, Hematology & Medical Oncology, Medicine, Boston University Chobanian & Avedisian School of Medicine
- Cornell University, PhD
- Published on 6/2/2022
Widstrom NE, Perez M, Pratt ED, Heier JL, Blankenhorn JF, Breidenbach L, Peterson H, Parker LL. Novel Bruton's Tyrosine Kinase (BTK) Substrates for Time-Resolved Luminescence Assays. ACS Chem Biol. 2022 Jun 17; 17(6):1328-1333. PMID: 35653784.
- Published on 11/18/2021
Cowan RW, Pratt ED, Kang JM, Zhao J, Wilhelm JJ, Abdulla M, Qiao EM, Brennan LP, Ulintz PJ, Bellin MD, Rhim AD. Pancreatic Cancer-Related Mutational Burden Is Not Increased in a Patient Cohort With Clinically Severe Chronic Pancreatitis. Clin Transl Gastroenterol. 2021 11 18; 12(11):e00431. PMID: 34797250.
- Published on 3/29/2021
Pratt ED, ZHen DB, Cowan RW, Cameron H, Schradle K, Manning SL, Gunchick V, Simeone DM, Sahai V, Rhim AD. Ultra-low Input Circulating Tumor DNA Detection by MED-Amp in Early-Stage Pancreatic Cancer. 2021.
- Published on 10/9/2020
Jena S, Damayanti NP, Tan J, Pratt ED, Irudayaraj JMK, Parker LL. Multiplexable fluorescence lifetime imaging (FLIM) probes for Abl and Src-family kinases. Chem Commun (Camb). 2020 Nov 11; 56(87):13409-13412. PMID: 33035286.
- Published on 5/24/2019
Pratt ED, Cowan RW, Manning SL, Qiao E, Cameron H, Schradle K, Simeone DM, Zhen DB. Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification. Anal Chem. 2019 06 18; 91(12):7516-7523. PMID: 31072097.
- Published on 11/23/2017
Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC. MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nat Commun. 2017 11 23; 8(1):1728. PMID: 29170413.
- Published on 6/20/2017
Antonarakis ES, Tagawa ST, Galletti G, Worroll D, Ballman K, Vanhuyse M, Sonpavde G, North S, Albany C, Tsao CK, Stewart J, Zaher A, Szatrowski T, Zhou W, Gjyrezi A, Tasaki S, Portella L, Bai Y, Lannin TB, Suri S, Gruber CN, Pratt ED, Kirby BJ, Eisenberger MA, Nanus DM, Saad F, Giannakakou P. Randomized, Noncomparative, Phase II Trial of Early Switch From Docetaxel to Cabazitaxel or Vice Versa, With Integrated Biomarker Analysis, in Men With Chemotherapy-Naïve, Metastatic, Castration-Resistant Prostate Cancer. J Clin Oncol. 2017 Oct 01; 35(28):3181-3188. PMID: 28632486.
- Published on 11/4/2014
Pratt ED, Stepansky A, Hicks J, Kirby BJ. Single-cell copy number analysis of prostate cancer cells captured with geometrically enhanced differential immunocapture microdevices. Anal Chem. 2014 Nov 18; 86(22):11013-7. PMID: 25363873.
- Published on 8/3/2012
Ruder WC, Pratt ED, Brandy NZ, LaVan DA, LeDuc PR, Antaki JF. Calcium signaling is gated by a mechanical threshold in three-dimensional environments. Sci Rep. 2012; 2:554. PMID: 22870383.
- Published on 4/27/2012
Kirby BJ, Jodari M, Loftus MS, Gakhar G, Pratt ED, Chanel-Vos C, Gleghorn JP, Santana SM, Liu H, Smith JP, Navarro VN, Tagawa ST, Bander NH, Nanus DM, Giannakakou P. Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device. PLoS One. 2012; 7(4):e35976. PMID: 22558290.
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