Elliott Hagedorn, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Elliott J. Hagedorn is a cell and developmental biologist with expertise in hematopoiesis, stem cell biology and vascular heterogeneity. Research in the Hagedorn Lab utilizes a combination of genetics, genomics and advanced live cell imaging in zebrafish to understand how blood and cancer cells migrate into and out of distinct tissues and organs. The goal of this work is to elucidate novel molecular mechanisms that can be therapeutically targeted to regulate cell migration in a tissue-specific fashion - to inhibit it in certain contexts (e.g., inflammatory diseases and cancer metastasis) and promote it in others (e.g., stem cell transplantation and cell-based therapies). Dr. Hagedorn received his PhD from Duke University for his work on basement membrane transmigration in the laboratory of Dr. David Sherwood. He completed postdoctoral training with Dr. Leonard Zon at Boston Children’s Hospital/Harvard Medical School. Dr. Hagedorn has taught in courses at Purdue, Duke, Harvard and in the Embryology Course at the MBL in Woods Hole, MA; his research has been funded by grants from the National Institutes of Health, Howard Hughes Medical Institute and the Helen Hay Whitney Foundation.

Publications

  • Published 5/18/2023

    Binder V, Li W, Faisal M, Oyman K, Calkins DL, Shaffer J, Teets EM, Sher S, Magnotte A, Belardo A, Deruelle W, Gregory TC, Orwick S, Hagedorn EJ, Perlin JR, Avagyan S, Lichtig A, Barrett F, Ammerman M, Yang S, Zhou Y, Carson WE, Shive HR, Blachly JS, Lapalombella R, Zon LI, Blaser BW. Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C. Cell Rep. 2023 May 30; 42(5):112528. PMID: 37209097.

    Read at: PubMed

  • Published 4/28/2023

    Hagedorn EJ, Perlin JR, Freeman RJ, Wattrus SJ, Han T, Mao C, Kim JW, Fernández-Maestre I, Daily ML, D'Amato C, Fairchild MJ, Riquelme R, Li B, Ragoonanan DAVE, Enkhbayar K, Henault EL, Wang HG, Redfield SE, Collins SH, Lichtig A, Yang S, Zhou Y, Kunar B, Gomez-Salinero JM, Dinh TT, Pan J, Holler K, Feldman HA, Butcher EC, van Oudenaarden A, Rafii S, Junker JP, Zon LI. Transcription factor induction of vascular blood stem cell niches in vivo. Dev Cell. 2023 Jun 19; 58(12):1037-1051.e4. PMID: 37119815.

    Read at: PubMed

  • Published 9/22/2022

    Wattrus SJ, Smith ML, Rodrigues CP, Hagedorn EJ, Kim JW, Budnik B, Zon LI. Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality. Science. 2022 Sep 23; 377(6613):1413-1419. PMID: 36137040.

    Read at: PubMed

  • Published 5/14/2021

    Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1? drives erythropoiesis. Science. 2021 05 14; 372(6543):716-721. PMID: 33986176.

    Read at: PubMed

  • Published 9/10/2019

    Morad G, Carman CV, Hagedorn EJ, Perlin JR, Zon LI, Mustafaoglu N, Park TE, Ingber DE, Daisy CC, Moses MA. Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis. ACS Nano. 2019 12 24; 13(12):13853-13865. PMID: 31479239.

    Read at: PubMed

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Websites

Education

  • Duke University, PhD
  • Purdue University, BS

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