Dennis Jones, PhD is an Assistant Professor of Pathology & Laboratory Medicine at the Chobanian and Avedisian School of Medicine.Our research focuses on understanding how tumors impact the functionality of blood vessels, which are essential for immune cells, such as T cells, to infiltrate tumors. Our previous studies have found that tumors can cause the compression and dysfunction of blood vessels, which ultimately limits T cell entry into the tumor. Therefore, our lab aims to develop approaches to improve vascular function within tumors, with the goal of increasing T cell entry. In combination, we will use immunotherapy to enhance the killing ability of T cells. Currently, we are testing this combination therapy in preclinical models. Our ultimate goal is to improve outcomes for patients with metastatic breast cancer.
Our lab is comprised of a multidisciplinary team of trainees with expertise in cancer biology, immunology, and vascular biology. We employ a range of techniques, including in vitro and in vivo experiments, imaging, and molecular and cellular biology assays, to better understand the complex mechanisms underlying tumor-induced vascular dysfunction and immune suppression.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
- Member, BU-BMC Cancer Center, Boston University
- Yale University School of Medicine, PhD
- Morehouse College, BS
- Published on 11/19/2023
Lei PJ, Ruscic KJ, Roh K, Rajotte JJ, O'Melia MJ, Bouta EM, Marquez M, Pereira ER, Kumar AS, Arroyo-Ataz G, Razavi MS, Zhou H, Menzel L, Kumra H, Duquette M, Huang P, Baish JW, Munn LL, Ubellacker JM, Jones D, Padera TP. Lymphatic muscle cells are unique cells that undergo aging induced changes. bioRxiv. 2023 Nov 19. PMID: 38014141.
- Published on 10/18/2023
Delclaux I, Ventre KS, Jones D, Lund AW. The tumor-draining lymph node as a reservoir for systemic immune surveillance. Trends Cancer. 2023 Oct 18. PMID: 37863720.
- Published on 6/21/2023
Lei PJ, Pereira ER, Andersson P, Amoozgar Z, Van Wijnbergen JW, O'Melia MJ, Zhou H, Chatterjee S, Ho WW, Posada JM, Kumar AS, Morita S, Menzel L, Chung C, Ergin I, Jones D, Huang P, Beyaz S, Padera TP. Cancer cell plasticity and MHC-II-mediated immune tolerance promote breast cancer metastasis to lymph nodes. J Exp Med. 2023 Sep 04; 220(9). PMID: 37341991.
- Published on 6/6/2023
Jana S, Li W, Lei PJ, Wang Z, Huang P, Jones D. "Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance". bioRxiv. 2023 Jun 06. PMID: 37333242.
- Published on 10/31/2022
Arroyo-Ataz G, Jones D. Dissection of murine collecting lymphatic vessels for imaging, single-cell analysis, and tissue culture of lymphatic muscle cells. STAR Protoc. 2022 Dec 16; 3(4):101800. PMID: 36353362.
- Published on 7/19/2021
Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP. Solid stress impairs lymphocyte infiltration into lymph-node metastases. Nat Biomed Eng. 2021 12; 5(12):1426-1436. PMID: 34282290.
- Published on 5/24/2021
Jana S, Muscarella RA, Jones D. The Multifaceted Effects of Breast Cancer on Tumor-Draining Lymph Nodes. Am J Pathol. 2021 08; 191(8):1353-1363. PMID: 34043978.
- Published on 3/23/2021
Saeboe AM, Nikiforov AY, Toufanian R, Kays JC, Chern M, Casas JP, Han K, Piryatinski A, Jones D, Dennis AM. Extending the Near-Infrared Emission Range of Indium Phosphide Quantum Dots for Multiplexed In Vivo Imaging. Nano Lett. 2021 04 14; 21(7):3271-3279. PMID: 33755481.
- Published on 9/11/2020
Gustine JN, Jones D. Immunopathology of Hyperinflammation in COVID-19. Am J Pathol. 2021 01; 191(1):4-17. PMID: 32919977.
- Published on 3/20/2020
Jones D. Parallels of Resistance between Angiogenesis and Lymphangiogenesis Inhibition in Cancer Therapy. Cells. 2020 03 20; 9(3). PMID: 32244922.
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