David Hing-Kwei Chui, MD

Emeritus Professor, Medicine

David Chui


Dr. Chui is a physician-scientist with a long standing clinical and research interest in hemoglobin disorders. He has contributed to the field ranging from population genetics, genotype-phenotype correlation, genetic modifiers, and regulation of HbF expression. He received MD,CM degree from McGill University, Montreal, Canada in 1963. In 1970, he joined the Faculty at the McMaster University, Hamilton, Ontario, Canada, and rose to become a full Professor in 1982. He has always enjoyed teaching and mentoring students, residents and fellows. He served on the Editorial Board of BLOOD (1980-84), American Society of Hematology (ASH) Committee on Educational Affairs and Training (1984-87), NIH Hematology Study Section (1987-91), ASH Scientific Affairs Subcommittee on Hemoglobin/Red Cell (1989-1991), and Chair of Medical Advisory Board, the Thalassemia Foundation of Canada (2000-2002). He was elected to two honorific societies, the American Society for Clinical Investigation (1980) and the Association of American Physicians (1991). In 2003, Dr. Chui joined Chobanian and Avedisian School of Medicine, and was appointed a full Professor of Medicine, Pathology and Laboratory Medicine.

Expertise includes: Globin gene mutations; Hemoglobin diseases; Thalassmeias; and Regulation of fetal hemoglobin expression.

Other Positions

  • Member, Center for Regenerative Medicine, Boston University
  • Member, Center of Excellence in Sickle Cell Disease, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University


  • McGill University, MD
  • University of Maryland, BSc


  • Published on 2/4/2022

    Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1a stimulates fetal haemoglobin gene expression. Br J Haematol. 2022 Apr; 197(1):97-109. PMID: 35118652.

    Read at: PubMed
  • Published on 1/26/2022

    Aygun B, Bello A, Thompson AA, Davis L, Sun Y, Luo HY, Cui S, Chui DHK. Clinical phenotypes of three children with sickle cell disease caused by HbS/Sicilian (dß)0 -thalassemia deletion. Am J Hematol. 2022 04; 97(4):E156-E158. PMID: 35045200.

    Read at: PubMed
  • Published on 9/8/2021

    Patrinos GP, Chui DHK, Hardison RC, Steinberg MH. Strategies to improve pharmacogenomic-guided treatment options for patients with ß-hemoglobinopathies. Expert Rev Hematol. 2021 10; 14(10):883-885. PMID: 34490838.

    Read at: PubMed
  • Published on 6/24/2021

    Atroshi SD, Al-Allawi N, Chui DHK, Najmabadi H, Khailany RA. A Novel ß0-Thalassemia Mutation, HBB: c.356_357delTT [Codon 118 (-TT)] in an Iraqi Kurd. Hemoglobin. 2021 May; 45(3):212-214. PMID: 34167424.

    Read at: PubMed
  • Published on 3/1/2021

    Harris NS, Kavesh M, Beal SG, Winter WE, Chui DHK. When Hemoglobin Reported to Be A, S, and F Are Neither A, S, Nor F: A Tale of Two Patients. J Appl Lab Med. 2021 03 01; 6(2):543-549. PMID: 32995874.

    Read at: PubMed
  • Published on 11/29/2020

    Solano-Vargas M, Chui DHK, Rodriguez-Romero W. Alpha-thalassemia. Case report alpha-thalassemia in a Costa Rican family, A case report. Clin Case Rep. 2021 Jan; 9(1):291-293. PMID: 33489176.

    Read at: PubMed
  • Published on 10/22/2019

    Dai Y, Shaikho EM, Perez J, Wilson CA, Liu LY, White MR, Farrell JJ, Chui DHK, Sebastiani P, Steinberg MH. BCL2L1 is associated with ?-globin gene expression. Blood Adv. 2019 10 22; 3(20):2995-3001. PMID: 31648320.

    Read at: PubMed
  • Published on 6/1/2019

    Homsy E, Alghothani L, Chui DHK, Sood N. An Unusual Case of Low Hemoglobin Oxygen Saturation. Ann Am Thorac Soc. 2019 06; 16(6):756-759. PMID: 31149860.

    Read at: PubMed
  • Published on 4/16/2019

    Le CQ, Myers G, Habara A, Jearawiriyapaisarn N, Murphy GJ, Chui DHK, Steinberg MH, Engel JD, Cui S. Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis. Blood. 2019 05 30; 133(22):2455-2459. PMID: 30992270.

    Read at: PubMed
  • Published on 1/31/2019

    Xu S, Luk K, Yao Q, Shen AH, Zeng J, Wu Y, Luo HY, Brendel C, Pinello L, Chui DHK, Wolfe SA, Bauer DE. Editing aberrant splice sites efficiently restores ß-globin expression in ß-thalassemia. Blood. 2019 05 23; 133(21):2255-2262. PMID: 30704988.

    Read at: PubMed

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