Claudia L. Satizabal, PhD

Adjunct Assistant Professor, Neurology

Claudia Satizabal
72 E. Concord St Robinson (B)


Prior to joining the Framingham Heart Study in 2013, Satizabal earned her doctorate degree, studying the relationship between inflammatory proteins and cerebrovascular and neurodegenerative MRI markers of abnormal brain aging in the French Three-City Study at the INSERM Neuro-Epidemiology laboratory of the Pierre and Marie Curie University in Paris. In 2007, she was awarded a two-year Utrecht Excellence Scholarship to pursue a master’s degree in epidemiology from Utrecht University. In addition to her work at BUSM and the FHS, Satizabal is actively involved in the neurology and cognitive working groups of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, where she leads projects investigating the genetic variation in fine motor speed, visual memory, and subcortical brain structures. She participates in several other international collaborations including the AD Cohorts Consortium and the replication phase of the AD sequencing project. She is currently investigating the impact of midlife obesity, as well as different dietary, inflammatory and neurotrophic biomarkers, in association with stroke, cognitive function, MRI markers of abnormal brain aging and dementia.

Other Positions

  • Investigator, Framingham Heart Study


  • Pierre and Marie Curie University (Paris VI), PhD
  • Utrecht University, MSc
  • Universidad de Los Andes, BSc


  • Published on 2/1/2024

    Krefman AE, Stephen J, Carolan P, Sedaghat S, Mansolf M, Soumare A, Gross AL, Aiello AE, Singh-Manoux A, Ikram MA, Helmer C, Tzourio C, Satizabal C, Levine DA, Lloyd-Jones D, Briceño EM, Sorond FA, Wolters FJ, Himali J, Launer LJ, Zhao L, Haan M, Lopez OL, Debette S, Seshadri S, Judd SE, Hughes TM, Gudnason V, Scholtens D, Allen NB. Cohort Profile: Dementia Risk Prediction Project (DRPP). Int J Epidemiol. 2024 Feb 01; 53(1). PMID: 38339864.

    Read at: PubMed
  • Published on 1/31/2024

    Melgarejo JD, Patil D, Mena LJ, Vatcheva KP, Garcia JA, Satizabal CL, Chavez CA, Pirela RV, Silva E, Calmon G, Lee JH, Terwilliger JD, Seshadri S, Maestre GE. Association of Variability and Hypertensive Loads in 24-h Blood Pressure with Mortality and Cardiovascular Risk. Am J Hypertens. 2024 Jan 31. PMID: 38294177.

    Read at: PubMed
  • Published on 1/30/2024

    Pase MP, Himali JJ, Puerta R, Beiser AS, Gonzales MM, Satizabal CL, Yang Q, Aparicio HJ, Kojis DJ, Decarli CS, Lopez OL, Longstreth W, Gudnason V, Mosley TH, Bis JC, Fohner A, Psaty BM, Boada M, García-González P, Valero S, Marquié M, Tracy R, Launer LJ, Ruiz A, Fornage M, Seshadri S. Association of Plasma YKL-40 With MRI, CSF, and Cognitive Markers of Brain Health and Dementia. Neurology. 2024 Feb 27; 102(4):e208075. PMID: 38290090.

    Read at: PubMed
  • Published on 1/20/2024

    Mei H, Simino J, Li L, Jiang F, Bis JC, Davies G, Hill WD, Xia C, Gudnason V, Yang Q, Lahti J, Smith JA, Kirin M, De Jager P, Armstrong NJ, Ghanbari M, Kolcic I, Moran C, Teumer A, Sargurupremraj M, Mahmud S, Fornage M, Zhao W, Satizabal CL, Polasek O, Räikkönen K, Liewald DC, Homuth G, Callisaya M, Mather KA, Windham BG, Zemunik T, Palotie A, Pattie A, van der Auwera S, Thalamuthu A, Knopman DS, Rudan I, Starr JM, Wittfeld K, Kochan NA, Griswold ME, Vitart V, Brodaty H, Gottesman R, Cox SR, Psaty BM, Boerwinkle E, Chasman DI, Grodstein F, Sachdev PS, Srikanth V, Hayward C, Wilson JF, Eriksson JG, Kardia SLR, Grabe HJ, Bennett DA, Ikram MA, Deary IJ, van Duijn CM, Launer L, Fitzpatrick AL, Seshadri S, Bressler J, Debette S, Mosley TH. Multi-omics and pathway analyses of genome-wide associations implicate regulation and immunity in verbal declarative memory performance. Alzheimers Res Ther. 2024 Jan 20; 16(1):14. PMID: 38245754.

    Read at: PubMed
  • Published on 1/13/2024

    Sun X, Bulekova K, Yang J, Lai M, Pitsillides AN, Liu X, Zhang Y, Guo X, Yong Q, Raffield LM, Rotter JI, Rich SS, Abecasis G, Carson AP, Vasan RS, Bis JC, Psaty BM, Boerwinkle E, Fitzpatrick AL, Satizabal CL, Arking DE, Ding J, Levy D, Liu C. Association analysis of mitochondrial DNA heteroplasmic variants: methods and application. medRxiv. 2024 Jan 13. PMID: 38260412.

    Read at: PubMed
  • Published on 12/26/2023

    Satizabal CL, Beiser AS, Fletcher E, Seshadri S, DeCarli C. A novel neuroimaging signature for ADRD risk stratification in the community. Alzheimers Dement. 2023 Dec 26. PMID: 38147416.

    Read at: PubMed
  • Published on 11/3/2023

    Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I, Lindbohm JV, Duggan MR, Meirelles O, Harris SE, Gudmundsdottir V, Taylor AM, Henry A, Beiser AS, Shojaie A, Coors A, Fitzpatrick AL, Langenberg C, Satizabal CL, Sitlani CM, Wheeler E, Tucker-Drob EM, Bressler J, Coresh J, Bis JC, Candia J, Jennings LL, Pietzner M, Lathrop M, Lopez OL, Redmond P, Gerszten RE, Rich SS, Heckbert SR, Austin TR, Hughes TM, Tanaka T, Emilsson V, Vasan RS, Guo X, Zhu Y, Tzourio C, Rotter JI, Walker KA, Ferrucci L, Kivimäki M, Breteler MMB, Cox SR, Debette S, Mosley TH, Gudnason VG, Launer LJ, Psaty BM, Seshadri S, Fornage M. Identification of circulating proteins associated with general cognitive function among middle-aged and older adults. Commun Biol. 2023 Nov 03; 6(1):1117. PMID: 37923804.

    Read at: PubMed
  • Published on 10/27/2023

    Sarnowski C, Huan T, Ma Y, Joehanes R, Beiser A, DeCarli CS, Heard-Costa NL, Levy D, Lin H, Liu CT, Liu C, Meigs JB, Satizabal CL, Florez JC, Hivert MF, Dupuis J, De Jager PL, Bennett DA, Seshadri S, Morrison AC. Multi-tissue epigenetic analysis identifies distinct associations underlying insulin resistance and Alzheimer's disease at CPT1A locus. Clin Epigenetics. 2023 Oct 27; 15(1):173. PMID: 37891690.

    Read at: PubMed
  • Published on 10/19/2023

    Petrea RE, Pinheiro A, Demissie S, Ekenze O, Aparicio HJ, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S, Lioutas VA, Rafael Romero J. Hypertension Trends and White Matter Brain Injury in the Offspring Framingham Heart Study Cohort. Hypertension. 2024 Jan; 81(1):87-95. PMID: 37855140.

    Read at: PubMed
  • Published on 10/10/2023

    Gonzales MM, Vela G, Philip V, Trevino H, LaRoche A, Wang CP, Parent DM, Kautz T, Satizabal CL, Tanner J, O'Bryant S, Maestre G, Tracy RP, Seshadri S. Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort. Neurology. 2023 Oct 10; 101(15):e1531-e1541. PMID: 37813589.

    Read at: PubMed

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