Claudia L. Satizabal, PhD
Adjunct Assistant Professor, Neurology
Biography
Prior to joining the Framingham Heart Study in 2013, Satizabal earned her doctorate degree, studying the relationship between inflammatory proteins and cerebrovascular and neurodegenerative MRI markers of abnormal brain aging in the French Three-City Study at the INSERM Neuro-Epidemiology laboratory of the Pierre and Marie Curie University in Paris. In 2007, she was awarded a two-year Utrecht Excellence Scholarship to pursue a master’s degree in epidemiology from Utrecht University. In addition to her work at BUSM and the FHS, Satizabal is actively involved in the neurology and cognitive working groups of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, where she leads projects investigating the genetic variation in fine motor speed, visual memory, and subcortical brain structures. She participates in several other international collaborations including the AD Cohorts Consortium and the replication phase of the AD sequencing project. She is currently investigating the impact of midlife obesity, as well as different dietary, inflammatory and neurotrophic biomarkers, in association with stroke, cognitive function, MRI markers of abnormal brain aging and dementia.
Other Positions
- Investigator, Framingham Heart Study
Websites
Education
- Pierre and Marie Curie University (Paris VI), PhD
- Utrecht University, MSc
- Universidad de Los Andes, BSc
Publications
- Published on 1/1/2025
Charisis S, Mourtzi N, Scott MR, Ntanasi E, Mamalaki E, Hatzimanolis A, Ramirez A, Lambert JC, Yannakoulia M, Kosmidis M, Dardiotis E, Hadjigeorgiou G, Sakka P, Satizabal CL, Beiser A, Yang Q, Georgakis M?, Seshadri S, Scarmeas N. Genetic predisposition to high circulating levels of interleukin 6 and risk for Alzheimer's disease. Discovery and replication. J Prev Alzheimers Dis. 2025 Jan; 12(1):100018. PMID: 39800457.
Read at: PubMed - Published on 12/30/2024
Liu X, Maillard P, Barisano G, Caprihan A, Cen S, Shao X, Jann K, Ringman JM, Lu H, Arfanakis K, DeCarli CS, Gold BT, Seshadri S, Satizabal CL, Beiser AS, Habes M, Kramer JH, Stables L, Singh H, Helmer KG, Greenberg SM, Wang DJJ. MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts. Alzheimers Dement. 2025 Feb; 21(2):e14453. PMID: 39740225.
Read at: PubMed - Published on 12/18/2024
Kern KC, Vohra M, Thirion ML, Wang DJJ, Wilcock DM, Thompson JF, Rosenberg GA, Sagare A, Moghekar A, Lu H, Lee T, Elahi FM, Satizabal CL, Tracy R, Seshadri S, Schwab K, Helmer K, Singh H, Kivisäkk P, Greenberg SM, Vossel K, Kramer JH, Maillard P, DeCarli CS, Hinman JD. White matter free water mediates the associations between placental growth factor, white matter hyperintensities, and cognitive status. Alzheimers Dement. 2025 Feb; 21(2):e14408. PMID: 39692213.
Read at: PubMed - Published on 12/1/2024
Hu YH, Meirelles O, Shiroma EJ, Satizabal CL, Seshadri S, Tracy RP, Gudnason V, Launer LJ. Peripheral risk factors and their role in biomarker-based screening for dementia in the community. Alzheimers Dement. 2024 Dec; 20(12):8556-8565. PMID: 39718159.
Read at: PubMed - Published on 11/28/2024
van Lent DM, Jacques PF, Charisis SM, Mesa HG, Satizabal C, Yuan C, Vasan RS, Seshadri S, Beiser A, Himali JJ, Jacob ME. Dietary inflammatory index scores and cognitive aging: results from the Framingham heart Study offspring cohort. medRxiv. 2024 Nov 28. PMID: 39649578.
Read at: PubMed - Published on 11/21/2024
Luckey AM, Ghosh S, Wang CP, Beiser A, Bernal R, Li Z, Mbangdadji D, Fadaee E, Snoussi H, Dediós AGV, Trevino HA, Goss M, Hillmer LJ, Bauer CE, Staffaroni AM, Stables L, Albert M, Himali JJ, Mosley TH, Forsberg L, Guðnason V, Singh B, Singh H, Schwab K, Kramer JH, Rosenberg GA, Helmer KG, Greenberg SM, Habes M, Wang DJJ, Gold BT, Lu H, Caprihan A, Fornage M, Launer LJ, Arfanakis K, Seshadri S, DeCarli C, Maillard P, Satizabal CL. Biological validation of peak-width of skeletonized mean diffusivity as a VCID biomarker: The MarkVCID Consortium. Alzheimers Dement. 2024 Dec; 20(12):8814-8824. PMID: 39569745.
Read at: PubMed - Published on 11/18/2024
Stefanidou M, Himali JJ, Bernal R, Satizabal C, Devinsky O, Romero JR, Beiser AS, Seshadri S, Friedman D. Association of cognitive and structural correlates of brain aging and incident epilepsy. The Framingham Heart Study. Epilepsia. 2025 Jan; 66(1):160-169. PMID: 39555677.
Read at: PubMed - Published on 10/29/2024
Satizabal CL, Himali JJ, Conner SC, Beiser AS, Maillard P, Vasan RS, DeCarli C, Seshadri S. Circulating adipokines and MRI markers of brain aging in middle-aged adults from the community. J Alzheimers Dis. 2024 Nov; 102(2):449-458. PMID: 39625328.
Read at: PubMed - Published on 10/21/2024
García-Marín LM, Campos AI, Diaz-Torres S, Rabinowitz JA, Ceja Z, Mitchell BL, Grasby KL, Thorp JG, Agartz I, Alhusaini S, Ames D, Amouyel P, Andreassen OA, Arfanakis K, Arias-Vasquez A, Armstrong NJ, Athanasiu L, Bastin ME, Beiser AS, Bennett DA, Bis JC, Boks MPM, Boomsma DI, Brodaty H, Brouwer RM, Buitelaar JK, Burkhardt R, Cahn W, Calhoun VD, Carmichael OT, Chakravarty M, Chen Q, Ching CRK, Cichon S, Crespo-Facorro B, Crivello F, Dale AM, Smith GD, de Geus EJC, De Jager PL, de Zubicaray GI, Debette S, DeCarli C, Depondt C, Desrivières S, Djurovic S, Ehrlich S, Erk S, Espeseth T, Fernández G, Filippi I, Fisher SE, Fleischman DA, Fletcher E, Fornage M, Forstner AJ, Francks C, Franke B, Ge T, Goldman AL, Grabe HJ, Green RC, Grimm O, Groenewold NA, Gruber O, Gudnason V, Håberg AK, Haukvik UK, Heinz A, Hibar DP, Hilal S, Himali JJ, Ho BC, Hoehn DF, Hoekstra PJ, Hofer E, Hoffmann W, Holmes AJ, Homuth G, Hosten N, Ikram MK, Ipser JC, Jack CR, Jahanshad N, Jönsson EG, Kahn RS, Kanai R, Klein M, Knol MJ, Launer LJ, Lawrie SM, Hellard SL, Lee PH, Lemaître H, Li S, Liewald DCM, Lin H, Longstreth WT, Lopez OL, Luciano M, Maillard P, Marquand AF, Martin NG, Martinot JL, Mather KA, Mattay VS, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mirza-Schreiber N, Milaneschi Y, Mosley TH, Mühleisen TW, Müller-Myhsok B, Maniega SM, Nauck M, Nho K, Niessen WJ, Nöthen MM, Nyquist PA, Oosterlaan J, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Psaty BM, Pütz B, Reppermund S, Rietschel MD, Risacher SL, Romanczuk-Seiferth N, Romero-Garcia R, Roshchupkin GV, Rotter JI, Sachdev PS, Sämann PG, Saremi A, Sargurupremraj M, Saykin AJ, Schmaal L, Schmidt H, Schmidt R, Schofield PR, Scholz M, Schumann G, Schwarz E, Shen L, Shin J, Sisodiya SM, Smith AV, Smoller JW, Soininen HS, Steen VM, Stein DJ, Stein JL, Thomopoulos SI, Toga AW, Tordesillas-Gutiérrez D, Trollor JN, Valdes-Hernandez MC, van T Ent D, van Bokhoven H, van der Meer D, van der Wee NJA, Vázquez-Bourgon J, Veltman DJ, Vernooij MW, Villringer A, Vinke LN, Völzke H, Walter H, Wardlaw JM, Weinberger DR, Weiner MW, Wen W, Westlye LT, Westman E, White T, Witte AV, Wolf C, Yang J, Zwiers MP, Ikram MA, Seshadri S, Thompson PM, Satizabal CL, Medland SE, Rentería ME. Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries. Nat Genet. 2024 Nov; 56(11):2333-2344. PMID: 39433889.
Read at: PubMed - Published on 9/16/2024
Chen J, Ragab AAY, Doyle MF, Alosco ML, Fang Y, Mez J, Satizabal CL, Qiu WQ, Murabito JM, Lunetta KL. Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort. Alzheimers Dement. 2024 Nov; 20(11):7465-7478. PMID: 39282876.
Read at: PubMed
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