Beth C. Bragdon, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

I am interested in the effects of trauma and repair as it pertains to the musculoskeletal system with an emphasis on stem/progenitor cell recruitment, differentiation, and formation of bone tissue and the signaling pathways involved with these processes. Currently, the stem cell population(s) that drives heterotopic ossification (HO) due to trauma or even fracture repair is unknown. My work focuses on 1) the identification and isolation of the stem/progenitor cell populations that contribute to post-natal bone formation (HO and fracture) and 2) compare the transcriptome of these different populations for similarities and identify key signaling pathways that could be used as targets for future therapy.

Publications

  • Published 6/11/2024

    Blank K, Ekanayake D, Cooke M, Bragdon B, Hussein A, Gerstenfeld L. Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation. J Cell Physiol. 2024 Aug; 239(8):e31285. PMID: 38860464.

    Read at: PubMed

  • Published 1/30/2023

    Liu Y, Ilinski A, Gerstenfeld LC, Bragdon B. Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation. Front Physiol. 2023; 14:1106474. PMID: 36793419.

    Read at: PubMed

  • Published 1/23/2023

    Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation. Bone Rep. 2023 Jun; 18:101657. PMID: 37425193.

    Read at: PubMed

  • Published 3/26/2022

    Bragdon BC, Bennie A, Molinelli A, Liu Y, Gerstenfeld LC. Post natal expression of Prx1 labels appendicular restricted progenitor cell populations of multiple tissues. J Cell Physiol. 2022 May; 237(5):2550-2560. PMID: 35338481.

    Read at: PubMed

  • Published 12/10/2021

    Lu D, Demissie S, Horowitz NB, Gower AC, Lenburg ME, Alekseyev YO, Hussein AI, Bragdon B, Liu Y, Daukss D, Page JM, Webster MZ, Schlezinger JJ, Morgan EF, Gerstenfeld LC. Temporal and Quantitative Transcriptomic Differences Define Sexual Dimorphism in Murine Postnatal Bone Aging. JBMR Plus. 2022 Feb; 6(2):e10579. PMID: 35229061.

    Read at: PubMed

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Websites

Education

  • University of Maine, PhD
  • University of Maine, BS

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