Anthony Hollenberg, MD
President
Biography
The focus of my research program is the thyroid with a focus on the role of gland development and the actions of its hormones. To accomplish these goals we have built a unique program in thyroid gland development from endoderm in order to derive new therapies for hypothyroidism. Additionally, we explore thyroid hormone action and nuclear receptor signaling as a model system. Our work has uncovered a unique role for nuclear receptor co-regulatory proteins termed nuclear corepressors in thyroid hormone signaling and determining hormone sensitivity. Furthermore, we have used our understanding of thyroid hormone signaling to identify new biomarkers of its action.
My laboratory has a long-standing interest in how thyroid hormone mediates its effects in context of genomic regulation. Specifically we were amongst the first to begin to differentiate how thyroid hormone is able to stimulate both positive and negative gene regulation. Studies in this area allowed us to be able to characterize the interaction of the thyroid hormone receptor with its cofactors which are necessary for genomic regulation.
We were pioneers in the use of knock-out mouse models to validate the role of thyroid hormone receptor co-factors, specifically nuclear corepressors, in thyroid hormone signaling. These studies allowed us to demonstrate that the tissue-specific expression of co-factors determines a set hormone sensitivity. This has important ramifications for thyroid/steroid action in general. Furthermore these studies have allowed us to better understand the specificity of coregulator interactions with the thyroid hormone receptor and their role in disease.
In addition to our work on thyroid hormone action we have also had a long standing interest in the intersection of the regulation of biomarkers of thyroid hormone action including the regulation of the hypothalamic pituitary thyroid axis by thyroid hormone and other metabolic pathways. Our work has demonstrated that these pathways and others are linked at the molecular and physiological level. Furthermore, they must be considered when trying to understand the effects of thyroid hormone signaling.
Most recently, because of our interest in defining the etiology of the set point of the HPT axis, we became interested in creating a durable thyroid follicular cell model. To accomplish this we began a complete collaboration with the Kotton laboratory at Boston University and have successfully developed the molecular paradigm to develop thyroid follicular cells from ESCs or IPSCs across multiple species. Additionally we have established that these derived cells function in vivo.
Other Positions
- Professor, Medicine, Boston University Chobanian & Avedisian School of Medicine
Publications
- Published on 1/6/2025
Ritter MJ, Amano I, Hollenberg AN. Transcriptional Cofactors for Thyroid Hormone Receptors. Endocrinology. 2025 Jan 06; 166(2). PMID: 39679543.
Read at: PubMed - Published on 12/3/2024
Xu X, Mendoza A, Krumm CS, Su S, Acuña M, Bare CJ, Holman CD, Cortopassi M, Nicholls HT, Dartigue V, Hollenberg AN, Lee AH, Hagen SJ, Cohen DE. ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress. Sci Signal. 2024 Dec 03; 17(865):eadk7971. PMID: 39626011.
Read at: PubMed - Published on 11/7/2024
Undeutsch HJ, Posabella A, Alber AB, Bawa PS, Villacorta-Martin C, Wang F, Ikonomou L, Kotton DN, Hollenberg AN. Derivation of transplantable human thyroid follicular epithelial cells from induced pluripotent stem cells. Stem Cell Reports. 2024 Dec 10; 19(12):1690-1705. PMID: 39515316.
Read at: PubMed - Published on 10/29/2024
Soares De Oliveira L, Kaserman JE, Van Der Spek AH, Lee NJ, Undeutsch HJ, Werder RB, Wilson AA, Hollenberg AN. Thyroid hormone receptor beta (THRß1) is the major regulator of T3 action in human iPSC-derived hepatocytes. Mol Metab. 2024 Dec; 90:102057. PMID: 39481850.
Read at: PubMed - Published on 10/1/2024
Hu Y, Soares De Oliveira L, Falize K, Paul van Trotsenburg AS, Fliers E, Kaserman JE, Wilson AA, Hollenberg AN, Bruinstroop E, Boelen A. Disturbed function of TBL1X has a differential effect on T3-regulated gene expression in two human liver cell models. Eur Thyroid J. 2024 Oct 01; 13(5). PMID: 39316725.
Read at: PubMed - Published on 7/26/2024
Ritter MJ, Amano I, van der Spek AH, Gower AC, Undeutsch HJ, Rodrigues VAP, Daniel HE, Hollenberg AN. Nuclear Receptor Corepressors NCOR1 and SMRT Regulate Metabolism via Intestinal Regulation of Carbohydrate Transport. Endocrinology. 2024 Jul 26; 165(9). PMID: 39106294.
Read at: PubMed - Published on 7/22/2024
Maddox SA, Ponomareva OY, Zaleski CE, Chen MX, Vella KR, Hollenberg AN, Klengel C, Ressler KJ. Evidence for thyroid hormone regulation of amygdala-dependent fear-relevant memory and plasticity. Mol Psychiatry. 2025 Jan; 30(1):201-212. PMID: 39039155.
Read at: PubMed - Published on 12/11/2023
Cho YW, Fu Y, Huang CJ, Wu X, Ng L, Kelley KA, Vella KR, Berg AH, Hollenberg AN, Liu H, Forrest D. Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland. Commun Biol. 2023 Dec 11; 6(1):1253. PMID: 38081939.
Read at: PubMed - Published on 8/16/2023
Burris TP, de Vera IMS, Cote I, Flaveny CA, Wanninayake US, Chatterjee A, Walker JK, Steinauer N, Zhang J, Coons LA, Korach KS, Cain DW, Hollenberg AN, Webb P, Forrest D, Jetten AM, Edwards DP, Grimm SL, Hartig S, Lange CA, Richer JK, Sartorius CA, Tetel M, Billon C, Elgendy B, Hegazy L, Griffett K, Peinetti N, Burnstein KL, Hughes TS, Sitaula S, Stayrook KR, Culver A, Murray MH, Finck BN, Cidlowski JA. International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023. Pharmacol Rev. 2023 Nov; 75(6):1233-1318. PMID: 37586884.
Read at: PubMed - Published on 6/19/2023
Hu Y, Bruinstroop E, Hollenberg AN, Fliers E, Boelen A. The role of WD40 repeat-containing proteins in endocrine (dys)function. J Mol Endocrinol. 2023 Jul 01; 71(1). PMID: 37256579.
Read at: PubMed
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