Andrea Geisz, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

I am a basic scientist investigating the molecular mechanisms underlying acute and chronic pancreatitis, with emphasis on how genetic mutations in key pancreatitis susceptibility genes drive protease dysregulation and pancreatic inflammation. My research seeks to bridge the gap between mechanistic understanding of pancreatitis pathways and the development of targeted therapeutics. Additionally, I am exploring how chronic protease dysregulation and inflammatory states in genetically susceptible individuals may contribute to pancreatic cancer risk, with the goal of identifying biomarkers for early detection and developing therapeutic approaches to prevent or delay malignant transformation.

Publications

  • Published 5/20/2026

    Tran T, Geisz-Fremy A. Role of cathepsin B in spontaneous pancreatitis in T7D23A trypsinogen mutant mice. Pancreatology. 2026 May 20. PMID: 42259709.

    Read at: PubMed

  • Published 5/15/2026

    Kesaraju S, Li Y, Xing J, Ghadiri M, Tracy M, Wannemo K, Holder A, Zhao P, Wu Q, Khan MA, Wood S, Durgam S, Kainov J, Rana N, Sidahmed M, Hyoju S, Smith L, Matthews JM, Wu R, Tay S, Khalili-Araghi F, Geisz-Fremy A, Rana M, Oakes SA, Shen L, Weber CR. Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport. Gastroenterology. 2026 May 15. PMID: 42142543.

    Read at: PubMed

  • Published 12/18/2025

    Geisz-Fremy A. Pathologically relevant trypsinogen activation in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2026 Feb 01; 330(2):G87-G97. PMID: 41412572.

    Read at: PubMed

  • Published 5/8/2025

    Demcsák A, Tran T, Sahin-Tóth M, Geisz-Fremy A. Strain-specific differences in cerulein-induced acute and recurrent acute murine pancreatitis. Sci Rep. 2025 May 08; 15(1):16030. PMID: 40341748.

    Read at: PubMed

  • Published 3/6/2025

    Sándor M, Scheers I, Masamune A, Witt H, LaRusch J, Chen JM, Németh BC, Geisz A, Uc A, Sahin-Tóth M. AlphaMissense versus laboratory-based pathogenicity prediction of 13 novel missense CPA1 variants from pancreatitis cases. Gut. 2025 Mar 06; 74(4):678-679. PMID: 39256032.

    Read at: PubMed

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Websites

Education

  • University of Szeged, PhD
  • University of Szeged, MS

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