Adam T. Labadorf, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Adam received his PhD in Bioinformatics from Boston University. His primary research interest is to better understand the genomics characteristics of neurodegeneration in human tissue using bioinformatics and machine learning approaches. His neurodegenerative disease research involves identifying commonalities and differences between different neurodegenerative diseases, with the goal of finding common pathological mechanisms that may lead to novel treatment modalities. He has particular expertise in the analysis of post mortem human brain tissue and cerebrospinal fluid transcriptomes, and has made significant contributions to our understanding of Huntington's, Parkinson's, and Chronic Traumatic Encephalopathy (CTE). He also has methodological interests in metatranscriptomics in contexts ranging from Caribbean coral ecologies to connections between the central nervous system and the human microbiome. In addition to his independent research, he serves as Director of Graduate Studies for the BU Bioinformatics Masters program, as Director of Bioinformatics for the VA PTSD Brain Bank, and is a member of the BU Alzheimer's Disease Research Center and BU CTE Center.

Publications

  • Published 6/1/2026

    Dayama G, Lee JR, Gupta S, Brion C, Connizzo BK, Labadorf AT, Myers RH, Lau NC. Transposable element small RNAs and large RNAs in aging brains and implications in Huntington's and Parkinson's disease. Genome Res. 2026 Jun 01; 36(6):1125-1140. PMID: 42209156.

    Read at: PubMed

  • Published 2/14/2026

    Pennington HE, Shapiro D, Empawi J, Aytan N, Alvarez V, Mez J, Alosco ML, Zhang X, McKee AC, Stein TD, Cherry JD, Labadorf A. Proteomic Analysis of Human Chronic Traumatic Encephalopathy Brain Implicates Proteasome and Ribosome Dysfunction in Disease Progression. bioRxiv. 2026 Feb 14. PMID: 41726919.

    Read at: PubMed

  • Published 1/31/2026

    Le NTT, Mercer RCC, Fang C, Sundaravadivelu A, Labadorf AT, Lin W, Kwan J, Blum B, Emili A, Harris DA. Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs. bioRxiv. 2026 Jan 31. PMID: 41659520.

    Read at: PubMed

  • Published 10/13/2025

    Bellio TA, Krunic A, Campion MS, Dupaguntla R, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppNL-G-F Mice. Aging Cell. 2025 Nov; 24(11):e70148. PMID: 41081549.

    Read at: PubMed

  • Published 10/13/2025

    Krunic A, Bellio TA, Cohen BZ, Labadorf A, Stein TD, Lin H, Mellott TJ, Blusztajn JK. Brain DNA Methylation Atlas of AppNL-G-F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline-Induced Resilience. Aging Cell. 2025 Nov; 24(11):e70241. PMID: 41081550.

    Read at: PubMed

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Websites

Education

  • Boston University, PhD
  • Colorado State University, MS
  • Dickinson College, BS

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