Adam Thomas Labadorf, PhD
Assistant Professor, Medicine
Biography
Adam received his PhD in Bioinformatics from Boston University. His primary research interest is to better understand the genomics characteristics of neurodegeneration in human tissue using bioinformatics and machine learning approaches. His neurodegenerative disease research involves identifying commonalities and differences between different neurodegenerative diseases, with the goal of finding common pathological mechanisms that may lead to novel treatment modalities. He has particular expertise in the analysis of post mortem human brain tissue and cerebrospinal fluid transcriptomes, and has made significant contributions to our understanding of Huntington’s, Parkinson’s, and Chronic Traumatic Encephalopathy (CTE). He also has methodological interests in metatranscriptomics in contexts ranging from Caribbean coral ecologies to connections between the central nervous system and the human microbiome. In addition to his independent research, he serves as Director of Graduate Studies for the BU Bioinformatics Masters program, as Director of Bioinformatics for the VA PTSD Brain Bank, and is a member of the BU Alzheimer’s Disease Research Center and BU CTE Center.
Websites
Education
- Boston University, PhD
- Colorado State University, MS
- Dickinson College, BS
Publications
- Published on 10/25/2024
Dayama G, Gupta S, Connizzo BK, Labadorf AT, Myers RH, Lau NC. Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease. bioRxiv. 2024 Oct 25. PMID: 39484439.
Read at: PubMed - Published on 7/22/2024
Gallo CM, Kistler SA, Natrakul A, Labadorf AT, Beffert U, Ho A. APOER2 splicing repertoire in Alzheimer's disease: Insights from long-read RNA sequencing. PLoS Genet. 2024 Jul; 20(7):e1011348. PMID: 39038048.
Read at: PubMed - Published on 2/1/2024
Wu M, Hanly A, Gibson F, Fisher R, Rogers S, Park K, Zuger A, Kuang K, Kalin JH, Nocco S, Cole M, Xiao A, Agus F, Labadorf A, Beck S, Collard M, Cole PA, Alani RM. The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma. J Clin Invest. 2024 Feb 01; 134(6). PMID: 38300709.
Read at: PubMed - Published on 3/9/2023
Labadorf A, Agus F, Aytan N, Cherry J, Mez J, McKee A, Stein TD. Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain. BMC Med Genomics. 2023 Mar 09; 16(1):49. PMID: 36895005.
Read at: PubMed - Published on 2/17/2023
Carrasco Pro S, Hook H, Bray D, Berenzy D, Moyer D, Yin M, Labadorf AT, Tewhey R, Siggers T, Fuxman Bass JI. Widespread perturbation of ETS factor binding sites in cancer. Nat Commun. 2023 Feb 17; 14(1):913. PMID: 36808133.
Read at: PubMed - Published on 5/19/2022
Alvia M, Aytan N, Spencer KR, Foster ZW, Rauf NA, Guilderson L, Robey I, Averill JG, Walker SE, Alvarez VE, Huber BR, Mathais R, Cormier KA, Nicks R, Pothast M, Labadorf A, Agus F, Alosco ML, Mez J, Kowall NW, McKee AC, Brady CB, Stein TD. MicroRNA Alterations in Chronic Traumatic Encephalopathy and Amyotrophic Lateral Sclerosis. Front Neurosci. 2022; 16:855096. PMID: 35663558.
Read at: PubMed - Published on 5/10/2022
Ruan Z, Takamatsu-Yukawa K, Wang Y, Ushman ML, Labadorf AT, Ericsson M, Ikezu S, Ikezu T. Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia. Cell Rep. 2022 May 10; 39(6):110791. PMID: 35545052.
Read at: PubMed - Published on 2/19/2022
Gallo CM, Labadorf AT, Ho A, Beffert U. Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns. Genomics. 2022 Mar; 114(2):110318. PMID: 35192893.
Read at: PubMed - Published on 1/1/2022
Labadorf A. The National PTSD Brain Bank: Progress, Promise, and Vision. Psychiatry. 2022; 85(2):196-200. PMID: 35588489.
Read at: PubMed - Published on 9/20/2021
Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443. PMID: 34365507.
Read at: PubMed
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