Adam T. Labadorf, PhD

Assistant Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Adam received his PhD in Bioinformatics from Boston University. His primary research interest is to better understand the genomics characteristics of neurodegeneration in human tissue using bioinformatics and machine learning approaches. His neurodegenerative disease research involves identifying commonalities and differences between different neurodegenerative diseases, with the goal of finding common pathological mechanisms that may lead to novel treatment modalities. He has particular expertise in the analysis of post mortem human brain tissue and cerebrospinal fluid transcriptomes, and has made significant contributions to our understanding of Huntington's, Parkinson's, and Chronic Traumatic Encephalopathy (CTE). He also has methodological interests in metatranscriptomics in contexts ranging from Caribbean coral ecologies to connections between the central nervous system and the human microbiome. In addition to his independent research, he serves as Director of Graduate Studies for the BU Bioinformatics Masters program, as Director of Bioinformatics for the VA PTSD Brain Bank, and is a member of the BU Alzheimer's Disease Research Center and BU CTE Center.

Publications

  • Published 4/9/2025

    Han X, Zhang Y, Petrosky JN, Bald S, Sherva RM, Labadorf A, Cherry JD, Chung J, Farrell K, Abdolmohammadi B, Durape S, Martin BM, Palmisano JN, Farrell JJ, Alvarez VE, Huber BR, Dwyer B, Daneshvar DH, Dams-O'Connor K, Jun GR, Lunetta KL, Goldstein LE, Katz DI, Cantu RC, Shenton ME, Cummings JL, Reiman EM, Stern RA, Alosco ML, Tripodis Y, Farrer LA, Stein TD, Crary JF, McKee AC, Mez J. A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes. Cell Rep Med. 2025 Apr 09; 102084. PMID: 40239644.

    Read at: PubMed

  • Published 10/25/2024

    Dayama G, Gupta S, Connizzo BK, Labadorf AT, Myers RH, Lau NC. Transposable element small and long RNAs in aging brains and implications in Huntington's and Parkinson's disease. bioRxiv. 2024 Oct 25. PMID: 39484439.

    Read at: PubMed

  • Published 7/22/2024

    Gallo CM, Kistler SA, Natrakul A, Labadorf AT, Beffert U, Ho A. APOER2 splicing repertoire in Alzheimer's disease: Insights from long-read RNA sequencing. PLoS Genet. 2024 Jul; 20(7):e1011348. PMID: 39038048.

    Read at: PubMed

  • Published 2/1/2024

    Wu M, Hanly A, Gibson F, Fisher R, Rogers S, Park K, Zuger A, Kuang K, Kalin JH, Nocco S, Cole M, Xiao A, Agus F, Labadorf A, Beck S, Collard M, Cole PA, Alani RM. The CoREST repressor complex mediates phenotype switching and therapy resistance in melanoma. J Clin Invest. 2024 Feb 01; 134(6). PMID: 38300709.

    Read at: PubMed

  • Published 3/9/2023

    Labadorf A, Agus F, Aytan N, Cherry J, Mez J, McKee A, Stein TD. Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain. BMC Med Genomics. 2023 Mar 09; 16(1):49. PMID: 36895005.

    Read at: PubMed

View All 41 Publications:   View Full Profile in BUMC

Websites

Education

  • Boston University, PhD
  • Colorado State University, MS
  • Dickinson College, BS

View all profiles