Yuriy O. Alekseyev, PhD

Research Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Yuriy serves as director of BU Microarray Core Resource facility since 2007. Prior to joining BU, Yuriy was a post-doctoral associate with Dr. John Essigmann at MIT where he used animal models to study transcriptional networks affected by a human hepatocarcinogen Aflatoxin B1 and by chemoprevention agents that suppress aflatoxin-induced carcinogenesis.

Yuriy earned a Ph.D. in Biochemistry from the Department of Chemistry at Wayne State University in the laboratory of Dr. Romano, where he studied mechanisms of DNA replication, mutagenesis and repair of carcinogenic lesions. Prior to that he received a M.S. in biotechnology from Moscow Academy of Fine Chemical Technology and worked in Moscow State Scientific Center GNIIGenetica where he studied plant toxins and took part in development of immunotoxins for potential use in cancer therapy and organ transplantation.

Publications

  • Published 10/2/2025

    Yabaji SM, Zhernovkov V, Araveti PB, Lata S, Rukhlenko OS, Abdullatif SA, Vanvalkenburg A, Alekseyev YO, Ma Q, Dayama G, Lau NC, Johnson WE, Bishai WR, Crossland NA, Campbell JD, Kholodenko BN, Gimelbrant AA, Kobzik L, Kramnik I. Lipid peroxidation and type I interferon coupling fuels pathogenic macrophage activation causing tuberculosis susceptibility. Elife. 2025 Oct 02; 14. PMID: 41037321.

    Read at: PubMed

  • Published 10/1/2025

    Milstone ZJ, Moreira-Bouchard JD, Smith KK, Anilkumar A, Gower AC, Alekseyev Y, Cunha JA, Fisher N, Legler L, Lepson J, Tao BS, Williams C, Benjamin EJ, Levy D, Mitchell RN, Padera RF, Shah H, Choi SH, Gopal DM, Tucker NR, Fetterman JL. Multiomics investigation of the female hypertensive human heart. Physiol Rep. 2025 Oct; 13(19):e70586. PMID: 41036600.

    Read at: PubMed

  • Published 5/15/2025

    Flores EY, Mithal A, Bawa P, Wang F, D'Amico A, O'Connell AK, Gertje HP, Tseng AE, Crossland NA, Alekseyev Y, Mostoslavsky G. Human-induced Pluripotent Stem Cell-derived Gut Organoids Recapitulate Regional Specific Genetic Programs and a Role for cAMP in Lineage Specification. Cell Mol Gastroenterol Hepatol. 2025; 19(9):101534. PMID: 40381917.

    Read at: PubMed

  • Published 3/11/2025

    Wang Y, Wang X, Alabdullatif S, Homma ST, Alekseyev YO, Zhou L. Expansion and pathogenic activation of skeletal muscle-resident macrophages in mdx5cv/Ccr2-/- mice. Proc Natl Acad Sci U S A. 2025 Mar 18; 122(11):e2410095122. PMID: 40067893.

    Read at: PubMed

  • Published 7/31/2024

    Sun Y, Benmhammed H, Al Abdullatif S, Habara A, Fu E, Brady J, Williams C, Ilinski A, Sharma A, Mahdaviani K, Alekseyev YO, Campbell JD, Steinberg MH, Cui S. PGC-1a agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease. Sci Adv. 2024 Aug 02; 10(31):eadn8750. PMID: 39083598.

    Read at: PubMed

View All 54 Publications:   View Full Profile in BUMC

Other Positions

  • Member, BU-BMC Cancer Center
    Boston University
  • Director, Microarray Resource Core
    Boston University Chobanian & Avedisian School of Medicine
  • Member, Genome Science Institute
    Boston University
  • Graduate Faculty (Primary Mentor of Grad Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Wayne State University, PhD
  • Moscow State University of Fine Chem Technologies, MS
  • Moscow State University of Fine Chem Technologies, BS

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