Vijaya B. Kolachalama, PhD, FAHA

Assistant Professor, Medicine

Vijaya Kolachalama
617.358.7253
72 East Concord Street, Evans 636

Biography

The Kolachalama laboratory is broadly focused on developing advanced machine learning algorithms to tackle complex biomedical datasets, with particular emphasis on medical imaging.

Phenotyping neurodegeneration using machine learning: We build machine learning frameworks to process multimodal data and identify specific signatures of neurodegeneration. We have experience in dealing with large data cohorts such as the Framingham Heart Study and established several computational pipelines to efficiently process volumetric images of the brain, neuropathology and other modes of data and use them for further analysis.

Digital pathology: We develop computational frameworks based on deep learning to assist the pathologist. Our current application areas include kidney disease, lung cancer and colorectal cancer. 

Machine learning for musculoskeletal diseases: We develop machine learning frameworks to bring efficiency to the analysis of large-scale studies such as Osteoarthritis Initiative (OAI) and Multicenter osteoarthritis (MOST) study. We are particularly interested to quantify structures that are responsible for pain and factors that contribute to the progression of knee osteoarthritis.

Devices, drugs and interfaces: We use a multidisciplinary approach to quantify device-artery interactions and the interfacial mechanisms driving the performance of endovascular devices. Previous studies by us and our collaborators have explained the role of physiologic factors in modulating spatiotemporal arterial distribution patterns for drug-eluting devices as a function of intrinsic device design, relative device position and pulsatile nature of blood flow. We have extended models simulating idealized settings of physiology to real world issues and further examine arterial tissue response that varies due to procedural settings, device composition, arterial wall ultrastructure and disease, physiologic changes within complex vascular anatomies, vascular injury and the mode of drug delivery.

Other Positions

  • Member, Whitaker Cardiovascular Institute, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Founding Assistant Professor, Computing & Data Sciences Administration, Boston University School of Medicine, Graduate Medical Sciences

Education

  • Indian Institute of Technology, Kharagpur, India, BS
  • University of Southampton, UK, PhD

Classes Taught

  • GMSMS650

Publications

  • Published on 8/31/2021

    Xue C, Karjadi C, Paschalidis IC, Au R, Kolachalama VB. Detection of dementia on voice recordings using deep learning: a Framingham Heart Study. Alzheimers Res Ther. 2021 Aug 31; 13(1):146. PMID: 34465384.

    Read at: PubMed
  • Published on 7/28/2021

    Zhang JD, Baker MJ, Liu Z, Kabir KMM, Kolachalama VB, Yates DH, Donald WA. Medical diagnosis at the point-of-care by portable high-field asymmetric waveform ion mobility spectrometry: a systematic review and meta-analysis. J Breath Res. 2021 Jul 28; 15(4). PMID: 34252887.

    Read at: PubMed
  • Published on 7/27/2021

    Amini S, Zhang L, Hao B, Gupta A, Song M, Karjadi C, Lin H, Kolachalama VB, Au R, Paschalidis IC. An Artificial Intelligence-Assisted Method for Dementia Detection Using Images from the Clock Drawing Test. J Alzheimers Dis. 2021 Jul 27. PMID: 34334396.

    Read at: PubMed
  • Published on 7/1/2021

    Xu D, Zhou F, Sun W, Chen L, Lan L, Li H, Xiao F, Li Y, Kolachalama VB, Li Y, Wang X, Xu H. Relationship Between Serum Severe Acute Respiratory Syndrome Coronavirus 2 Nucleic Acid and Organ Damage in Coronavirus 2019 Patients: A Cohort Study. Clin Infect Dis. 2021 07 01; 73(1):68-75. PMID: 32720678.

    Read at: PubMed
  • Published on 5/23/2021

    Zheng Y, Cassol CA, Jung S, Veerapaneni D, Chitalia VC, Ren KYM, Bellur SS, Boor P, Barisoni LM, Waikar SS, Betke M, Kolachalama VB. Deep-Learning-Driven Quantification of Interstitial Fibrosis in Digitized Kidney Biopsies. Am J Pathol. 2021 08; 191(8):1442-1453. PMID: 34033750.

    Read at: PubMed
  • Published on 5/17/2021

    Weizenbaum EL, Fulford D, Torous J, Pinsky E, Kolachalama VB, Cronin-Golomb A. Smartphone-Based Neuropsychological Assessment in Parkinson's Disease: Feasibility, Validity, and Contextually Driven Variability in Cognition. J Int Neuropsychol Soc. 2021 May 17; 1-13. PMID: 33998438.

    Read at: PubMed
  • Published on 5/11/2021

    Chang GH, Park LK, Le NA, Jhun RS, Surendran T, Lai J, Seo H, Promchotichai N, Yoon G, Scalera J, Capellini TD, Felson DT, Kolachalama VB. Subchondral bone length in knee osteoarthritis: A deep learning derived imaging measure and its association with radiographic and clinical outcomes. Arthritis Rheumatol. 2021 May 11. PMID: 33973737.

    Read at: PubMed
  • Published on 3/14/2021

    Zhou X, Qiu S, Joshi PS, Xue C, Killiany RJ, Mian AZ, Chin SP, Au R, Kolachalama VB. Enhancing magnetic resonance imaging-driven Alzheimer's disease classification performance using generative adversarial learning. Alzheimers Res Ther. 2021 03 14; 13(1):60. PMID: 33715635.

    Read at: PubMed
  • Published on 12/1/2020

    Chang GH, Felson DT, Qiu S, Guermazi A, Capellini TD, Kolachalama VB. Correction to: Assessment of knee pain from MR imaging using a convolutional Siamese network. Eur Radiol. 2020 Dec; 30(12):6968. PMID: 32700018.

    Read at: PubMed
  • Published on 6/1/2020

    Qiu S, Joshi PS, Miller MI, Xue C, Zhou X, Karjadi C, Chang GH, Joshi AS, Dwyer B, Zhu S, Kaku M, Zhou Y, Alderazi YJ, Swaminathan A, Kedar S, Saint-Hilaire MH, Auerbach SH, Yuan J, Sartor EA, Au R, Kolachalama VB. Development and validation of an interpretable deep learning framework for Alzheimer's disease classification. Brain. 2020 06 01; 143(6):1920-1933. PMID: 32357201.

    Read at: PubMed

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