Valentina Perissi, PhD

Associate Professor, Biochemistry

Valentina Perissi
617.358.4563
72 E. Concord St Silvio Conte (K)

Biography

Valentina Perissi holds a Laurea in Molecular Biology from the University of Torino (Italy) and a PhD in Molecular Pathology from UCSD. After postdoctoral training in Epigenetics, Endocrinology and Metabolism in Dr. Geoff Rosenfeld’s HHMI laboratory at UCSD, she established an independent research group at Boston University. This transition was supported by a K99-R00 career development award from NIDDK and a Peter Paul Career Development Professorship from Boston University.

The overarching theme in the Perissi Lab is dissecting the molecular mechanisms that control metabolic adaptation in response to nutrients availability, cell differentiation and oxidative stress.
Current projects focus on two main areas:
1) Mechanisms regulating mitochondria-nuclear communication and genomic regulation of the mitochondrial stress response
2) Role of non-proteolytic K63 ubiquitination in the regulation of metabolic reprogramming.
Ongoing studies investigate these topics in the context of obesity-associated inflammation/insulin resistance and breast cancer.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Member, Genome Science Institute, Boston University

Education

  • University of California, San Diego, PhD
  • University of Torino, BSc

Classes Taught

  • GMSBI777

Publications

  • Published on 2/11/2020

    Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, Farmer SR. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Sci Rep. 2020 Feb 11; 10(1):2380. PMID: 32047213.

    Read at: PubMed
  • Published on 8/10/2019

    Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Opposing action of NCoR1 and PGC-1a in mitochondrial redox homeostasis. Free Radic Biol Med. 2019 11 01; 143:203-208. PMID: 31408725.

    Read at: PubMed
  • Published on 11/21/2018

    Cardamone MD, Orofino J, Labadorf A, Perissi V. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. 2018 11 21; (141). PMID: 30531713.

    Read at: PubMed
  • Published on 8/21/2018

    Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann Neurol. 2018 08; 84(2):289-301. PMID: 30014514.

    Read at: PubMed
  • Published on 3/1/2018

    Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 03 01; 69(5):757-772.e7. PMID: 29499132.

    Read at: PubMed
  • Published on 5/24/2017

    Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone M, Enríquez-Zarralanga V, Ritou E, Aprahamian T, Oliveira MF, Corkey BE, Perissi V, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis. EMBO Rep. 2017 Jul; 18(7):1123-1138. PMID: 28539390.

    Read at: PubMed
  • Published on 12/30/2016

    Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772. PMID: 28039360.

    Read at: PubMed
  • Published on 10/31/2016

    Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 01; 6(1):125-137. PMID: 28123943.

    Read at: PubMed
  • Published on 6/12/2015

    Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31; 290(31):19044-54. PMID: 26070566.

    Read at: PubMed
  • Published on 6/19/2014

    Cardamone MD, Tanasa B, Chan M, Cederquist CT, Andricovich J, Rosenfeld MG, Perissi V. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR?. Cell Rep. 2014 Jul 10; 8(1):163-76. PMID: 24953653.

    Read at: PubMed

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