Valentina Perissi, PhD

Associate Professor, Biochemistry

Valentina Perissi
617.358.4567
72 E. Concord St Silvio Conte (K)

Biography

Valentina Perissi holds a Laurea in Molecular Biology from the University of Torino (Italy) and a PhD in Molecular Pathology from UCSD. After postdoctoral training in Epigenetics, Endocrinology and Metabolism in Dr. Geoff Rosenfeld’s HHMI laboratory at UCSD, she established an independent research group at Boston University. This transition was supported by a K99-R00 career development award from NIDDK and a Peter Paul Career Development Professorship from Boston University.

The overarching theme in the Perissi Lab is dissecting the molecular mechanisms that control metabolic adaptation in response to nutrients availability, cell differentiation and oxidative stress.
Current projects focus on two main areas:
1) Mechanisms regulating mitochondria-nuclear communication and genomic regulation of the mitochondrial stress response
2) Role of non-proteolytic K63 ubiquitination in the regulation of metabolic reprogramming.
Ongoing studies investigate these topics in the context of obesity-associated inflammation/insulin resistance and breast cancer.

Other Positions

  • Member, BU-BMC Cancer Center, Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of California, San Diego, PhD
  • University of Torino, BSc

Classes Taught

  • GMSBI777

Publications

  • Published on 2/14/2022

    Cardamone MD, Gao Y, Kwan J, Hayashi V, Sheeran M, Xu J, English J, Orofino J, Emili A, Perissi V. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins. J Cell Biol. 2022 03 07; 221(3). PMID: 35157000.

    Read at: PubMed
  • Published on 1/7/2021

    Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2021 Jan 07; 81(1):212. PMID: 33417854.

    Read at: PubMed
  • Published on 1/7/2021

    Chan S, Smith E, Gao Y, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MD, Monti S, Emili A, Perissi V. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling. Front Cell Dev Biol. 2020; 8:608044. PMID: 33490071.

    Read at: PubMed
  • Published on 11/19/2020

    Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M, Perissi V, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, Mühlberger E, Emili A. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Mol Cell. 2020 12 17; 80(6):1104-1122.e9. PMID: 33259812.

    Read at: PubMed
  • Published on 8/23/2020

    English J, Son JM, Cardamone MD, Lee C, Perissi V. Decoding the rosetta stone of mitonuclear communication. Pharmacol Res. 2020 11; 161:105161. PMID: 32846213.

    Read at: PubMed
  • Published on 2/11/2020

    Jones JEC, Rabhi N, Orofino J, Gamini R, Perissi V, Vernochet C, Farmer SR. The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet. Sci Rep. 2020 02 11; 10(1):2380. PMID: 32047213.

    Read at: PubMed
  • Published on 8/10/2019

    Lima TI, Guimarães DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito Â, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori MA, Orofino J, Perissi V, Mottis A, Auwerx J, Silveira LR. Opposing action of NCoR1 and PGC-1a in mitochondrial redox homeostasis. Free Radic Biol Med. 2019 11 01; 143:203-208. PMID: 31408725.

    Read at: PubMed
  • Published on 11/21/2018

    Cardamone MD, Orofino J, Labadorf A, Perissi V. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue. J Vis Exp. 2018 11 21; (141). PMID: 30531713.

    Read at: PubMed
  • Published on 8/21/2018

    Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, Perissi V, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann Neurol. 2018 08; 84(2):289-301. PMID: 30014514.

    Read at: PubMed
  • Published on 3/1/2018

    Cardamone MD, Tanasa B, Cederquist CT, Huang J, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V. Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation. Mol Cell. 2018 03 01; 69(5):757-772.e7. PMID: 29499132.

    Read at: PubMed

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