Tsuneya Ikezu, MD, PhD

Professor, Pharmacology & Experimental Therapeutics

Tsuneya Ikezu
617.414.2658
72 E. Concord St Instructional (L)

Biography

My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer’s disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer’s disease.

Other Positions

  • Professor, Neurology, Boston University School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • Tokyo Medical and Dental University, MD
  • Tokyo Medical and Dental University, PhD
  • University of Tokyo, BS

Classes Taught

  • GMSPM843

Publications

  • Published on 4/14/2021

    Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 Apr 14; 16(1):24. PMID: 33853665.

    Read at: PubMed
  • Published on 3/22/2021

    Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Mol Neurodegener. 2021 03 22; 16(1):18. PMID: 33752701.

    Read at: PubMed
  • Published on 2/12/2021

    Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, Luebke JI, Ikezu T. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain. 2021 02 12; 144(1):288-309. PMID: 33246331.

    Read at: PubMed
  • Published on 2/3/2021

    Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res. 2021 03 05; 20(3):1733-1743. PMID: 33534581.

    Read at: PubMed
  • Published on 11/23/2020

    Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 Jun; 19(6):1017-1034. PMID: 33451707.

    Read at: PubMed
  • Published on 8/25/2020

    Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. 2020 08 25; 9(9). PMID: 32854315.

    Read at: PubMed
  • Published on 8/18/2020

    Ruan Z, Delpech JC, Venkatesan Kalavai S, Van Enoo AA, Hu J, Ikezu S, Ikezu T. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener. 2020 08 18; 15(1):47. PMID: 32811520.

    Read at: PubMed
  • Published on 4/17/2020

    Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, Gendelman HE, Issadore D, Zaia J, Ikezu T. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimers Dement. 2020 06; 16(6):896-907. PMID: 32301581.

    Read at: PubMed
  • Published on 4/15/2020

    Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Mol Cell Proteomics. 2020 06; 19(6):1017-1034. PMID: 32295833.

    Read at: PubMed
  • Published on 3/16/2020

    Ikezu T, Koro L, Wolozin B, Farraye FA, Strongosky AJ, Wszolek ZK. Crohn's and Parkinson's Disease-Associated LRRK2 Mutations Alter Type II Interferon Responses in Human CD14+ Blood Monocytes Ex Vivo. J Neuroimmune Pharmacol. 2020 12; 15(4):794-800. PMID: 32180132.

    Read at: PubMed

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