Tsuneya Ikezu, MD, PhD

Adjunct Professor, Pharmacology & Experimental Therapeutics

Tsuneya Ikezu
617.358.9565
72 E. Concord St Instructional (L)

Biography

My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer’s disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer’s disease.

Other Positions

  • Professor, Neurology, Boston University School of Medicine
  • Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • Tokyo Medical and Dental University, MD
  • Tokyo Medical and Dental University, PhD
  • University of Tokyo, BS

Publications

  • Published on 7/13/2022

    Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Publisher Correction: Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 Jul 13. PMID: 35831741.

    Read at: PubMed
  • Published on 6/10/2022

    Okusha Y, Lang BJ, Murshid A, Borges TJ, Holton KM, Clark-Matott J, Doshi S, Ikezu T, Calderwood SK. Extracellular Hsp90a stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell Stress Chaperones. 2022 Jun 10. PMID: 35689138.

    Read at: PubMed
  • Published on 5/14/2022

    You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. 2022 Jun; 21(6):e13617. PMID: 35567427.

    Read at: PubMed
  • Published on 5/10/2022

    Ruan Z, Takamatsu-Yukawa K, Wang Y, Ushman ML, Labadorf AT, Ericsson M, Ikezu S, Ikezu T. Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia. Cell Rep. 2022 May 10; 39(6):110791. PMID: 35545052.

    Read at: PubMed
  • Published on 2/9/2022

    Jun GR, You Y, Zhu C, Meng G, Chung J, Panitch R, Hu J, Xia W, Bennett DA, Foroud TM, Wang LS, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Au R, Lunetta KL, Ikezu T, Stein TD, Farrer LA. Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ?2 for Alzheimer's disease. Alzheimers Dement. 2022 Feb 09. PMID: 35142023.

    Read at: PubMed
  • Published on 1/1/2022

    You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. J Extracell Vesicles. 2022 01; 11(1):e12183. PMID: 35029059.

    Read at: PubMed
  • Published on 12/1/2021

    Hersh SW, You Y, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Alzheimers Dement. 2021 Dec; 17 Suppl 2:e058592. PMID: 34971140.

    Read at: PubMed
  • Published on 9/15/2021

    Delpech JC, Pathak D, Varghese M, Kalavai SV, Hays EC, Hof PR, Johnson WE, Ikezu S, Medalla M, Luebke JI, Ikezu T. Wolframin-1-expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice. Sci Transl Med. 2021 09 15; 13(611):eabe8455. PMID: 34524859.

    Read at: PubMed
  • Published on 9/3/2021

    Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE e2 protective effect in Alzheimer disease. Mol Psychiatry. 2021 10; 26(10):6054-6064. PMID: 34480088.

    Read at: PubMed
  • Published on 9/1/2021

    Muraoka S, DeLeo AM, Yang Z, Tatebe H, Yukawa-Takamatsu K, Ikezu S, Tokuda T, Issadore D, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Aging Dis. 2021 Sep; 12(6):1363-1375. PMID: 34527415.

    Read at: PubMed

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