Stefano Monti, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.

Dr. Monti's laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.

Publications

  • Published 3/27/2026

    Monti S, Lustgarten MS, Huang Z, Song Z, Li M, Ellis D, Tian Q, Ferrucci L, Rappaport N, Andersen SL, Perls TP, Sebastiani P. Metabolomic signatures of extreme old age: findings from the New England Centenarian Study. Geroscience. 2026 Mar 27. PMID: 41888502.

    Read at: PubMed

  • Published 3/11/2026

    Kroehling L, Chen A, Spinella A, Reed E, Kukuruzinska M, Varelas X, Monti S. A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer. Commun Med (Lond). 2026 Mar 11; 6(1). PMID: 41813916.

    Read at: PubMed

  • Published 2/21/2026

    Li M, Song Z, Reed E, Karagiannis TT, Andersen S, Brent M, Mateusiak C, Acharya S, Jung WJ, Liao S, Wojczynski MK, Feitosa MF, O'Connell JR, Montasser ME, Thorpe RJ, Arbeev K, Milman S, Tai A, Perls TT, Sebastiani P, Monti S. Whole blood transcriptional signatures of age and survival identified in long life family and integrative longevity omics studies. Geroscience. 2026 Feb 21. PMID: 41723297.

    Read at: PubMed

  • Published 2/4/2026

    Chen A, Kroehling L, Ennis CS, Denis GV, Monti S. A highly resolved integrated single-cell atlas of human breast cancers. NAR Genom Bioinform. 2026 Mar; 8(1):lqaf217. PMID: 41640877.

    Read at: PubMed

  • Published 1/16/2026

    Chakraborty AK, Kroehling L, Raut RD, Choudhury C, Kukuruzinska MA, Gutkind JS, Varelas X, Sahay B, Monti S, Bais MV. LSD1 Inhibition Induces MHC-I and Dendritic Cell Activation to Promote Antitumor Immunity in Head and Neck Squamous Cell Carcinoma. Cancer Res. 2026 Jan 16; 86(2):503-518. PMID: 41066547.

    Read at: PubMed

View All 168 Publications:   View Full Profile in BUMC

Other Positions

  • Associate Professor, Biostatistics
    Boston University School of Public Health
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Bioinformatics Graduate Program
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • University of Pittsburgh, PhD
  • University of Pittsburgh, MS
  • University of Houston, MS
  • Università degli Studi di Udine, BS

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