Stefano Monti, PhD
Professor, Medicine
Biography
Stefano Monti is a Computational Biologist and joined the BU faculty in January 2011 in the section of Computational Biomedicine, with joint appointments in the Biostatistics Department and the Bioinformatics program. Monti received his Ph.D. in Intelligent Systems and Artificial Intelligence from the University of Pittsburgh, and completed his training with a post-doctoral fellowship at the Robotics Institute at Carnegie Mellon. His doctoral and post-doctoral research focused on the development of machine learning and knowledge discovery methodologies, with a particular emphasis on probabilistic reasoning and Bayesian approaches to modeling biomedical data. Since 2001, he has worked in the field of Cancer Genomics, first as a Research Scientist at the Whitehead Institute’s Center for Genome Research, and later as a Computational Biologist in the Cancer Program at the Broad Institute.
Dr. Monti’s laboratory integrates systems biology, machine learning, and bioinformatics approaches to investigate the molecular drivers of human disease, with the goals of advancing prevention and care. This multidisciplinary effort relies on the development of novel computational methodologies, and on the design of experiments based on the generation and integrative analysis of high-throughput multi-omics data, with the goal of identifying novel therapeutic targets and developing accurate diagnostic and prognostic biomarkers. Specific areas of research include the study of the molecular mechanisms of tumor initiation and progression and of the role played in it by environmental exposure, as well as the study of the biological factors contributing to healthy aging and extreme longevity.
Other Positions
- Associate Professor, Biostatistics, Boston University School of Public Health
- Member, BU-BMC Cancer Center, Boston University
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Member, Bioinformatics Graduate Program, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- University of Pittsburgh, PhD
- University of Pittsburgh, MS
- University of Houston, MS
- Università degli Studi di Udine, BS
Publications
- Published on 3/6/2025
Qiu Y, Chen A, Yu R, Llevenes P, Seen M, Ko NY, Monti S, Denis GV. Insulin Resistance Increases TNBC Aggressiveness and Brain Metastasis via Adipocyte-derived Exosomes. Mol Cancer Res. 2025 Mar 06. PMID: 40047645.
Read at: PubMed - Published on 3/4/2025
Kroehling L, Chen A, Spinella A, Reed E, Kukuruzinka M, Varelas X, Monti S. A highly resolved integrated single-cell atlas of HPV-negative head and neck cancer. bioRxiv. 2025 Mar 04. PMID: 40093171.
Read at: PubMed - Published on 3/3/2025
Snyder M, Wang Z, Lara B, Fimbres J, Pichardo T, Mazzilli S, Khan MM, Duggineni VK, Monti S, Sherr DH. The aryl hydrocarbon receptor controls IFN-?-induced immune checkpoints PD-L1 and IDO via the JAK/STAT pathway in lung adenocarcinoma. J Immunol. 2025 Mar 03. PMID: 40073102.
Read at: PubMed - Published on 2/14/2025
Kern JG, Kroehling L, Spinella AJ, Monti S, Varelas X. LATS1/2 inactivation in the mammary epithelium drives the evolution of a tumor-associated niche. EMBO Rep. 2025 Mar; 26(6):1472-1503. PMID: 39953252.
Read at: PubMed - Published on 2/11/2025
Rogina B, Anderson R, Lebrasseur N, Curan S, Yousefzadeh MJ, Ghosh B, Duque G, Howlett S, Austad S, Demuth I, Gerstorf D, Korfhage J, Lombard DB, Abadir P, Christensen K, Carey JR, Alberts SC, Campos F, Palavicini JP, Palmer A, Bell J, Basisty N, de Cabo R, Gomes A, Dixit VD, Sen P, Baur JA, Imai SI, Li X, Valdez G, Orr ME, Pletcher S, Andersen J, Jones L, Castillo-Azofeida D, Bonaguidi M, Suh Y, Duncan FE, Murray A, Wang MC, Burkewitz K, Henne M, Zhou K, Bouhrara M, Benjamini D, Kolind S, Walker KA, Reiter DA, Dean Iii D, Gorbunova V, Gladyshev VN, Palovics R, Niedernhofer LJ, Fan R, Bueckle AD, Hurley J, Esser KA, Kapahi P, Sato S, Jiang N, Ashiqueali SA, Diaz J, Mishra SP, Ralmundo N, Banarjee R, Allsopp R, Reynolds LM, Zhang B, Sebastiani P, Monti S, Schork N, Rappaport N. Symposia Report of The Annual Biological Sciences Section Meeting of the Gerontological Society of America 2023, Tampa, Florida. J Gerontol A Biol Sci Med Sci. 2025 Feb 11. PMID: 39932386.
Read at: PubMed - Published on 11/5/2024
Sebastiani P, Monti S, Lustgarten MS, Song Z, Ellis D, Tian Q, Schwaiger-Haber M, Stancliffe E, Leshchyk A, Short MI, Ardisson Korat AV, Gurinovich A, Karagiannis T, Li M, Lords HJ, Xiang Q, Marron MM, Bae H, Feitosa MF, Wojczynski MK, O'Connell JR, Montasser ME, Schupf N, Arbeev K, Yashin A, Schork N, Christensen K, Andersen SL, Ferrucci L, Rappaport N, Perls TT, Patti GJ. Metabolite signatures of chronological age, aging, survival, and longevity. Cell Rep. 2024 Nov 26; 43(11):114913. PMID: 39504246.
Read at: PubMed - Published on 10/12/2024
Llevenes P, Chen A, Lawton M, Qiu Y, Seen M, Monti S, Denis GV. Plasma Exosomes in Insulin Resistant Obesity Exacerbate Progression of Triple Negative Breast Cancer. bioRxiv. 2024 Oct 12. PMID: 39416125.
Read at: PubMed - Published on 9/19/2024
Ennis CS, Seen M, Chen A, Kang H, Ilinski A, Mahdaviani K, Ko N, Monti S, Denis GV. Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids. bioRxiv. 2024 Sep 19. PMID: 39345362.
Read at: PubMed - Published on 8/13/2024
Snyder M, Wang Z, Lara B, Fimbres J, Pichardo T, Mazzilli S, Khan MM, Duggineni VK, Monti S, Sherr DH. The Aryl Hydrocarbon Receptor Controls IFN?-Induced Immune Checkpoints PD-L1 and IDO via the JAK/STAT Pathway in Lung Adenocarcinoma. bioRxiv. 2024 Aug 13. PMID: 39185148.
Read at: PubMed - Published on 7/25/2024
Reed ER, Chandler KB, Lopez P, Costello CE, Andersen SL, Perls TT, Li M, Bae H, Soerensen M, Monti S, Sebastiani P. Cross-platform proteomics signatures of extreme old age. Geroscience. 2025 Feb; 47(1):1199-1220. PMID: 39048883.
Read at: PubMed
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