The major focus of research in the laboratory is the study of molecular mechanisms utilized by ocular antigen presenting cells (APCs) to regulate inflammatory ocular immune responses. Particular focus is on elucidating the role of thrombospondin-1 (TSP-1) in regulating ocular inflammation.
Resident ocular APCs in the posterior and anterior segment of the eye depend on TSP-1 for maintaining an anti-inflammatory phenotype. In the absence of TSP-1 these APCs acquire more immunogenic phenotype. These observations are examined further to determine their role in ocular inflammation.
Induction of regulatory T cells (Treg) subset by ocular APCs is known to be a key component of ocular immune privilege. The ability of ocular APCs to induce Treg and its correlation with their expression of TSP-1 is examined in the laboratory at the level of molecular mechanisms.
The laboratory has identified spontaneous development of autoimmune Sjögren’s syndrome and related ocular inflammation in TSP-1 deficient mice that closely resembles clinical symptoms in human Sjögren’s patients. Different projects in the laboratory address immunologic mechanisms underlying disease development in these mice.
- Northeastern University, PhD
- Northeastern University, MS
- University of Bombay, BSc
- Published on 8/9/2017
Wakshull E, Quarmby V, Mahler HC, Rivers H, Jere D, Ramos M, Szczesny P, Bechtold-Peters K, Masli S, Gupta S. Advancements in Understanding Immunogenicity of Biotherapeutics in the Intraocular Space. AAPS J. 2017 Nov; 19(6):1656-1668. PMID: 28795351.
- Published on 1/31/2017
Contreras Ruiz L, Mir FA, Turpie B, Masli S. Thrombospondin-derived peptide attenuates Sjögren's syndrome-associated ocular surface inflammation in mice. Clin Exp Immunol. 2017 Apr; 188(1):86-95. PMID: 28033649.
- Published on 9/30/2016
Shatos MA, Hodges RR, Morinaga M, McNay DE, Islam R, Bhattacharya S, Li D, Turpie B, Makarenkova HP, Masli S, Utheim TP, Dartt DA. Alteration in cellular turnover and progenitor cell population in lacrimal glands from thrombospondin 1-/- mice, a model of dry eye. Exp Eye Res. 2016 Dec; 153:27-41. PMID: 27697548.
- Published on 2/8/2016
Smith RE, Reyes NJ, Khandelwal P, Schlereth SL, Lee HS, Masli S, Saban DR. Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease. J Leukoc Biol. 2016 Aug; 100(2):371-80. PMID: 26856994.
- Published on 10/14/2015
Contreras-Ruiz L, Mir FA, Turpie B, Krauss AH, Masli S. Sjögren's syndrome associated dry eye in a mouse model is ameliorated by topical application of integrin a4 antagonist GW559090. Exp Eye Res. 2016 Feb; 143:1-8. PMID: 26463157.
- Published on 10/12/2015
Mir FA, Contreras-Ruiz L, Masli S. Thrombospondin-1-dependent immune regulation by transforming growth factor-ß2-exposed antigen-presenting cells. Immunology. 2015 Dec; 146(4):547-56. PMID: 26458493.
- Published on 7/20/2015
Masli S. Matricellular Proteins in Ocular Diseases. J Ocul Pharmacol Ther. 2015 Sep; 31(7):365. PMID: 26192047.
- Published on 7/8/2015
Soriano-Romaní L, Contreras-Ruiz L, García-Posadas L, López-García A, Masli S, Diebold Y. Inflammatory Cytokine-Mediated Regulation of Thrombospondin-1 and CD36 in Conjunctival Cells. J Ocul Pharmacol Ther. 2015 Sep; 31(7):419-28. PMID: 26154920.
- Published on 6/1/2015
Regenfuß B, Dreisow ML, Hos D, Masli S, Bock F, Cursiefen C. The Naïve Murine Cornea as a Model System to Identify Novel Endogenous Regulators of Lymphangiogenesis: TRAIL and rtPA. Lymphat Res Biol. 2015 Jun; 13(2):76-84. PMID: 26091403.
- Published on 5/26/2015
Terzulli M, Contreras-Ruiz L, Ruiz LC, Kugadas A, Masli S, Gadjeva M. TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis. J Ocul Pharmacol Ther. 2015 Sep; 31(7):413-8. PMID: 26352162.
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