Sachiko Homma Takayama, PhD, is a Research Assistant Professor of Neurology at the Boston University School of Medicine. For her research, she has received funding from many organizations including Friends of FSH Research for researching the roles of molecular chaperones and the ubiquitin-proteasome system in skeletal muscle diseases. She has made new discoveries in the medical field including having identified a new pathway of myogenic cell death in myofibrillar myopathy.
- Otsuma Women's University, PhD
- University of Tsukuba, BS
- Published on 2/19/2019
Mitsuhashi H, Homma S, Beermann ML, Ishimaru S, Takeda H, Yu BK, Liu K, Duraiswamy S, Boyce FM, Miller JB. Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Sci Rep. 2019 Feb 19; 9(1):2274. PMID: 30783185.
- Published on 4/26/2018
Mitsuhashi H, Ishimaru S, Homma S, Yu B, Honma Y, Beermann ML, Miller JB. Functional domains of the FSHD-associated DUX4 protein. Biol Open. 2018 Apr 26; 7(4). PMID: 29618456.
- Published on 12/1/2016
Homma S, Beermann ML, Yu B, Boyce FM, Miller JB. Nuclear bodies reorganize during myogenesis in vitro and are differentially disrupted by expression of FSHD-associated DUX4. Skelet Muscle. 2016 Dec 01; 6(1):42. PMID: 27906075.
- Published on 3/29/2015
Jones TI, King OD, Himeda CL, Homma S, Chen JC, Beermann ML, Yan C, Emerson CP, Miller JB, Wagner KR, Jones PL. Individual epigenetic status of the pathogenic D4Z4 macrosatellite correlates with disease in facioscapulohumeral muscular dystrophy. Clin Epigenetics. 2015; 7(1):37. PMID: 25904990.
- Published on 1/15/2015
Homma S, Beermann ML, Boyce FM, Miller JB. Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation. Ann Clin Transl Neurol. 2015 Feb; 2(2):151-66. PMID: 25750920.
- Published on 3/17/2014
Himeda CL, Debarnot C, Homma S, Beermann ML, Miller JB, Jones PL, Jones TI. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol Cell Biol. 2014 Jun; 34(11):1942-55. PMID: 24636994.
- Published on 7/13/2012
Jones TI, Chen JC, Rahimov F, Homma S, Arashiro P, Beermann ML, King OD, Miller JB, Kunkel LM, Emerson CP, Wagner KR, Jones PL. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum Mol Genet. 2012 Oct 15; 21(20):4419-30. PMID: 22798623.
- Published on 11/23/2011
Homma S, Chen JC, Rahimov F, Beermann ML, Hanger K, Bibat GM, Wagner KR, Kunkel LM, Emerson CP, Miller JB. A unique library of myogenic cells from facioscapulohumeral muscular dystrophy subjects and unaffected relatives: family, disease and cell function. Eur J Hum Genet. 2012 Apr; 20(4):404-10. PMID: 22108603.
- Published on 4/19/2011
Homma S, Beermann ML, Miller JB. Peripheral nerve pathology, including aberrant Schwann cell differentiation, is ameliorated by doxycycline in a laminin-a2-deficient mouse model of congenital muscular dystrophy. Hum Mol Genet. 2011 Jul 1; 20(13):2662-72. PMID: 21505075.
- Published on 8/26/2010
Iwasaki M, Tanaka R, Hishiya A, Homma S, Reed JC, Takayama S. BAG3 directly associates with guanine nucleotide exchange factor of Rap1, PDZGEF2, and regulates cell adhesion. Biochem Biophys Res Commun. 2010 Sep 24; 400(3):413-8. PMID: 20800573.
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