Ruslan Afasizhev PhD, is a Professor of Molecular and Cell Biology at the Boston University Goldman School of Dental Medicine. With funding from six fellowships including those from FEBS , EMBO, and CNRS-Russian Academy of Sciences Program, he received postdoctoral training at the Howard Hughes Medical Institute of the University of California, Los Angeles. He has published over 40 papers in the field of Biology and runs a lab where he is broadly interested in molecular mechanisms of RNA processing in Trypanosoma brucei spp. He is a current member of the American Society for Microbiology and the RNA Society.
- Professor, Biochemistry, Boston University School of Medicine
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Russian Academy of Medical Sciences, PhD
- Moscow State University, MS
- Moscow State University, BA
- Published on 7/6/2017
Zhang L, Sement FM, Suematsu T, Yu T, Monti S, Huang L, Aphasizhev R, Aphasizheva I. PPR polyadenylation factor defines mitochondrial mRNA identity and stability in trypanosomes. EMBO J. 2017 Aug 15; 36(16):2435-2454. PMID: 28684539.
- Published on 10/15/2016
Rajappa-Titu L, Suematsu T, Munoz-Tello P, Long M, Demir Ö, Cheng KJ, Stagno JR, Luecke H, Amaro RE, Aphasizheva I, Aphasizhev R, Thore S. RNA Editing TUTase 1: structural foundation of substrate recognition, complex interactions and drug targeting. Nucleic Acids Res. 2016 Dec 15; 44(22):10862-10878. PMID: 27744351.
- Published on 10/7/2016
Aphasizhev R, Suematsu T, Zhang L, Aphasizheva I. Constructive edge of uridylation-induced RNA degradation. RNA Biol. 2016 Nov; 13(11):1078-1083. PMID: 27715485.
- Published on 3/25/2016
Aphasizheva I, Zhang L, Aphasizhev R. Investigating RNA editing factors from trypanosome mitochondria. Methods. 2016 Sep 01; 107:23-33. PMID: 27020893.
- Published on 1/28/2016
Suematsu T, Zhang L, Aphasizheva I, Monti S, Huang L, Wang Q, Costello CE, Aphasizhev R. Antisense Transcripts Delimit Exonucleolytic Activity of the Mitochondrial 3' Processome to Generate Guide RNAs. Mol Cell. 2016 Feb 4; 61(3):364-78. PMID: 26833087.
- Published on 1/20/2016
Aphasizheva I, Maslov DA, Qian Y, Huang L, Wang Q, Costello CE, Aphasizhev R. Ribosome-associated pentatricopeptide repeat proteins function as translational activators in mitochondria of trypanosomes. Mol Microbiol. 2016 Mar; 99(6):1043-58. PMID: 26713541.
- Published on 11/10/2015
Aphasizheva I, Aphasizhev R. U-Insertion/Deletion mRNA-Editing Holoenzyme: Definition in Sight. Trends Parasitol. 2016 Feb; 32(2):144-56. PMID: 26572691.
- Published on 10/14/2015
Wong RG, Kazane K, Maslov DA, Rogers K, Aphasizhev R, Simpson L. U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA. Mitochondrion. 2015 Nov; 25:76-86. PMID: 26462764.
- Published on 9/15/2014
Aphasizheva I, Zhang L, Wang X, Kaake RM, Huang L, Monti S, Aphasizhev R. RNA binding and core complexes constitute the U-insertion/deletion editosome. Mol Cell Biol. 2014 Dec 1; 34(23):4329-42. PMID: 25225332.
- Published on 1/17/2014
Aphasizhev R, Aphasizheva I. Mitochondrial RNA editing in trypanosomes: small RNAs in control. Biochimie. 2014 May; 100:125-31. PMID: 24440637.
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