Raphael A. Zoeller, PhD

Associate Professor, Physiology & Biophysics

Raphael Zoeller
700 Albany St Ctr for Adv Biomed Res


My expertise is in the area of lipid biosynthesis and metabolism and how they relate to human disease. My laboratory uses molecular biology, lipid chemistry & analysis, protein chemistry and forward genetics (mutant isolation).
We have recently developed a cell-based, high-throughput protocol to screen small molecule libraries for inhibitors of animal cell phospholipid biosynthesis. We have identified several candidate compounds and are now characterizing their efficacy and mode(s) of action.

Other Positions

  • Research Assistant Professor, Biomedical Genetics, Medicine, Boston University School of Medicine
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
  • Member, Boston Nutrition Obesity Research Center, Boston University


  • Texas A&M University, PhD
  • University of Maine, BS

Classes Taught

  • GMSFC703
  • GMSOH730


  • Published on 9/11/2020

    Honsho M, Tanaka M, Zoeller RA, Fujiki Y. Distinct Functions of Acyl/Alkyl Dihydroxyacetonephosphate Reductase in Peroxisomes and Endoplasmic Reticulum. Front Cell Dev Biol. 2020; 8:855. PMID: 33042986.

    Read at: PubMed
  • Published on 3/24/2020

    Werner ER, Keller MA, Sailer S, Lackner K, Koch J, Hermann M, Coassin S, Golderer G, Werner-Felmayer G, Zoeller RA, Hulo N, Berger J, Watschinger K. The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):7792-7798. PMID: 32209662.

    Read at: PubMed
  • Published on 1/3/2020

    Park H, Haller J, Smith F, Parkin N, Lythe T, Zoeller RA, Chakravorty S. Attenuation of Hemolysis Due to Glucose-6-Phosphate Isomerase Deficiency With Ketogenic Diet - A Case Report. Hemasphere. 2020 Feb; 4(1):e328. PMID: 32072144.

    Read at: PubMed
  • Published on 3/6/2019

    Zoeller RA, Geoghegan-Barek K. A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis. Biochem Biophys Rep. 2019 Jul; 18:100621. PMID: 30899803.

    Read at: PubMed
  • Published on 4/6/2018

    Jarugumilli GK, Choi JR, Chan P, Yu M, Sun Y, Chen B, Niu J, DeRan M, Zheng B, Zoeller R, Lin C, Wu X. Chemical Probe to Identify the Cellular Targets of the Reactive Lipid Metabolite 2- trans-Hexadecenal. ACS Chem Biol. 2018 05 18; 13(5):1130-1136. PMID: 29608264.

    Read at: PubMed
  • Published on 3/14/2018

    Werner ER, Keller MA, Sailer S, Seppi D, Golderer G, Werner-Felmayer G, Zoeller RA, Watschinger K. A novel assay for the introduction of the vinyl ether double bond into plasmalogens using pyrene-labeled substrates. J Lipid Res. 2018 05; 59(5):901-909. PMID: 29540573.

    Read at: PubMed
  • Published on 5/25/2012

    Nakahara K, Ohkuni A, Kitamura T, Abe K, Naganuma T, Ohno Y, Zoeller RA, Kihara A. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. Mol Cell. 2012 May 25; 46(4):461-71. PMID: 22633490.

    Read at: PubMed
  • Published on 4/6/2012

    Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE. Reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes. PLoS One. 2012; 7(4):e34904. PMID: 22493722.

    Read at: PubMed
  • Published on 7/21/2011

    Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402. PMID: 21787864.

    Read at: PubMed
  • Published on 12/17/2009

    Anbukumar DS, Shornick LP, Albert CJ, Steward MM, Zoeller RA, Neumann WL, Ford DA. Chlorinated lipid species in activated human neutrophils: lipid metabolites of 2-chlorohexadecanal. J Lipid Res. 2010 May; 51(5):1085-92. PMID: 20019386.

    Read at: PubMed

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