Rachel Fearns, PhD

Associate Professor, Microbiology

Rachel Fearns
617.358.9287
72 E. Concord St Housman (R)

Biography

Expertise in paramyxovirus genome transcription and replication mechanisms.

Other Positions

  • Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences

Education

  • University of St Andrews, PhD
  • University of Leeds, BS

Publications

  • Published on 4/8/2019

    Deflubé LR, Cressey TN, Hume AJ, Olejnik J, Haddock E, Feldmann F, Ebihara H, Fearns R, Mühlberger E. Ebolavirus polymerase uses an unconventional genome replication mechanism. Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17):8535-8543. PMID: 30962389.

    Read at: PubMed
  • Published on 2/28/2019

    Noton SL, Tremaglio CZ, Fearns R. Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication. PLoS Pathog. 2019 02; 15(2):e1007548. PMID: 30817806.

    Read at: PubMed
  • Published on 12/28/2018

    Badolo A, Burt F, Daniel S, Fearns R, Gudo ES, Kielian M, Lescar J, Shi Y, von Brunn A, Weiss SR, Hilgenfeld R. Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018. Antiviral Res. 2019 Feb; 162:142-150. PMID: 30597184.

    Read at: PubMed
  • Published on 9/11/2018

    Cox RM, Toots M, Yoon JJ, Sourimant J, Ludeke B, Fearns R, Bourque E, Patti J, Lee E, Vernachio J, Plemper RK. Development of an allosteric inhibitor class blocking RNA elongation by the respiratory syncytial virus polymerase complex. J Biol Chem. 2018 10 26; 293(43):16761-16777. PMID: 30206124.

    Read at: PubMed
  • Published on 7/27/2018

    Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R. Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter. Nucleic Acids Res. 2018 Jul 27; 46(13):6785-6796. PMID: 29873775.

    Read at: PubMed
  • Published on 7/27/2018

    Yoon JJ, Toots M, Lee S, Lee ME, Ludeke B, Luczo JM, Ganti K, Cox RM, Sticher ZM, Edpuganti V, Mitchell DG, Lockwood MA, Kolykhalov AA, Greninger AL, Moore ML, Painter GR, Lowen AC, Tompkins SM, Fearns R, Natchus MG, Plemper RK. Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses. Antimicrob Agents Chemother. 2018 Aug; 62(8). PMID: 29891600.

    Read at: PubMed
  • Published on 5/3/2018

    Atienza BJP, Jensen LD, Noton SL, Ansalem AKV, Hobman T, Fearns R, Marchant DJ, West FG. Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene-Azide Cascade Chemistry. J Org Chem. 2018 Jul 06; 83(13):6829-6842. PMID: 29663810.

    Read at: PubMed
  • Published on 12/27/2017

    Braun MR, Deflubé LR, Noton SL, Mawhorter ME, Tremaglio CZ, Fearns R. RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V. PLoS Pathog. 2017 12; 13(12):e1006803. PMID: 29281742.

    Read at: PubMed
  • Published on 1/16/2017

    Fearns R, Plemper RK. Polymerases of paramyxoviruses and pneumoviruses. Virus Res. 2017 Apr 15; 234:87-102. PMID: 28104450.

    Read at: PubMed
  • Published on 8/27/2016

    Fearns R, Deval J. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral Res. 2016 Oct; 134:63-76. PMID: 27575793.

    Read at: PubMed

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