Neil J. Ganem, PhD

Assistant Professor, Pharmacology & Experimental Therapeutics

Neil Ganem
72 E. Concord St Silvio Conte (K)


Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Other Positions

  • Assistant Professor, Hematology & Medical Oncology, Medicine, Boston University School of Medicine


  • Geisel School of Medicine, PhD
  • University of New Hampshire, BS

Classes Taught


  • Published on 4/4/2019

    Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 2019 04 04; 10(1):1547. PMID: 30948712.

    Read at: PubMed
  • Published on 1/1/2019

    Quinton RJ, Ganem NJ. CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Methods Mol Biol. 2019; 1893:203-214. PMID: 30565136.

    Read at: PubMed
  • Published on 5/23/2018

    Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Mol Biol Cell. 2018 07 15; 29(13):1682-1692. PMID: 29791254.

    Read at: PubMed
  • Published on 5/14/2018

    Bolgioni AF, Vittoria MA, Ganem NJ. Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel. J Vis Exp. 2018 05 14; (135). PMID: 29806834.

    Read at: PubMed
  • Published on 11/1/2017

    Henssen AG, Reed C, Jiang E, Garcia HD, von Stebut J, MacArthur IC, Hundsdoerfer P, Kim JH, de Stanchina E, Kuwahara Y, Hosoi H, Ganem NJ, Dela Cruz F, Kung AL, Schulte JH, Petrini JH, Kentsis A. Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med. 2017 Nov 01; 9(414). PMID: 29093183.

    Read at: PubMed
  • Published on 9/11/2017

    Grant TJ, Mehta AK, Gupta A, Sharif AAD, Arora KS, Deshpande V, Ting DT, Bardeesy N, Ganem NJ, Hergovich A, Singh A. STK38L kinase ablation promotes loss of cell viability in a subset of KRAS-dependent pancreatic cancer cell lines. Oncotarget. 2017 Oct 03; 8(45):78556-78572. PMID: 29108249.

    Read at: PubMed
  • Published on 11/1/2016

    Lim S, Quinton RJ, Ganem NJ. Nuclear envelope rupture drives genome instability in cancer. Mol Biol Cell. 2016 Nov 01; 27(21):3210-3213. PMID: 27799497.

    Read at: PubMed
  • Published on 1/1/2016

    Bolgioni AF, Ganem NJ. The interplay between centrosomes and the Hippo tumor suppressor pathway. Chromosome Res. 2016 Jan; 24(1):93-104. PMID: 26582635.

    Read at: PubMed
  • Published on 1/1/2016

    Shenk EM, Ganem NJ. Generation and Purification of Tetraploid Cells. Methods Mol Biol. 2016; 1413:393-401. PMID: 27193862.

    Read at: PubMed
  • Published on 3/18/2015

    Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F. Genomic instability: Crossing pathways at the origin of structural and numerical chromosome changes. Environ Mol Mutagen. 2015 Aug; 56(7):563-80. PMID: 25784636.

    Read at: PubMed

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