Neil J. Ganem, PhD
Associate Professor, Pharmacology, Physiology & Biophysics
Biography
Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.
Other Positions
- Associate Professor, Hematology & Medical Oncology, Medicine, Boston University Chobanian & Avedisian School of Medicine
- Member, BU-BMC Cancer Center, Boston University
- Member, Genome Science Institute, Boston University
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Education
- Geisel School of Medicine, PhD
- University of New Hampshire, BS
Publications
- Published on 7/15/2022
Darp R, Vittoria MA, Ganem NJ, Ceol CJ. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nat Commun. 2022 Jul 15; 13(1):4109. PMID: 35840569.
Read at: PubMed - Published on 6/29/2022
Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022 Jun 29; 13(1):3732. PMID: 35768444.
Read at: PubMed - Published on 9/20/2021
Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443. PMID: 34365507.
Read at: PubMed - Published on 5/1/2021
Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Publisher Correction: Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 May; 593(7860):E15. PMID: 33976417.
Read at: PubMed - Published on 1/27/2021
Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 02; 590(7846):492-497. PMID: 33505027.
Read at: PubMed - Published on 2/3/2020
Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256. PMID: 32015438.
Read at: PubMed - Published on 4/4/2019
Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 2019 04 04; 10(1):1547. PMID: 30948712.
Read at: PubMed - Published on 1/1/2019
Quinton RJ, Ganem NJ. CRISPR-Mediated Approaches to Regulate YAP/TAZ Levels. Methods Mol Biol. 2019; 1893:203-214. PMID: 30565136.
Read at: PubMed - Published on 5/23/2018
Vittoria MA, Shenk EM, O'Rourke KP, Bolgioni AF, Lim S, Kacprzak V, Quinton RJ, Ganem NJ. A genome-wide microRNA screen identifies regulators of tetraploid cell proliferation. Mol Biol Cell. 2018 07 15; 29(13):1682-1692. PMID: 29791254.
Read at: PubMed - Published on 5/14/2018
Bolgioni AF, Vittoria MA, Ganem NJ. Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel. J Vis Exp. 2018 05 14; (135). PMID: 29806834.
Read at: PubMed
View 21 more publications: View full profile at BUMC