Neil J. Ganem, PhD

Associate Professor, Pharmacology, Physiology & Biophysics

Neil Ganem
617.358.4678
72 E. Concord St Silvio Conte (K)

Biography

Dr. Ganem’s laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, cell biology, and bioinformatics to study the causes and consequences of genome instability in human cancer. Dr. Ganem’s lab seeks to define the tumor suppression mechanisms that limit the proliferation of highly abnormal aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.

Other Positions

  • Associate Professor, Hematology & Medical Oncology, Medicine, Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center, Boston University
  • Member, Genome Science Institute, Boston University
  • Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Education

  • Geisel School of Medicine, PhD
  • University of New Hampshire, BS

Publications

  • Published on 9/14/2023

    Vittoria MA, Quinton RJ, Ganem NJ. Whole-genome doubling in tissues and tumors. Trends Genet. 2023 Dec; 39(12):954-967. PMID: 37714734.

    Read at: PubMed
  • Published on 6/15/2023

    Vedula CP, Ganem NJ. CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes. Mol Cell. 2023 Jun 15; 83(12):1964-1966. PMID: 37327773.

    Read at: PubMed
  • Published on 3/23/2023

    Laroche FJF, Li S, Shen N, Hwang SK, Nguyen G, Yu W, Wong CK, Quinton RJ, Berman JN, Liu CT, Singh A, Ganem NJ, Thiagalingam S, Feng H. S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 2023 Mar 23; 12(7). PMID: 37048053.

    Read at: PubMed
  • Published on 7/15/2022

    Darp R, Vittoria MA, Ganem NJ, Ceol CJ. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nat Commun. 2022 Jul 15; 13(1):4109. PMID: 35840569.

    Read at: PubMed
  • Published on 6/29/2022

    Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nat Commun. 2022 Jun 29; 13(1):3732. PMID: 35768444.

    Read at: PubMed
  • Published on 9/20/2021

    Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, Flynn RL. SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. Nucleic Acids Res. 2021 09 20; 49(16):9424-9443. PMID: 34365507.

    Read at: PubMed
  • Published on 5/1/2021

    Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Publisher Correction: Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 May; 593(7860):E15. PMID: 33976417.

    Read at: PubMed
  • Published on 1/27/2021

    Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Whole-genome doubling confers unique genetic vulnerabilities on tumour cells. Nature. 2021 02; 590(7846):492-497. PMID: 33505027.

    Read at: PubMed
  • Published on 2/3/2020

    Gan W, Dai X, Dai X, Xie J, Yin S, Zhu J, Wang C, Liu Y, Guo J, Wang M, Liu J, Hu J, Quinton RJ, Ganem NJ, Liu P, Asara JM, Pandolfi PP, Yang Y, He Z, Gao G, Wei W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 02; 22(2):246-256. PMID: 32015438.

    Read at: PubMed
  • Published on 4/4/2019

    Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nat Commun. 2019 04 04; 10(1):1547. PMID: 30948712.

    Read at: PubMed

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