Michael J. Rynkiewicz

Instructor, Physiology & Biophysics

Michael Rynkiewicz
617.358.8482
700 Albany St Ctr for Adv Biomed Res

Biography

I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.

Education

  • Boston University School of Medicine, PhD
  • Massachusetts Institute of Technology, BS

Publications

  • Published on 8/18/2018

    Lehman W, Li X, Kiani FA, Moore JR, Campbell SG, Fischer S, Rynkiewicz MJ. Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. Biophys J. 2018 Sep 18; 115(6):1082-1092. PMID: 30195938.

    Read at: PubMed
  • Published on 5/16/2018

    van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 Jul 06; 293(27):10646-10662. PMID: 29769321.

    Read at: PubMed
  • Published on 4/5/2018

    Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked a-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018 Jun 01; 647:84-92. PMID: 29626422.

    Read at: PubMed
  • Published on 12/5/2017

    Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J. 2017 Dec 05; 113(11):2444-2451. PMID: 29211998.

    Read at: PubMed
  • Published on 9/12/2017

    Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, Katz J, Lehman W, Cammarato A. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Rep. 2017 Sep 12; 20(11):2612-2625. PMID: 28903042.

    Read at: PubMed
  • Published on 7/31/2017

    Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. 2017 Aug 08; 56(31):4095-4105. PMID: 28719181.

    Read at: PubMed
  • Published on 9/20/2016

    Rynkiewicz MJ, Fischer S, Lehman W. The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys. 2016 Nov 01; 609:51-58. PMID: 27663225.

    Read at: PubMed
  • Published on 6/21/2016

    Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 05; 55(26):3692-701. PMID: 27324153.

    Read at: PubMed
  • Published on 1/14/2016

    Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan; 3(1):012002. PMID: 26798831.

    Read at: PubMed
  • Published on 8/26/2015

    Tripathi S, Wang G, White M, Rynkiewicz M, Seaton B, Hartshorn K. Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis. PLoS One. 2015; 10(8):e0133454. PMID: 26308522.

    Read at: PubMed

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