Michael J. Rynkiewicz, PhD

Instructor, Physiology & Biophysics

Michael Rynkiewicz
617.358.8482
700 Albany St Ctr for Adv Biomed Res

Biography

I am a protein crystallographer with extensive experience in computational structural analysis. My work over the years has encompassed a broad range of techniques, including protein crystallography, kinetic assays, organic synthesis, NMR and ultraviolet spectroscopy, small molecule structure-based drug design, epitope mapping of antibodies, and molecular dynamics calculations.

Education

  • Boston University School of Medicine, PhD
  • Massachusetts Institute of Technology, BS

Classes Taught

  • GMSBY762
  • GMSOH730
  • GMSPH730

Publications

  • Published on 5/14/2022

    Pavadai E, Rynkiewicz MJ, Yang Z, Gould IR, Marston SB, Lehman W. Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation. Arch Biochem Biophys. 2022 May 14; 725:109282. PMID: 35577070.

    Read at: PubMed
  • Published on 2/15/2022

    Teekakirikul P, Zhu W, Xu X, Young CB, Tan T, Smith AM, Wang C, Peterson KA, Gabriel GC, Ho S, Sheng Y, Moreau de Bellaing A, Sonnenberg DA, Lin JH, Fotiou E, Tenin G, Wang MX, Wu YL, Feinstein T, Devine W, Gou H, Bais AS, Glennon BJ, Zahid M, Wong TC, Ahmad F, Rynkiewicz MJ, Lehman WJ, Keavney B, Alastalo TP, Freckmann ML, Orwig K, Murray S, Ware SM, Zhao H, Feingold B, Lo CW. Genetic resiliency associated with dominant lethal TPM1 mutation causing atrial septal defect with high heritability. Cell Rep Med. 2022 02 15; 3(2):100501. PMID: 35243414.

    Read at: PubMed
  • Published on 7/28/2021

    Sewanan LR, Park J, Rynkiewicz MJ, Racca AW, Papoutsidakis N, Schwan J, Jacoby DL, Moore JR, Lehman W, Qyang Y, Campbell SG. Loss of crossbridge inhibition drives pathological cardiac hypertrophy in patients harboring the TPM1 E192K mutation. J Gen Physiol. 2021 09 06; 153(9). PMID: 34319370.

    Read at: PubMed
  • Published on 3/11/2021

    Lehman W, Pavadai E, Rynkiewicz MJ. C-terminal troponin-I residues trap tropomyosin in the muscle thin filament blocked-state. Biochem Biophys Res Commun. 2021 04 30; 551:27-32. PMID: 33714756.

    Read at: PubMed
  • Published on 12/11/2020

    Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end. J Biol Chem. 2020 Dec 11; 295(50):17128-17137. PMID: 33453963.

    Read at: PubMed
  • Published on 10/5/2020

    Racca AW, Rynkiewicz MJ, LaFave N, Ghosh A, Lehman W, Moore JR. M8R tropomyosin mutation disrupts actin binding and filament regulation: The beginning affects the middle and end. J Biol Chem. 2020 12 11; 295(50):17128-17137. PMID: 33020181.

    Read at: PubMed
  • Published on 7/16/2020

    Doran MH, Pavadai E, Rynkiewicz MJ, Walklate J, Bullitt E, Moore JR, Regnier M, Geeves MA, Lehman W. Cryo-EM and Molecular Docking Shows Myosin Loop 4 Contacts Actin and Tropomyosin on Thin Filaments. Biophys J. 2020 08 18; 119(4):821-830. PMID: 32730789.

    Read at: PubMed
  • Published on 5/22/2020

    Pavadai E, Lehman W, Rynkiewicz MJ. Protein-Protein Docking Reveals Dynamic Interactions of Tropomyosin on Actin Filaments. Biophys J. 2020 07 07; 119(1):75-86. PMID: 32521240.

    Read at: PubMed
  • Published on 5/15/2020

    Viswanathan MC, Schmidt W, Franz P, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nat Commun. 2020 05 15; 11(1):2417. PMID: 32415060.

    Read at: PubMed
  • Published on 12/14/2019

    Sundar S, Rynkiewicz MJ, Ghosh A, Lehman W, Moore JR. Cardiomyopathy Mutation Alters End-to-End Junction of Tropomyosin and Reduces Calcium Sensitivity. Biophys J. 2020 01 21; 118(2):303-312. PMID: 31882250.

    Read at: PubMed

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