Melisa Ruiz-Gutierrez, MD, PhD

Assistant Professor, Pediatrics

Melisa Ruiz-Gutierrez
771 Albany Street


Melisa Ruiz-Gutierrez, MD, PhD is an Assistant Professor of Pediatrics at the Boston University School of Medicine. Before arriving at the university, Dr. Ruiz-Gutierrez was an Instructor at Harvard Medical School. Throughout her career, she has served as a research assistant and associate for organizations in the Boston and Seattle area. Dr. Ruiz-Gutierrez has lectured on the TGFb pathway, Shwachman Diamond Syndrome, and bone marrow failure.

Other Positions

  • Member, Center of Excellence in Sickle Cell Disease, Boston University School of Medicine


  • Mount Sinai School of Medicine, MD
  • Mount Sinai School of Medicine, PhD
  • Smith College, BS


  • Published on 4/7/2022

    Perez-Atayde AR, Debelenko L, Al-Ibraheemi A, Eng W, Ruiz-Gutierrez M, O'Hare M, Croteau SE, Trenor CC, Boyer D, Balkin DM, Barclay SF, Hsi Dickie B, Liang MG, Chaudry G, Alomari AI, Mulliken JB, Adams DM, Kurek KC, Fishman SJ, Kozakewich HPW. Kaposiform Lymphangiomatosis: Pathologic Aspects in 43 Patients. Am J Surg Pathol. 2022 Apr 07. PMID: 35385405.

    Read at: PubMed
  • Published on 4/1/2022

    Alomari MH, Shahin MM, Fishman SJ, Kerr CL, Smith ER, Eng W, Ruiz-Gutierrez M, Adams DM, Orbach DB, Chaudry G, Shaikh R, Chewning R, Alomari AI. Cerebrospinal fluid leak in epidural venous malformations and blue rubber bleb nevus syndrome. J Neurosurg Spine. 2022 Apr 01; 1-7. PMID: 35364593.

    Read at: PubMed
  • Published on 6/18/2019

    Joyce CE, Saadatpour A, Ruiz-Gutierrez M, Bolukbasi OV, Jiang L, Thomas DD, Young S, Hofmann I, Sieff CA, Myers KC, Whangbo J, Libermann TA, Nusbaum C, Yuan GC, Shimamura A, Novina CD. TGFß signaling underlies hematopoietic dysfunction and bone marrow failure in Shwachman-Diamond Syndrome. J Clin Invest. 2019 06 18; 129(9):3821-3826. PMID: 31211692.

    Read at: PubMed
  • Published on 4/30/2019

    Ruiz-Gutierrez M, Bölükbasi ÖV, Alexe G, Kotini AG, Ballotti K, Joyce CE, Russell DW, Stegmaier K, Myers K, Novina CD, Papapetrou EP, Shimamura A. Therapeutic discovery for marrow failure with MDS predisposition using pluripotent stem cells. JCI Insight. 2019 04 30; 5. PMID: 31039138.

    Read at: PubMed
  • Published on 1/12/2017

    Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M, Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A. The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma. Leuk Res. 2017 04; 55:23-32. PMID: 28119225.

    Read at: PubMed
  • Published on 10/30/2006

    Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL. eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol. 2006 Nov 06; 175(3):415-26. PMID: 17074885.

    Read at: PubMed
  • Published on 4/18/2005

    Culjkovic B, Topisirovic I, Skrabanek L, Ruiz-Gutierrez M, Borden KL. eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR. J Cell Biol. 2005 Apr 25; 169(2):245-56. PMID: 15837800.

    Read at: PubMed
  • Published on 12/1/2004

    Topisirovic I, Ruiz-Gutierrez M, Borden KL. Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res. 2004 Dec 01; 64(23):8639-42. PMID: 15574771.

    Read at: PubMed
  • Published on 10/24/2000

    Hirschhorn JN, Sklar P, Lindblad-Toh K, Lim YM, Ruiz-Gutierrez M, Bolk S, Langhorst B, Schaffner S, Winchester E, Lander ES. SBE-TAGS: an array-based method for efficient single-nucleotide polymorphism genotyping. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12164-9. PMID: 11035790.

    Read at: PubMed
  • Published on 9/15/2000

    Shapiro R, Ruiz-Gutierrez M, Chen CZ. Analysis of the interactions of human ribonuclease inhibitor with angiogenin and ribonuclease A by mutagenesis: importance of inhibitor residues inside versus outside the C-terminal "hot spot". J Mol Biol. 2000 Sep 15; 302(2):497-519. PMID: 10970748.

    Read at: PubMed

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