Mark W. Grinstaff, PhD

Professor, Chemistry

Mark Grinstaff
(617) 358-3429
590 Commonwealth Ave

Biography

Mark W. Grinstaff is a Distinguished Professor of Translational Research, Biomedical Engineering, Chemistry, Materials Science and Engineering, and Medicine as well as the Director of the NIH T32 Program in Biomaterials and the Director of the Nanotechnology Innovation Center at Boston University.

Mark received his Ph.D. from the University of Illinois under the mentorship of Professor Kenneth S. Suslick and was an NIH postdoctoral fellow at the California Institute of Technology with Professor Harry B. Gray. Mark’s awards include the ACS Nobel Laureate Signature Award, NSF Career Award, Pew Scholar in the Biomedical Sciences, Camille Dreyfus Teacher- Scholar, Alfred P. Sloan Research Fellowship, the Edward M. Kennedy Award for Health Care Innovation, and a Founding Fellow of the National Academy of Inventors. He is an author or co-author on more than 225 peer-reviewed manuscripts, given more than 300 oral presentations, and an inventor or co- inventor on more than 200 issued patents or pending applications. His students and fellows have given more than 125 oral presentations and 350 posters at national and international meetings.

Mark’s current research activities involve the synthesis of new macromolecules and biomaterials, self-assembly chemistry, imaging contrast agents, drug delivery, and wound repair. His group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. The major goal in these research projects is to elucidate the underlying fundamental chemistry and engineering principles and to use that insight to direct our creative and scientific efforts. In one of their current research projects, they are designing, synthesizing, and characterizing novel dendrimers, termed “biodendrimers,” for tissue engineering and biotechnological applications. Currently, they are evaluating these novel biomaterials for the repair of corneal lacerations, for the delivery of anti-cancer drugs, for the delivery of DNA, and as temporary biodegradable scaffolds for cartilage repair. In a second project, they are creating novel polymeric coatings termed “interfacial biomaterials” that control biology on plastic, metal, and ceramic surfaces. In a third project, they are designing new polymeric films and nanoparticles loaded with anticancer drugs for the prevention of recurrent cancer after surgical resection.

Mark is a co-founder of several companies that are commercializing his ideas, and he has several products being sold and used in the clinic.

Other Positions

  • Director, Nanotechnology Innovation Center (BUnano), Boston University
  • Professor, Biomedical Engineering, Boston University College of Engineering
  • Professor, Pulmonary, Allergy, Sleep & Critical Care Medicine, Medicine, Boston University School of Medicine

Education

  • University of Illinois, PhD
  • Occidental College, AB

Publications

  • Published on 9/27/2017

    Xiao R, Dane EL, Zeng J, McKnight CJ, Grinstaff MW. Synthesis of Altrose Poly-amido-saccharides with ß-N-(1?2)-d-amide Linkages: A Right-Handed Helical Conformation Engineered in at the Monomer Level. J Am Chem Soc. 2017 Oct 11; 139(40):14217-14223. PMID: 28902504.

    Read at: PubMed
  • Published on 9/4/2017

    Reynolds DS, Tevis KM, Blessing WA, Colson YL, Zaman MH, Grinstaff MW. Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment. Sci Rep. 2017 Sep 04; 7(1):10382. PMID: 28871147.

    Read at: PubMed
  • Published on 6/27/2017

    Stewart RC, Patwa AN, Lusic H, Freedman JD, Wathier M, Snyder BD, Guermazi A, Grinstaff MW. Synthesis and Preclinical Characterization of a Cationic Iodinated Imaging Contrast Agent (CA4+) and Its Use for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage. J Med Chem. 2017 Jul 13; 60(13):5543-5555. PMID: 28616978.

    Read at: PubMed
  • Published on 5/22/2017

    Nelson BB, Goodrich LR, Barrett MF, Grinstaff MW, Kawcak CE. Use of contrast media in computed tomography and magnetic resonance imaging in horses: Techniques, adverse events and opportunities. Equine Vet J. 2017 Jul; 49(4):410-424. PMID: 28407291.

    Read at: PubMed
  • Published on 5/19/2017

    Jain A, Khalid M, Qureshi MM, Georgian-Smith D, Kaplan JA, Buch K, Grinstaff MW, Hirsch AE, Hines NL, Anderson SW, Gallagher KM, Bates DDB, Bloch BN. Stereotactic core needle breast biopsy marker migration: An analysis of factors contributing to immediate marker migration. Eur Radiol. 2017 Nov; 27(11):4797-4803. PMID: 28526892.

    Read at: PubMed
  • Published on 5/4/2017

    Mashiatulla M, Moran MM, Chan D, Li J, Freedman JD, Snyder BD, Grinstaff MW, Plaas A, Sumner DR. Murine articular cartilage morphology and compositional quantification with high resolution cationic contrast-enhanced µCT. J Orthop Res. 2017 May 04. PMID: 28471533.

    Read at: PubMed
  • Published on 4/11/2017

    Oh DJ, Lakin BA, Stewart RC, Wiewiorski M, Freedman JD, Grinstaff MW, Snyder BD. Contrast-enhanced CT imaging as a non-destructive tool for ex vivo examination of the biochemical content and structure of the human meniscus. J Orthop Res. 2017 May; 35(5):1018-1028. PMID: 27302693.

    Read at: PubMed
  • Published on 3/9/2017

    Cooper BG, Lawson TB, Snyder BD, Grinstaff MW. Reinforcement of articular cartilage with a tissue-interpenetrating polymer network reduces friction and modulates interstitial fluid load support. Osteoarthritis Cartilage. 2017 Jul; 25(7):1143-1149. PMID: 28285000.

    Read at: PubMed
  • Published on 2/9/2017

    Colby AH, Oberlies NH, Pearce CJ, Herrera VL, Colson YL, Grinstaff MW. Nanoparticle drug-delivery systems for peritoneal cancers: a case study of the design, characterization and development of the expansile nanoparticle. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 May; 9(3). PMID: 28185434.

    Read at: PubMed
  • Published on 2/7/2017

    Konieczynska MD, Grinstaff MW. On-Demand Dissolution of Chemically Cross-Linked Hydrogels. Acc Chem Res. 2017 Feb 21; 50(2):151-160. PMID: 28170219.

    Read at: PubMed

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