Maria Trojanowska, PhD

Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Dr. Trojanowska’s research is aimed at understanding the molecular and cellular mechanisms that regulate ECM synthesis in healthy tissues and in pathological conditions such as fibrosis and tumorigenesis. The majority of her studies focus on the pathogenesis of scleroderma, an autoimmune disease characterized by vascular abnormalities and a prominent fibrosis of the skin. Her laboratory uses molecular and cellular approaches and various experimental models to elucidate the mechanisms responsible for uncontrolled ECM deposition and vessel degeneration in scleroderma. The second area of investigation is related to activation of tumor stroma. These studies examine the molecular mechanisms that mediate controlled regulation of ECM turnover in healthy connective tissue and are responsible for dysregulation of this process during tumorigenesis. Recent studies together with Dr. Lafyatis are examining the role of ER stress in systemic sclerosis.

Publications

  • Published 1/26/2026

    Distler JHW, Launay D, Feghali-Bostwick C, Matei AE, Trojanowska M, Gudjonsson JE. Mechanisms of fibrotic tissue remodelling: insights from systemic sclerosis. Nat Rev Rheumatol. 2026 Apr; 22(4):221-238. PMID: 41588245.

    Read at: PubMed

  • Published 12/11/2025

    Dambal V, Zaia I, Goncharov D, Dey T, Zhyvylo I, Goncharova EA, Trojanowska M. Endothelial GATA6 deficiency suppresses intracellular TLR3-interferon signaling in HPAECs and promotes interferon response in HPASMCs. bioRxiv. 2025 Dec 11. PMID: 41427363.

    Read at: PubMed

  • Published 7/25/2025

    Dinc MT, El-Adili F, Lui JK, Kripesh S, York M, Trojanowski M, Ligresti G, Lafyatis R, Trojanowska M, Bujor AM. Transcriptomic profiling of scleroderma monocytes reveals links with cardiovascular complications, implicating Notch and interferon pathways. J Scleroderma Relat Disord. 2025 Jul 25; 23971983251356123. PMID: 40735732.

    Read at: PubMed

  • Published 4/1/2025

    Abraham DJ, Black CM, Denton CP, Distler JHW, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F, Kuwana M, Lafyatis R, Landegren U, Mahoney JM, Martin J, Matucci-Cerinic M, McMahan ZH, Mora AL, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield ML, Gabrielli A, Krieg T. Publisher Correction: An international perspective on the future of systemic sclerosis research. Nat Rev Rheumatol. 2025 Apr; 21(4):249. PMID: 40032952.

    Read at: PubMed

  • Published 2/14/2025

    Abraham DJ, Black CM, Denton CP, Distler JHW, Domsic R, Feghali-Bostwick C, Gourh P, Hinchcliff M, Kolling F, Kuwana M, Lafyatis R, Landegren U, Mahoney JM, Martin J, Matucci-Cerinic M, McMahan ZH, Mora AL, Mouthon L, Rabinovitch M, Rojas M, Rubin K, Trojanowska M, Varga J, Whitfield ML, Gabrielli A, Krieg T. An international perspective on the future of systemic sclerosis research. Nat Rev Rheumatol. 2025 Mar; 21(3):174-187. PMID: 39953141.

    Read at: PubMed

View All 191 Publications:   View Full Profile in BUMC

Other Positions

  • Director , Arthritis & Autoimmune Diseases Research Center
    Boston University Chobanian & Avedisian School of Medicine
  • Member, BU-BMC Cancer Center
    Boston University
  • Member, Pulmonary Center
    Boston University
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University
  • Member, Genome Science Institute
    Boston University
  • Graduate Medical Sciences Educator and Mentor (Primary Mentor of Graduate Students)
    Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Websites

Education

  • Polish Academy of Sciences, PhD
  • University of Warsaw, MSc

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