The work in our laboratory is focused on understanding the response of the vertebrate eye to and recovery from the effects of bright light. Our principal approach is to make electrophysiological measurements of rod and cone photoreceptors of cold-blooded vertebrate animals, and to correlate these physiological responses to microspectrophotomeric measurements of the visual pigments as well as microfluorometric measurements of the concentration of vitamin A and Ca2+ contained within the cells. The reduction of all–trans retinal to Vitamin A is one of the principal initial steps that must occur following exposure to bright light to allow recovery of sensitivity (dark adaptation). Experiments have also shown that Ca2+ is a principal messenger substance during bright (bleaching) adaptation.
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- University of Utah, PhD
- University of Utah, BS
- Published on 2/22/2019
Yue WWS, Silverman D, Ren X, Frederiksen R, Sakai K, Yamashita T, Shichida Y, Cornwall MC, Chen J, Yau KW. Elementary response triggered by transducin in retinal rods. Proc Natl Acad Sci U S A. 2019 Mar 12; 116(11):5144-5153. PMID: 30796193.
- Published on 7/5/2017
Morshedian A, Toomey MB, Pollock GE, Frederiksen R, Enright JM, McCormick SD, Cornwall MC, Fain GL, Corbo JC. Cambrian origin of the CYP27C1-mediated vitamin A1-to-A2 switch, a key mechanism of vertebrate sensory plasticity. R Soc Open Sci. 2017 Jul; 4(7):170362. PMID: 28791166.
- Published on 3/22/2017
Pahlberg J, Frederiksen R, Pollock GE, Miyagishima KJ, Sampath AP, Cornwall MC. Voltage-sensitive conductances increase the sensitivity of rod photoresponses following pigment bleaching. J Physiol. 2017 Jun 01; 595(11):3459-3469. PMID: 28168711.
- Published on 2/10/2017
Yue WW, Frederiksen R, Ren X, Luo DG, Yamashita T, Shichida Y, Cornwall MC, Yau KW. Spontaneous activation of visual pigments in relation to openness/closedness of chromophore-binding pocket. Elife. 2017 Feb 10; 6. PMID: 28186874.
- Published on 1/1/2017
Sato S, Frederiksen R, Cornwall MC, Kefalov VJ. The retina visual cycle is driven by cis retinol oxidation in the outer segments of cones. Vis Neurosci. 2017 Jan; 34:E004. PMID: 28359344.
- Published on 7/12/2016
Toomey MB, Lind O, Frederiksen R, Curley RW, Riedl KM, Wilby D, Schwartz SJ, Witt CC, Harrison EH, Roberts NW, Vorobyev M, McGraw KJ, Cornwall MC, Kelber A, Corbo JC. Complementary shifts in photoreceptor spectral tuning unlock the full adaptive potential of ultraviolet vision in birds. Elife. 2016 Jul 12; 5. PMID: 27402384.
- Published on 7/1/2016
Frederiksen R, Nymark S, Kolesnikov AV, Berry JD, Adler L, Koutalos Y, Kefalov VJ, Cornwall MC. Rhodopsin kinase and arrestin binding control the decay of photoactivated rhodopsin and dark adaptation of mouse rods. J Gen Physiol. 2016 Jul; 148(1):1-11. PMID: 27353443.
- Published on 10/6/2015
Wilby D, Toomey MB, Olsson P, Frederiksen R, Cornwall MC, Oulton R, Kelber A, Corbo JC, Roberts NW. Optics of cone photoreceptors in the chicken (Gallus gallus domesticus). J R Soc Interface. 2015 Oct 6; 12(111):20150591. PMID: 26423439.
- Published on 10/6/2015
Toomey MB, Collins AM, Frederiksen R, Cornwall MC, Timlin JA, Corbo JC. A complex carotenoid palette tunes avian colour vision. J R Soc Interface. 2015 Oct 6; 12(111):20150563. PMID: 26446559.
- Published on 11/1/2014
Frederiksen R, Boyer NP, Nickle B, Chakrabarti KS, Koutalos Y, Crouch RK, Oprian D, Cornwall MC. Low aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods. J Gen Physiol. 2014 Nov; 144(5):487. PMID: 25348415.
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