Dr. Lee Goldstein received a bachelor’s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women’s Hospital, Boston. Dr. Goldstein joined the Boston University School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007. Most notably, in 2018 Dr. Goldstein’s study in the journal Brain identified evidence of early CTE brain pathology after head impact—even in the absence of signs of concussion, providing the best evidence to date that head impact, not concussion, causes CTE.
Dr. Goldstein’s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.
Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.
- Associate Professor, Neurology, Boston University School of Medicine
- Associate Professor, Pathology & Laboratory Medicine, Boston University School of Medicine
- Associate Professor, Ophthalmology, Boston University School of Medicine
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Director, Molecular Aging & Development Laboratory, Boston University School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Yale University School of Medicine, MD
- Yale University, PhD
- Columbia University, BA
- Published on 4/7/2021
Mez J, Alosco ML, Daneshvar DH, Saltiel N, Baucom Z, Abdolmohammadi B, Uretsky M, Nicks R, Martin BM, Palmisano JN, Nowinski CJ, Montenigro P, Solomon TM, Mahar I, Cherry JD, Alvarez VE, Dwyer B, Goldstein LE, Katz DI, Cantu RC, Kowall NW, Tripodis Y, Huber BR, Stein TD, Stern RA, McKee AC. Validity of the 2014 traumatic encephalopathy syndrome criteria for CTE pathology. Alzheimers Dement. 2021 Apr 07. PMID: 33826224.
- Published on 1/4/2021
Tenovuo O, Diaz-Arrastia R, Goldstein LE, Sharp DJ, van der Naalt J, Zasler ND. Assessing the Severity of Traumatic Brain Injury-Time for a Change? J Clin Med. 2021 Jan 04; 10(1). PMID: 33406786.
- Published on 9/17/2020
Adams JW, Alosco ML, Mez J, Alvarez VE, Huber BR, Tripodis Y, Adler CH, Kubilius C, Cormier KA, Mathais R, Nicks R, Kelley HJ, Saltiel N, Uretsky M, Nair E, Aytan N, Cherry JD, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Association of probable REM sleep behavior disorder with pathology and years of contact sports play in chronic traumatic encephalopathy. Acta Neuropathol. 2020 12; 140(6):851-862. PMID: 32939646.
- Published on 9/16/2020
Minaeva O, Sarangi S, Ledoux DM, Moncaster JA, Parsons DS, Washicosky KJ, Black CA, Weng FJ, Ericsson M, Moir RD, Tripodis Y, Clark JI, Tanzi RE, Hunter DG, Goldstein LE. In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans. J Gerontol A Biol Sci Med Sci. 2020 09 16; 75(9):e53-e62. PMID: 32515825.
- Published on 8/11/2020
Alosco ML, Cherry JD, Huber BR, Tripodis Y, Baucom Z, Kowall NW, Saltiel N, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Palmisano JN, Martin B, Cantu RC, Stern RA, Alvarez VE, Mez J, Stein TD, McKee AC. Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme. Acta Neuropathol. 2020 10; 140(4):495-512. PMID: 32778942.
- Published on 7/16/2020
Cherry JD, Babcock KJ, Goldstein LE. Repetitive Head Trauma Induces Chronic Traumatic Encephalopathy by Multiple Mechanisms. Semin Neurol. 2020 08; 40(4):430-438. PMID: 32674181.
- Published on 6/1/2020
Veksler R, Vazana U, Serlin Y, Prager O, Ofer J, Shemen N, Fisher AM, Minaeva O, Hua N, Saar-Ashkenazy R, Benou I, Riklin-Raviv T, Parker E, Mumby G, Kamintsky L, Beyea S, Bowen CV, Shelef I, O'Keeffe E, Campbell M, Kaufer D, Goldstein LE, Friedman A. Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players. Brain. 2020 06 01; 143(6):1826-1842. PMID: 32464655.
- Published on 5/29/2020
Sugarman MA, Zetterberg H, Blennow K, Tripodis Y, McKee AC, Stein TD, Martin B, Palmisano JN, Steinberg EG, Simkin I, Budson AE, Killiany R, O'Connor MK, Au R, Qiu WWQ, Goldstein LE, Kowall NW, Mez J, Stern RA, Alosco ML. A longitudinal examination of plasma neurofilament light and total tau for the clinical detection and monitoring of Alzheimer's disease. Neurobiol Aging. 2020 10; 94:60-70. PMID: 32585491.
- Published on 3/27/2020
Li M, Reisman J, Morris-Eppolito B, Qian SX, Kazis LE, Wolozin B, Goldstein LE, Xia W. Beneficial association of angiotensin-converting enzyme inhibitors and statins on the occurrence of possible Alzheimer's disease after traumatic brain injury. Alzheimers Res Ther. 2020 03 27; 12(1):33. PMID: 32220235.
- Published on 11/26/2019
Minaeva O, Hua N, Franz ES, Lupoli N, Mian AZ, Farris CW, Hildebrandt AM, Kiernan PT, Evers LE, Griffin AD, Liu X, Chancellor SE, Babcock KJ, Moncaster JA, Jara H, Alvarez VE, Huber BR, Guermazi A, Latour LL, McKee AC, Soto JA, Anderson SW, Goldstein LE. Nonhomogeneous Gadolinium Retention in the Cerebral Cortex after Intravenous Administration of Gadolinium-based Contrast Agent in Rats and Humans. Radiology. 2020 02; 294(2):377-385. PMID: 31769744.
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