Lee E. Goldstein, MD, PhD
Associate Professor, Psychiatry
Biography
Background
Dr. Lee Goldstein received a bachelor’s degree in humanities and biology from Columbia University and went on to complete his medical and doctoral training at Yale University. Dr. Goldstein completed an internal medicine internship and residency program in psychiatry at Harvard Medical School. He was previously an Assistant Professor of Psychiatry at Harvard Medical School, as well as the Director of the Molecular Aging & Development Laboratory and Center for Biometals & Metallomics at the Brigham & Women’s Hospital, Boston. Dr. Goldstein joined the Chobanian and Avedisian School of Medicine, College of Engineering, Photonics Center, and the BU ADC in December 2007. Most notably, in 2018 Dr. Goldstein’s study in the journal Brain identified evidence of early CTE brain pathology after head impact—even in the absence of signs of concussion, providing the best evidence to date that head impact, not concussion, causes CTE.
Research Interests
Dr. Goldstein’s work is focused on understanding the role of abnormal protein aggregation in chronic degenerative disorders of aging. The work in his laboratory concentrates on Alzheimer’s disease, age-related cataracts, and other common diseases of aging that involve pathogenic protein aggregation. His team recently discovered the first evidence of Alzheimer’s disease-associated amyloid pathology outside the brain as well as a new transcription factor that plays a crucial role in cellular differentiation within the lens and brain. He and his laboratory are developing a laser-based diagnostic technology that will hopefully detect Alzheimer’s disease years before the first symptoms emerge.
Awards/Memberships
Dr. Goldstein has received honors from numerous organizations, including the Harvard Medical School, National Institute of Mental Health, National Alliance for Research on Schizophrenia and Affective Diseases, Alzheimer’s Association, the American Psychiatric Association, and the Optical Society of America. He is a Diplomate of the American Academy of Neurology and Psychiatry.
Other Positions
- Associate Professor, Neurology, Boston University Chobanian & Avedisian School of Medicine
- Associate Professor, Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine
- Associate Professor, Ophthalmology, Boston University Chobanian & Avedisian School of Medicine
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Director, Molecular Aging & Development Laboratory, Boston University Chobanian & Avedisian School of Medicine
- Graduate Faculty (Primary Mentor of Grad Students), Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Websites
Education
- Yale University School of Medicine, MD
- Yale University, PhD
- Columbia University, BA
Publications
- Published on 3/6/2025
Emrani S, Koutures A, Tripodis Y, Uretsky M, Abdolmohammadi B, Nowinski C, Daneshvar DH, Dwyer B, Katz DI, Goldstein LE, Cantu RC, Martin BM, Palmisano JN, Dams-O'Connor K, Crary JF, Stern RA, Mez J, Alvarez VE, Huber BR, McKee AC, Stein TD, Alosco ML. Characterizing white matter and vascular pathologies in brain donors exposed to repetitive head impacts. Acta Neuropathol. 2025 Mar 06; 149(1):24. PMID: 40047953.
Read at: PubMed - Published on 12/2/2024
Abdolmohammadi B, Tuz-Zahra F, Uretsky M, Nicks R, Mosaheb S, Labonte J, Yhang E, Durape S, Martin B, Palmisano J, Nowinski C, Cherry JD, Alvarez VE, Huber BR, Dams-O'Connor K, Crary J, Dwyer B, Daneshvar DH, Goldstein LE, Au R, Katz DI, Kowall NW, Cantu RC, Stern RA, Alosco ML, Stein TD, Tripodis Y, McKee AC, Mez J. Duration of Ice Hockey Play and Chronic Traumatic Encephalopathy. JAMA Netw Open. 2024 Dec 02; 7(12):e2449106. PMID: 39630446.
Read at: PubMed - Published on 11/27/2024
Uretsky M, Nair E, Burton R, Cronin SW, Rousseau D, Tuz-Zahra F, Durape S, Abdolmohammadi B, Baucom Z, Saltiel N, Shah A, Martin B, Palmisano J, Cherry JD, Daneshvar D, Dwyer B, Dams-O'Connor K, Crary J, Goldstein L, Huber B, Katz D, Kowall N, Cantu RC, Alvarez VE, Stern RA, Stein TD, Tripodis Y, McKee AC, Alosco ML, Mez J. Chronic Traumatic Encephalopathy, Family History of Mental Illness, and Aggression in Brain Donors With Repetitive Head Impact Exposure. Neurology. 2024 Dec 24; 103(12):e210056. PMID: 39602665.
Read at: PubMed - Published on 9/1/2024
Adams JW, Kirsch D, Calderazzo SM, Tuz-Zahra F, Tripodis Y, Mez J, Alosco ML, Alvarez VE, Huber BR, Kubilus C, Cormier KA, Nicks R, Uretsky M, Nair E, Kuzyk E, Aytan N, Cherry JD, Crary JF, Daneshvar DH, Nowinski CJ, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, McKee AC, Stein TD. Substantia Nigra Pathology, Contact Sports Play, and Parkinsonism in Chronic Traumatic Encephalopathy. JAMA Neurol. 2024 Sep 01; 81(9):916-924. PMID: 39008284.
Read at: PubMed - Published on 6/17/2024
Abdennadher M, Jacobellis S, Václavu L, Juttukonda M, Inati S, Goldstein L, van Osch MJP, Rosen B, Hua N, Theodore W. Water exchange across the blood-brain barrier and epilepsy: Review on pathophysiology and neuroimaging. Epilepsia Open. 2024 Aug; 9(4):1123-1135. PMID: 38884502.
Read at: PubMed - Published on 4/15/2024
Culhane JE, Jackson CE, Tripodis Y, Nowinski CJ, Dams-O'Connor K, Pettway E, Uretsky M, Abdolmohammadi B, Nair E, Martin B, Palmisano J, Katz DI, Dwyer B, Daneshvar DH, Goldstein LE, Kowall NW, Cantu RC, Stern RA, Huber BR, Crary JF, Mez J, Stein TD, McKee AC, Alosco ML. Lack of Association of Informant-Reported Traumatic Brain Injury and Chronic Traumatic Encephalopathy. J Neurotrauma. 2024 Jun; 41(11-12):1399-1408. PMID: 38445389.
Read at: PubMed - Published on 2/26/2024
Alexander A, Alvarez VE, Huber BR, Alosco ML, Mez J, Tripodis Y, Nicks R, Katz DI, Dwyer B, Daneshvar DH, Martin B, Palmisano J, Goldstein LE, Crary JF, Nowinski C, Cantu RC, Kowall NW, Stern RA, Delalle I, McKee AC, Stein TD. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta Neuropathol. 2024 Feb 26; 147(1):45. PMID: 38407651.
Read at: PubMed - Published on 2/6/2024
Alosco ML, White M, Bell C, Faheem F, Tripodis Y, Yhang E, Baucom Z, Martin B, Palmisano J, Dams-O'Connor K, Crary JF, Goldstein LE, Katz DI, Dwyer B, Daneshvar DH, Nowinski C, Cantu RC, Kowall NW, Stern RA, Alvarez VE, Huber BR, Stein TD, McKee AC, Mez J. Cognitive, functional, and neuropsychiatric correlates of regional tau pathology in autopsy-confirmed chronic traumatic encephalopathy. Mol Neurodegener. 2024 Feb 06; 19(1):10. PMID: 38317248.
Read at: PubMed - Published on 2/2/2024
Sarangi S, Minaeva O, Ledoux DM, Parsons DS, Moncaster JA, Black CA, Hollander J, Tripodis Y, Clark JI, Hunter DG, Goldstein LE. In vivo quasi-elastic light scattering detects molecular changes in the lenses of adolescents with Down syndrome. Exp Eye Res. 2024 Apr; 241:109818. PMID: 38422787.
Read at: PubMed - Published on 1/1/2024
Walsh M, Uretsky M, Tripodis Y, Nowinski CJ, Rasch A, Bruce H, Ryder M, Martin BM, Palmisano JN, Katz DI, Dwyer B, Daneshvar DH, Walley AY, Kim TW, Goldstein LE, Stern RA, Alvarez VE, Huber BR, McKee AC, Stein TD, Mez J, Alosco ML. Clinical and Neuropathological Correlates of Substance Use in American Football Players. J Alzheimers Dis. 2024; 101(3):971-986. PMID: 39269838.
Read at: PubMed
View 76 more publications: View full profile at BUMC