Our research principally deals with innate immunity, which refers to immune responses that are hard-wired into the genome and provide a first line of protection against infection or transformed cells. Innate immune responses are sometimes also responsible for damaging inflammation. Defects or variants in innate immunity account for increased propensity for infections or harmful inflammation. As an example, people lacking one of the collectins found in blood are at greater risk for infection during neutropenia and have a greater risk for certain cancers. There is surprising complexity and specificity to innate immunity despite the fact that it provides protection even when a person has not been exposed to a specific infection. The main aspects of innate immunity we study include neutrophils and monocyte/macrophages, toll like receptors, and soluble immune defense proteins called collectins and defensins. We study how neutrophils and monocytes become activated in response to infectious organisms (viruses and bacteria), including studies of cell signaling, phagocytosis and oxidant production. We study how defensins and collectins kill bacteria or viruses and promote their uptake by neutrophils and monocytes. We have created or collaborate to create and test a variety of new recombinant versions of collectins and defensins, some of which have strongly increased antiviral or antibacterial activity. We also collaborate with members of the department of Biophysics in crystallographic studies of collectin structure in order to predict protein changes that might confer greater antimicrobial activity. We also collaborate in use of mouse models (e.g., mice in which collectin genes are deleted) to study the role of specific innate immune mediators in infection. A particular area of interest for us is the innate immune response to respiratory infection, especially influenza virus infection. Influenza virus and HIV (which we also study to some extent) are important examples of infections for which innate immunity is important since these viruses undergo continuous mutation thus evading adaptive immune responses (i.e., specific T and B cell responses).
- Graduate Faculty (Primary Mentor of Grad Students), Boston University School of Medicine, Graduate Medical Sciences
- Active Staff Privileges, Hematology & Medical Oncology, Medicine, Boston Medical Center
- Albert Einstein College of Medicine, MD
- Williams College, MA
- Williams College, BA
- Published on 11/20/2018
Sheikh AR, Yameen H, Hartshorn K. Treatment of Rectal Cancer in Older Adults. Curr Oncol Rep. 2018 Nov 20; 20(12):102. PMID: 30456634.
- Published on 10/24/2018
Elias R, Hartshorn K, Rahma O, Lin N, Snyder-Cappione JE. Aging,?immune senescence,?and immunotherapy:?A comprehensive review. Semin Oncol. 2018 08; 45(4):187-200. PMID: 30539714.
- Published on 9/12/2018
Shin TH, Inagaki E, Ganta T, Hartshorn K, Litle VR, Suzuki K. Tumor Lysis Syndrome After Bilobectomy for Typical Carcinoid Tumor of the Lung. Ann Thorac Surg. 2019 Mar; 107(3):e199-e201. PMID: 30218665.
- Published on 7/17/2018
Kumaradevan S, Lee SY, Richards S, Lyle C, Zhao Q, Tapan U, Jiangliu Y, Ghumman S, Walker J, Belghasem M, Arinze N, Kuhnen A, Weinberg J, Francis J, Hartshorn K, Kolachalama VB, Cifuentes D, Rahimi N, Chitalia VC. c-Cbl Expression Correlates with Human Colorectal Cancer Survival and Its Wnt/ß-Catenin Suppressor Function Is Regulated by Tyr371 Phosphorylation. Am J Pathol. 2018 Aug; 188(8):1921-1933. PMID: 30029779.
- Published on 6/13/2018
Hsieh IN, De Luna X, White MR, Hartshorn KL. The Role and Molecular Mechanism of Action of Surfactant Protein D in Innate Host Defense Against Influenza A Virus. Front Immunol. 2018; 9:1368. PMID: 29951070.
- Published on 5/16/2018
van Eijk M, Rynkiewicz MJ, Khatri K, Leymarie N, Zaia J, White MR, Hartshorn KL, Cafarella TR, van Die I, Hessing M, Seaton BA, Haagsman HP. Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus. J Biol Chem. 2018 07 06; 293(27):10646-10662. PMID: 29769321.
- Published on 3/16/2018
White MR, Kandel R, Hsieh IN, De Luna X, Hartshorn KL. Critical role of C-terminal residues of the Alzheimer's associated ß-amyloid protein in mediating antiviral activity and modulating viral and bacterial interactions with neutrophils. PLoS One. 2018; 13(3):e0194001. PMID: 29547627.
- Published on 7/24/2017
Nikolaidis NM, Noel JG, Pitstick LB, Gardner JC, Uehara Y, Wu H, Saito A, Lewnard KE, Liu H, White MR, Hartshorn KL, McCormack FX. Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6613-E6622. PMID: 28739896.
- Published on 5/21/2017
Tapan U, Lee SY, Weinberg J, Kolachalama VB, Francis J, Charlot M, Hartshorn K, Chitalia V. Racial differences in colorectal cancer survival at a safety net hospital. Cancer Epidemiol. 2017 08; 49:30-37. PMID: 28538169.
- Published on 2/21/2017
De Luna X, Hartshorn KL. Influenza Casts a Lung Shadow. Am J Pathol. 2017 Apr; 187(4):697-699. PMID: 28222276.
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