As a clinical cardiac surgeon, I am frequently confronted with the problems of revascularization of the ischemic heart. Coronary artery bypass grafting is often employed to deliver new blood supply to the myocardium, but occasionally the anastomoses fail because of the development of neointimal hyperplasia and fibrosis where vessel connections are constructed. Using nanotechnology to deliver agents to the site of the anastomoses could be a game changer in terms of graft patency.
Transmyocardial laser revascularization of the heart has been shown to trigger neovascularization in underperfused regions of the myocardium not amenable to standard revascularization. The prospect of using nanotechnology to deliver growth factor or other agents in a targeted fashion to the area of the laser channels may help to achieve a quantum increase in the benefit realized from the laser surgery.
- Emeritus Assistant Professor, Cardiothoracic Surgery, Surgery, Boston University School of Medicine
- Member, Evans Center for Interdisciplinary Biomedical Research, Boston University
- Brown University School of Medicine, MD
- Brown University, MMS
- Brown University, AB
- Published on 12/22/2020
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Berger RL, Dunton RF, Leonardi HK, Karlson KJ. Pack and close approach to persistent postcardiopulmonary bypass bleeding. J Am Coll Surg. 1994 Apr; 178(4):353-6. PMID: 8149034.
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Berger RL, Karlson KJ, Dunton RF, Leonardi HK. Replacement of the thoracic aorta with intraluminal sutureless prosthesis. Ann Thorac Surg. 1992 May; 53(5):920-7. PMID: 1571002.
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