Junghee Lee, PhD

Research Assistant Professor, Neurology

Junghee Lee
150 S Huntington Avenue


Dr. Junghee Lee received her PhD in Neuroimmunology from Kangwon National University. She had a predoctoral fellowship at Dana-Farber Cancer Institute and completed a postdoctoral research fellowship at the Department of Neurology at Beth Israel Deaconess Medical Center and Harvard Medical School in 2004. She joined Boston University School of Medicine’s Department of Neurology in 2005 as an Assistant Research Professor. Now she is an investigator at the Boston University Alzheimer’s Disease Center and VA Boston Healthcare System. She works on the mechanisms of neuroinflammation in brain disorders. She has published over 55 original research papers.


  • Kangwon National University, PhD
  • Kangwon National University, MS
  • Kangwon National University, BS


  • Published on 6/26/2019

    Kim YH, Shim HS, Kim KH, Lee J, Chung BC, Kowall NW, Ryu H, Lee J. Metabolomic Analysis Identifies Alterations of Amino Acid Metabolome Signatures in the Postmortem Brain of Alzheimer's Disease. Exp Neurobiol. 2019 Jun; 28(3):376-389. PMID: 31308797.

    Read at: PubMed
  • Published on 4/26/2018

    Yoon Y, Park H, Kim S, Nguyen PT, Hyeon SJ, Chung S, Im H, Lee J, Lee SB, Ryu H. Genetic Ablation of EWS RNA Binding Protein 1 (EWSR1) Leads to Neuroanatomical Changes and Motor Dysfunction in Mice. Exp Neurobiol. 2018 Apr; 27(2):103-111. PMID: 29731676.

    Read at: PubMed
  • Published on 11/11/2017

    Lee J, Kim Y, Liu T, Hwang YJ, Hyeon SJ, Im H, Lee K, Alvarez VE, McKee AC, Um SJ, Hur M, Mook-Jung I, Kowall NW, Ryu H. SIRT3 deregulation is linked to mitochondrial dysfunction in Alzheimer's disease. Aging Cell. 2018 02; 17(1). PMID: 29130578.

    Read at: PubMed
  • Published on 7/26/2017

    Park KS, Kim MK, Seo Y, Ha T, Yoo K, Hyeon SJ, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Difluoroboron ß-Diketonate Probe Shows "Turn-on" Near-Infrared Fluorescence Specific for Tau Fibrils. ACS Chem Neurosci. 2017 Oct 18; 8(10):2124-2131. PMID: 28737890.

    Read at: PubMed
  • Published on 6/7/2017

    Lee J, Hwang YJ, Kim Y, Lee MY, Hyeon SJ, Lee S, Kim DH, Jang SJ, Im H, Min SJ, Choo H, Pae AN, Kim DJ, Cho KS, Kowall NW, Ryu H. Remodeling of heterochromatin structure slows neuropathological progression and prolongs survival in an animal model of Huntington's disease. Acta Neuropathol. 2017 Nov; 134(5):729-748. PMID: 28593442.

    Read at: PubMed
  • Published on 5/19/2017

    Seo JS, Lee S, Shin JY, Hwang YJ, Cho H, Yoo SK, Kim Y, Lim S, Kim YK, Hwang EM, Kim SH, Kim CH, Hyeon SJ, Yun JY, Kim J, Kim Y, Alvarez VE, Stein TD, Lee J, Kim DJ, Kim JI, Kowall NW, Ryu H, McKee AC. Transcriptome analyses of chronic traumatic encephalopathy show alterations in protein phosphatase expression associated with tauopathy. Exp Mol Med. 2017 05 19; 49(5):e333. PMID: 28524178.

    Read at: PubMed
  • Published on 10/20/2016

    Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H. Astrocytes and Microglia as Non-cell Autonomous Players in the Pathogenesis of ALS. Exp Neurobiol. 2016 Oct; 25(5):233-240. PMID: 27790057.

    Read at: PubMed
  • Published on 9/1/2016

    Seo Y, Park KS, Ha T, Kim MK, Hwang YJ, Lee J, Ryu H, Choo H, Chong Y. A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer's Disease. ACS Chem Neurosci. 2016 Nov 16; 7(11):1474-1481. PMID: 27576176.

    Read at: PubMed
  • Published on 8/12/2016

    Lee CJ, Ahn H, Lee SB, Shin JY, Park WY, Kim JI, Lee J, Ryu H, Kim S. Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice. BMC Med Genomics. 2016 Aug 12; 9 Suppl 1:33. PMID: 27534535.

    Read at: PubMed
  • Published on 7/1/2015

    Kim Y, Lee J, Ryu H. Modulation of autophagy by miRNAs. BMB Rep. 2015 Jul; 48(7):371-2. PMID: 26129673.

    Read at: PubMed

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