Joseph Kaserman, MD

Instructor, Medicine

Joseph Kaserman
72 East Concord Street, R-304

Biography

Alpha1 antitrypsin deficiency is the most common cause of hereditary liver disease, however, only about 10% of patients with the mutation develop liver disease. The mechanism for why certain patients develop liver disease remains poorly understood. Using hiPS cells we will correct the Z AAT mutation using the CRISPR/Cas9 system to compare syngeneic daughter clones. This will reduce variation due to other genetic differences allowing for a more precise evaluation of the effects from the mutant protein and allow for the creation of a disease signature.

Education

  • University of Vermont College of Medicine, MD

Publications

  • Published on 6/5/2018

    Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in a1-antitrypsin deficiency. J Hepatol. 2018 Oct; 69(4):851-860. PMID: 29879455.

    Read at: PubMed
  • Published on 1/1/2017

    Kaserman JE, Wilson AA. Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage. Methods Mol Biol. 2017; 1639:151-160. PMID: 28752455.

    Read at: PubMed
  • Published on 12/20/2006

    Garcia MI, Kaserman J, Chung YH, Jung JU, Lee SH. Herpesvirus saimiri STP-A oncoprotein utilizes Src family protein tyrosine kinase and tumor necrosis factor receptor-associated factors to elicit cellular signal transduction. J Virol. 2007 Mar; 81(6):2663-74. PMID: 17182673.

    Read at: PubMed

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