Dr. Mez completed his undergraduate studies at Cornell University and earned his medical degree from the University of Maryland School of Medicine. He completed residency training in Neurology at Massachusetts General and Brigham and Women’s Hospitals. He completed a clinical fellowship in Aging and Dementia and a research fellowship in Neuroepidemiology at Columbia University. During fellowship training, he also earned a Masters in Biostatistics with a focus on Statistical Genetics from the Mailman School of Public Health at Columbia. In 2013, he became an Assistant Professor of Neurology at Boston University (BU) School of Medicine. In 2014, he became Associate Director of the BU Alzheimer’s Disease Center (ADC) Clinical Core.
Dr. Mez’s research seeks to understand genetic, neuropathological, epidemiological and clinical aspects of various forms of dementia. He is the recipient of a K-23 Mentored Patient Oriented Career Development Award that investigates the role of genetic and non-genetic factors in atypical clinical presentations of Alzheimer’s disease. Since 2014, he led the clinical arm of the Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) study, a U01 project examining the neuropathology and clinical symptoms of brain donors who have experienced repetitive head impacts, including investigating clinicopathological correlation in chronic traumatic encephalopathy (CTE). He also is interested in how the interaction of genetic risk factors and trauma influence dementia risk, particularly chronic traumatic encephalopathy. He also is a Framingham Heart Study (FHS) investigator, leads FHS traumatic brain injury (TBI)-related projects and is involved with reaching consensus dementia diagnoses for FHS participants.
Awards and Memberships
Dr. Mez is a 2015 Spivack Neuroscience Scholar and a recipient of the 2018 Carlos S. Kase Outstanding Contribution to Neurology Research Award. He is a recipient of a Peer Reviewed Alzheimer’s Research Project Grant from the Department of Defense, a K23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Aging, a New Investigator Research Grant from the Alzheimer’s Association, a BU ADC Pilot Grant, a BU Clinical and Translational Science Institute Pilot Grant and the NIH Loan Repayment Program. He is a member of the American Academy of Neurology, the American Society of Human Genetics, the International Society to Advance Alzheimer’s Research and Treatment and the Society for Behavioral and Cognitive Neurology
- University of Maryland School of Medicine, MD
- Columbia University School of Public Health, MS
- Cornell University, BS
- Published on 12/4/2018
Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB, Crane PK. Genetic data and cognitively defined late-onset Alzheimer's disease subgroups. Mol Psychiatry. 2018 Dec 04. PMID: 30514930.
- Published on 11/4/2018
Cherry JD, Mez J, Crary JF, Tripodis Y, Alvarez VE, Mahar I, Huber BR, Alosco ML, Nicks R, Abdolmohammadi B, Kiernan PT, Evers L, Svirsky S, Babcock K, Gardner HM, Meng G, Nowinski CJ, Martin BM, Dwyer B, Kowall NW, Cantu RC, Goldstein LE, Katz DI, Stern RA, Farrer LA, McKee AC, Stein TD. Variation in TMEM106B in chronic traumatic encephalopathy. Acta Neuropathol Commun. 2018 Nov 04; 6(1):115. PMID: 30390709.
- Published on 9/1/2018
Adams JW, Alvarez VE, Mez J, Huber BR, Tripodis Y, Xia W, Meng G, Kubilus CA, Cormier K, Kiernan PT, Daneshvar DH, Chua AS, Svirsky S, Nicks R, Abdolmohammadi B, Evers L, Solomon TM, Cherry JD, Aytan N, Mahar I, Devine S, Auerbach S, Alosco ML, Nowinski CJ, Kowall NW, Goldstein LE, Dwyer B, Katz DI, Cantu RC, Stern RA, Au R, McKee AC, Stein TD. Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports. J Neuropathol Exp Neurol. 2018 Sep 01; 77(9):757-768. PMID: 30053297.
- Published on 7/23/2018
Alosco ML, Tripodis Y, Fritts NG, Heslegrave A, Baugh CM, Conneely S, Mariani M, Martin BM, Frank S, Mez J, Stein TD, Cantu RC, McKee AC, Shaw LM, Trojanowski JQ, Blennow K, Zetterberg H, Stern RA. Cerebrospinal fluid tau, Aß, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration. Alzheimers Dement. 2018 Sep; 14(9):1159-1170. PMID: 30049650.
- Published on 5/1/2018
Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901. PMID: 29710395.
- Published on 2/20/2018
Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Jun GR, Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimers Res Ther. 2018 Feb 20; 10(1):22. PMID: 29458411.
- Published on 1/1/2018
Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360. PMID: 29843242.
- Published on 12/20/2017
Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, Lunetta KL, Farrer LA, Jun GR. Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages. Alzheimers Dement. 2018 May; 14(5):623-633. PMID: 29274321.
- Published on 12/19/2017
McKee AC, Mez J, Abdolmohammadi B. Chronic Traumatic Encephalopathy in Football Players-Reply. JAMA. 2017 12 19; 318(23):2353. PMID: 29260223.
- Published on 9/26/2017
Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC. CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. PLoS One. 2017; 12(9):e0185541. PMID: 28950005.
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