Jesse B. Mez, MD

Assistant Professor, Neurology

617.414.8384
72 E. Concord St Robinson (B)

Biography

Dr. Mez completed his undergraduate studies at Cornell University and earned his medical degree from the University of Maryland School of Medicine. He completed residency training in Neurology at Massachusetts General and Brigham and Women’s Hospitals. He completed a clinical fellowship in Aging and Dementia and a research fellowship in Neuroepidemiology at Columbia University. During fellowship training, he also earned a Masters in Biostatistics with a focus on Statistical Genetics from the Mailman School of Public Health at Columbia. In 2013, he became an Assistant Professor of Neurology at Boston University School of Medicine.

Research Interests
Dr. Mez’s research focuses on the application of statistical genetics and genetic epidemiology to various forms of dementia. He is particularly interested in the role of genetic and non-genetic factors in atypical clinical presentations of Alzheimer’s disease. He also is interested in how the interaction of genetic risk factors and trauma influence dementia risk, particularly chronic traumatic encephalopathy. He leads the clinical arm of Ann McKee’s UNITE study. He is mentored by Dr. Lindsay Farrer, head of the Biomedical Genetics Division in the Department of Medicine and works closely with division members.

ADC Role
Dr. Mez is Associate Director of the ADC’s Clinical Core. He helps make clinical consensus diagnoses for ADC participants. He also provides clinical evaluations for ADC clinical trials.

Awards and Memberships
Dr. Mez is a 2015 Spivack Neuroscience Scholar. He is a recipient of a K23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Aging. He received the 2013-2014 BU ADC Pilot Grant. He is a recipient of the NIH Loan Repayment Program. He is a member of the American Academy of Neurology, the American Society of Human Genetics, the International Society to Advance Alzheimer’s Research and Treatment and the Society for Behavioral and Cognitive Neurology

Websites

Education

  • University of Maryland School of Medicine, MD
  • Columbia University School of Public Health, MS
  • Cornell University, BS

Publications

  • Published on 5/1/2018

    Alosco ML, Mez J, Tripodis Y, Kiernan PT, Abdolmohammadi B, Murphy L, Kowall NW, Stein TD, Huber BR, Goldstein LE, Cantu RC, Katz DI, Chaisson CE, Martin B, Solomon TM, McClean MD, Daneshvar DH, Nowinski CJ, Stern RA, McKee AC. Age of first exposure to tackle football and chronic traumatic encephalopathy. Ann Neurol. 2018 May; 83(5):886-901. PMID: 29710395.

    Read at: PubMed
  • Published on 2/20/2018

    Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Jun GR, Farrer LA. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimers Res Ther. 2018 Feb 20; 10(1):22. PMID: 29458411.

    Read at: PubMed
  • Published on 1/1/2018

    Alosco ML, Sugarman MA, Besser LM, Tripodis Y, Martin B, Palmisano JN, Kowall NW, Au R, Mez J, DeCarli C, Stein TD, McKee AC, Killiany RJ, Stern RA. A Clinicopathological Investigation of White Matter Hyperintensities and Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2018; 63(4):1347-1360. PMID: 29843242.

    Read at: PubMed
  • Published on 12/20/2017

    Chung J, Wang X, Maruyama T, Ma Y, Zhang X, Mez J, Sherva R, Takeyama H, Lunetta KL, Farrer LA, Jun GR. Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages. Alzheimers Dement. 2018 May; 14(5):623-633. PMID: 29274321.

    Read at: PubMed
  • Published on 12/19/2017

    McKee AC, Mez J, Abdolmohammadi B. Chronic Traumatic Encephalopathy in Football Players-Reply. JAMA. 2017 12 19; 318(23):2353. PMID: 29260223.

    Read at: PubMed
  • Published on 9/26/2017

    Cherry JD, Stein TD, Tripodis Y, Alvarez VE, Huber BR, Au R, Kiernan PT, Daneshvar DH, Mez J, Solomon TM, Alosco ML, McKee AC. CCL11 is increased in the CNS in chronic traumatic encephalopathy but not in Alzheimer's disease. PLoS One. 2017; 12(9):e0185541. PMID: 28950005.

    Read at: PubMed
  • Published on 9/19/2017

    Alosco ML, Kasimis AB, Stamm JM, Chua AS, Baugh CM, Daneshvar DH, Robbins CA, Mariani M, Hayden J, Conneely S, Au R, Torres A, McClean MD, McKee AC, Cantu RC, Mez J, Nowinski CJ, Martin BM, Chaisson CE, Tripodis Y, Stern RA. Age of first exposure to American football and long-term neuropsychiatric and cognitive outcomes. Transl Psychiatry. 2017 Sep 19; 7(9):e1236. PMID: 28926003.

    Read at: PubMed
  • Published on 8/14/2017

    Mez J, Marden JR, Mukherjee S, Walter S, Gibbons LE, Gross AL, Zahodne LB, Gilsanz P, Brewster P, Nho K, Crane PK, Larson EB, Glymour MM. Alzheimer's disease genetic risk variants beyond APOE e4 predict mortality. Alzheimers Dement (Amst). 2017; 8:188-195. PMID: 28983503.

    Read at: PubMed
  • Published on 7/25/2017

    Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR, Alosco ML, Solomon TM, Nowinski CJ, McHale L, Cormier KA, Kubilus CA, Martin BM, Murphy L, Baugh CM, Montenigro PH, Chaisson CE, Tripodis Y, Kowall NW, Weuve J, McClean MD, Cantu RC, Goldstein LE, Katz DI, Stern RA, Stein TD, McKee AC. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA. 2017 Jul 25; 318(4):360-370. PMID: 28742910.

    Read at: PubMed
  • Published on 6/15/2017

    Crane PK, Trittschuh E, Mukherjee S, Saykin AJ, Sanders RE, Larson EB, McCurry SM, McCormick W, Bowen JD, Grabowski T, Moore M, Bauman J, Gross AL, Keene CD, Bird TD, Gibbons LE, Mez J. Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study. Alzheimers Dement. 2017 Dec; 13(12):1307-1316. PMID: 28623677.

    Read at: PubMed

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