Jesse B. Mez, MD

Associate Professor, Boston University Chobanian & Avedisian School of Medicine

Biography

Jesse Mez, MD, MS, is an Associate Professor of Neurology at Boston University (BU) Chobanian & Avedisian School of Medicine. A neurologist with clinical training in aging and dementia and research training in biostatistics/statistical genetics and epidemiology, he is the Associate Director of the BU Alzheimer’s Disease Research Center (ADRC), Co-Director of Clinical Research of the BU Chronic Traumatic Encephalopathy (CTE) Center and co-leads the Framingham Heart Study Brain Aging Program Clinical Core. He is also an AD Genetic Consortium and AD Sequencing Project Investigator. His research seeks to understand the genetic, neuropathological, epidemiological, and clinical aspects of AD, CTE, and related dementias. He is an internationally recognized expert on CTE, having been a lead or co-author on several of the most highly cited manuscripts and an invited lecturer in national and international venues on the topic. Ongoing research themes include 1) the relationship between traumatic brain injury, exposure to repetitive head impacts from contact sports and military service, and dementia-related outcomes and their interaction with genetic factors, 2) clinicopathologic correlation in CTE with the goal to accurately diagnose CTE in life, 3) genetic architecture, neuropathology and clinical course of AD subtypes, as defined by variation in neuropsychological presentation and 4) interaction between genetic and environmental factors and risk for and resilience from AD. He is a Principal Investigator or Core/Project Leader, on six NIH and DOD-funded grants and is an author of more than 150 research articles, reviews, editorials, and book chapters. He also cares for patients with AD and related dementias, including those at risk for CTE in the BU/Boston Medical Center Memory and Aging Clinic.

He received his AB from Cornell University in Mathematics, his MD from the University of Maryland School of Medicine, and his MS in Biostatistics with an emphasis on Statistical Genetics from the Columbia University Mailman School of Public Health. He completed his Neurology Residency at the Harvard Mass General Brigham Program in Boston. This was followed by a Clinical Fellowship in Aging and Dementia and a Research Fellowship in Neuroepidemiology at Columbia University College of Physicians and Surgeons.

Publications

  • Published 7/11/2026

    Mulayi SC, Aaronson A, Goostrey KJ, Tuz-Zahra F, Tripodis Y, Cole-French WS, Roebuck M, Schneider G, Pine BN, Palmisano JN, Martin BM, Zavitz KH, Katz DI, Nowinski CJ, McKee AC, Stein TD, Mackin RS, McClean MD, Weuve J, Mez J, Weiner MW, Nosheny RL, Alosco ML, Stern RA. Cognitive and Behavioral Functioning in Female Former Soccer Players: Results from the Head Impact and Trauma Surveillance Study (HITSS). medRxiv. 2026 Jul 11. PMID: 42465948.

    Read at: PubMed

  • Published 7/1/2026

    Yang Y, Lorenz A, Sathe A, Schilling KG, Gaynor LS, Choi SE, Lee ML, Scollard P, Trittschuh EH, Mukherjee S, Mez J, Dumitrescu LC, Landman BA, Crane PK, Cuccaro ML, Hohman TJ, Archer DB. Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease. Alzheimers Dement. 2026 Jul; 22(7):e71663. PMID: 42427161.

    Read at: PubMed

  • Published 7/1/2026

    Miner AE, Zetterberg H, Blennow K, Groh JR, Singh A, Dieckhoff K, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Peskind E, Asken BM, Tanner JA, Rabinovici GD, Banks SJ, Barr WB, Wethe JV, Cantu RC, Dodick DW, Mez J, Palmisano JN, Martin B, Stein TD, McKee AC, Cummings JL, Shenton ME, Reiman EM, Stern RA, Ashton NJ, Alosco ML. Plasma Phosphorylated Tau 217 in Participants at Risk for Chronic Traumatic Encephalopathy. JAMA Netw Open. 2026 Jul 01; 9(7):e2622966. PMID: 42440317.

    Read at: PubMed

  • Published 6/23/2026

    Aaronson A, Ly MT, Tripodis Y, Altaras C, Lenio S, Farris CW, Nowinski CJ, O'Connor MK, Martin BM, Palmisano JN, Nosheny RL, Gifford KA, Steinberg EG, Turk KW, Budson AE, Stein TD, McKee AC, Mez J, Alosco ML. Subjective cognitive complaints and decline among aging individuals with prior repetitive head impact exposure. Alzheimers Dement (Amst). 2026; 18(2):e70407. PMID: 42358563.

    Read at: PubMed

  • Published 6/23/2026

    Tuz-Zahra F, Hallowell E, Tilton C, Alvarez VE, Aytan N, Hawkins S, Mez J, Alosco M, McKee AC, Tripodis Y, Stein TD, Cherry JD. CTE has multiple pathologic variants that might relate to different clinical symptom presentation. Acta Neuropathol. 2026 Jun 23; 151(1). PMID: 42334639.

    Read at: PubMed

View All 246 Publications:   View Full Profile in BUMC

Other Positions

  • Investigator
    Framingham Heart Study
  • Member, Evans Center for Interdisciplinary Biomedical Research
    Boston University

Websites

Education

  • University of Maryland School of Medicine, MD
  • Columbia University School of Public Health, MS
  • Cornell University, BS

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