Jeffrey R. Moore, PhD

Adjunct Associate Professor, Physiology & Biophysics

Jeffrey Moore
72 E. Concord St Instructional (L)


Our lab’s main interest is the study of molecular mechanics and cellular motility. We employ single molecule fluorescence techniques and laser trapping assays to study: the mechanism and regulation muscle contraction, cell motility, and the regulation of cell shape. Our lab’s investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin’s mechanical and enzymatic properties. We are also investigating the nature and regulation of cytoskeletal dynamics in differentiated vascular smooth muscle cells.


  • University of Vermont, PhD
  • University of Massachusetts Lowell, MS
  • University of Massachusetts Lowell, BS


  • Published on 12/5/2017

    Rynkiewicz MJ, Prum T, Hollenberg S, Kiani FA, Fagnant PM, Marston SB, Trybus KM, Fischer S, Moore JR, Lehman W. Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. Biophys J. 2017 Dec 05; 113(11):2444-2451. PMID: 29211998.

    Read at: PubMed
  • Published on 9/25/2017

    Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA. Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci U S A. 2017 Oct 10; 114(41):E8618-E8627. PMID: 28973866.

    Read at: PubMed
  • Published on 9/12/2017

    Egan PF, Moore JR, Ehrlicher AJ, Weitz DA, Schunn C, Cagan J, LeDuc P. Robust mechanobiological behavior emerges in heterogeneous myosin systems. Proc Natl Acad Sci U S A. 2017 Sep 26; 114(39):E8147-E8154. PMID: 28900011.

    Read at: PubMed
  • Published on 10/26/2016

    Sewanan LR, Moore JR, Lehman W, Campbell SG. Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling. Front Physiol. 2016; 7:473. PMID: 27833562.

    Read at: PubMed
  • Published on 4/20/2016

    Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, Bernstein SI. A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. J Mol Biol. 2016 Jun 05; 428(11):2446-61. PMID: 27107639.

    Read at: PubMed
  • Published on 2/15/2016

    Moore JR, Campbell SG, Lehman W. Structural determinants of muscle thin filament cooperativity. Arch Biochem Biophys. 2016 Mar 15; 594:8-17. PMID: 26891592.

    Read at: PubMed
  • Published on 1/14/2016

    Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan; 3(1):012002. PMID: 26798831.

    Read at: PubMed
  • Published on 6/30/2015

    Schmidt WM, Lehman W, Moore JR. Direct observation of tropomyosin binding to actin filaments. Cytoskeleton (Hoboken). 2015 Jun; 72(6):292-303. PMID: 26033920.

    Read at: PubMed
  • Published on 6/25/2015

    Karabina A, Kazmierczak K, Szczesna-Cordary D, Moore JR. Myosin regulatory light chain phosphorylation enhances cardiac ß-myosin in vitro motility under load. Arch Biochem Biophys. 2015 Aug 15; 580:14-21. PMID: 26116789.

    Read at: PubMed
  • Published on 4/17/2015

    Egan P, Moore J, Schunn C, Cagan J, LeDuc P. Emergent systems energy laws for predicting myosin ensemble processivity. PLoS Comput Biol. 2015 Apr; 11(4):e1004177. PMID: 25885169.

    Read at: PubMed

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